With the advancement of urbanization and motorization, urban traffic conditions increasingly affect both travel efficiency and system stability, yet existing studies based on high-frequency OD data mainly focus on single aspects such as congestion patterns or travel time variability, lacking a unified analytical framework that jointly captures time-varying travel impedance, reliability, and anomaly risks under comparable conditions, especially in cross-city contexts. This study constructs a standardized analytical framework with a novel integration based on a “city × weekday × 5 min interval” structure, using high-frequency navigation OD data from eight major cities in China over four consecutive weeks, totaling approximately 560,000 valid samples. Travel Time per Unit Distance (TTUD) is employed as the core metric, and a distance-stratified weighting approach is adopted to improve cross-city comparability. Reliability is characterized by variability, dispersion, and tail risk, and anomalous events are identified using a dynamic baseline. The results reveal clear intra-week temporal regularity and significant inter-city heterogeneity, with weekday evening peaks generally lasting longer than those on weekends, reflecting sustained commuting pressure and slower dissipation of travel demand. A total of 249 anomaly events are detected, with higher frequency and persistence on weekdays, highlighting the increased vulnerability of traffic systems during peak commuting periods and indicating that commuting periods are more prone to sustained deviations due to higher system load and demand instability. Overall, the proposed framework provides a unified and comparable basis for cross-city traffic performance evaluation and supports practical applications such as peak-period traffic management, congestion mitigation, and traffic risk monitoring.