Sherif Isaac

Dr. Sherif Isaac


Research Focus & Metrics

Academic Career Length

7Years (2020-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 April 2020 in Cureus
Verified
Journal Article
Open access
PDF file
HMHannah Meacher
Hannah Meacher
SHShady Hermena
Shady Hermena
SISherif Isaac
Sherif Isaac
Fractures of the radial head are common and account for one-third of elbow fractures. Management has evolved over the past few decades as have the techniques and implants used to treat them. However, no standardized treatment protocol exists because of the complexity with which these fractures may present. The complex, unstable, displaced, and multi-fragmentary fractures, also known as Mason type III fractures, remain one of the most challenging fractures to treat, especially if associated with other elbow injuries. There are various surgical treatment options available, including open reduction and internal fixation or radial head arthroplasty. The purpose of this study was to systematically review the current literature that assessed open reduction and internal fixation compare to radial head replacement to identify the best surgical treatment protocol for the management of Mason type III radial head fracture. All published clinical trials claiming to evaluate or cited elsewhere as being authoritative regarding the surgical treatment of radial head fractures were identified and evaluated. Studies in foreign languages (not in English) were excluded. Based on two randomized controlled trials, this review showed some weak evidence that arthroplasty results in better functional elbow outcomes and lower complication rates as compared to open reduction and internal fixation. There is a scarcity of good quality comparative studies and multicenter randomized controlled trials should be considered.

2 June 2025 in OBM Geriatrics
Verified
Journal Article
Open access
PDF file
AAAhmad Abdallatif
Ahmad Abdallatif
SISherif Isaac
Sherif Isaac
Meta-analysist to evaluate impact of Surgical Methods on Outcomes in periprosthetic supracondylar knee fracture management. This study examines the rate of functional outcomes and complications associated with two distinct surgical methods for the management of periprosthetic supracondylar knee fractures in patients treated with Low Contact Locking Plates (LCP) and Retrograde Intramedullary Nails (RIMN). With the growing prevalence of total knee replacements, the incidence of periprosthetic supracondylar knee fractures has concurrently increased. While the retrograde intramedullary nail has gained recognition as a viable alternative to the locking compression plate in addressing these fractures, ongoing investigations are required to ascertain the superiority of one technique over the other. An extensive literature review was conducted in accordance with PRISMA guidelines, utilizing electronic databases through a meticulously defined search strategy. All randomized controlled trials or comparative studies meeting the inclusion criteria were evaluated using Cochrane’s collaboration tool to assess methodological quality. Functional outcomes, union rates, and complication rates were employed as criteria for evaluation and comparison. A total of seven studies were incorporated into this metanalysis provide valuable insights into the efficacy and safety of the surgical approaches currently under review. The systematic review and meta-analysis indicate no significant differences in any of the outcome measures, although further extensive studies are warranted to draw more definitive conclusions.

26 June 2026 in Medicina
Verified
Journal Article
Open access
PDF file
TGTanwir Gul
Tanwir Gul
PDPrabhbir Singh Devgun
Prabhbir Singh Devgun
SFSohaib Feroz
Sohaib Feroz
ASAzka Syed
Azka Syed
SISherif Isaac
Sherif Isaac
MEMohammed Elmajee
Mohammed Elmajee
Background and Objectives: While multiple studies have compared mechanical alignment (MA) and kinematic alignment (KA) in total knee arthroplasty (TKA), the effect of alignment philosophy on the patellofemoral joint (PFJ) remains unclear. This systematic review evaluates PFJ-related outcomes following KA- versus MA-TKA indirectly through functional knee scores. Materials and Methods: A comprehensive search of Ovid MEDLINE, PubMed Central, and Embase was undertaken in October 2025 using search strategies developed by two independent librarians. Screening and data extraction were performed independently by two reviewers. All primary studies, including randomised and non-randomised studies, comparing KA- and MA-TKA that included functional Knee Society Score (KSS-F) or the Knee Injury and Osteoarthritis Outcome Score (KOOS) Sports subscale were included. Results: Of the 1570 identified studies, 13 met the inclusion criteria for the systematic review and meta-analysis. KA demonstrated a significant improvement in KSS-F at 1-year follow-up compared with MA (p < 0.05). At longer follow-up intervals, differences did not reach statistical significance (p = 0.07); however, outcomes consistently favoured KA, suggesting maintenance of the early functional advantage over time. Conclusions: KA-TKA is associated with superior PFJ-related functional outcomes at 1 year and shows a sustained trend towards improved performance in longer-term follow-up based on the surrogate scores. Further prospective studies incorporating PFJ-sensitive outcome measures are warranted to clarify long-term benefits.