Liquid Hydrogen (LH2) as an energy carrier for passenger aircraft has the potential to combine low climate impact and high lifecycle energy efficiency. Due to its significantly different physical properties compared to kerosene, the integration of LH2 fuel storage and distribution systems interacts with the general configuration of the aircraft. In order to assess promising configuration combinations quantitatively, an aircraft design and assessment framework is further developed. These additions are aimed at capturing the interdependencies originating from the fuel system integration choices at the aircraft level and quantifying the effect of trim drag. The framework is applied to a selection of LH2 mid-to-long-range aircraft designs. A comparison of the mass breakdown, aerodynamics breakdown and performance indicators such as specific energy consumption is carried out for the framework-generated aircraft models. A trim drag induced block fuel penalty is quantified for the aircraft selection as well as a mitigation strategy based on operational constraints.