Objective: This study aimed to produce and characterize nanofiber membranes (PLGA/HA@LMWH) containing Poly(lactic-co-glycolic acid)/Hyaluronic Acid (PLGA/HA) immobilized with low molecular weight heparin (LMWH), and to investigate their physical and chemical effects in preventing intraabdominal adhesions in a rat model using multidisciplinary methods. Materials and Methods: Forty female Wistar Albino rats were divided into four groups (n=10). Cecal abrasions were induced in three groups: treated with PLGA/HA membrane (NFM), PLGA/HA@LMWH membrane (NFM+H), and 0.9% NaCl (SS). The fourth group underwent laparotomy only. On day 21, rats were sacrificed and evaluated macroscopically, histopathologically, immunohistochemically, and biochemically. Results: Macroscopic adhesion, inflammation, fibrosis, neovascularization, collagen scores, and TGF-β1 expression were found to be high in the SS and NFM groups; while a significant decrease (p < 0.05–0.01) was detected in all of these values in the NFM+H group. NF-κB activation was significantly decreased in the NFM and especially the NFM+H groups compared to the SS group (p < 0.05). In addition, apoptosis was suppressed in the NFM+H group with increased Bcl-2 and decreased cleaved caspase-3. Conclusion: PLGA/HA@LMWH membrane reduced peritoneal adhesions by suppressing inflammation, fibrosis, neovascularization, and collagen deposition, lowering TGF-β1 expression and NF-κB and p-NF-κB levels, and suppressing apoptosis. However, large-scale studies are needed for clinical use.

The aim of this study was to objectively evaluate the presence of allergic reactions and pulmonary function in individuals working in small container-like

This study aimed to produce and characterize nanofiber membranes (PLGA/HA@LMWH) containing Poly(lactic-co-glycolic acid)/Hyaluronic Acid (PLGA/HA) immobilized with low-molecular-weight heparin (LMWH), and to investigate their physical and chemical effects in preventing intraabdominal adhesions in a rat model using multidisciplinary methods. Forty female Wistar Albino rats were divided into four groups (n = 10). Cecal abrasions were induced in three groups: treated with PLGA/HA membrane, PLGA/HA@LMWH membrane, and 0.9% NaCl (SS). The fourth group underwent laparotomy only. On day 21, rats were sacrificed and evaluated macroscopically, histopathologically, immunohistochemically, and biochemically. Macroscopic adhesion, inflammation, fibrosis, neovascularization, collagen scores, and TGF-β1 expression were found to be high in the SS and PLGA/HA groups, while a significant decrease (p < 0.05–0.01) was detected in all of these values in the PLGA/HA@LMWH group. NF-κB activation was significantly decreased in the PLGA/HA and especially the PLGA/HA@LMWH groups compared to the SS group (p < 0.05). In addition, apoptosis was suppressed in the PLGA/HA@LMWH group, with increased Bcl-2 and decreased cleaved caspase-3. The PLGA/HA@LMWH membrane reduced peritoneal adhesions by suppressing inflammation, fibrosis, neovascularization, and collagen deposition, lowering TGF-β1 expression and NF-κB and p-NF-κB levels, and suppressing apoptosis. However, large-scale studies are needed for clinical use.

Evaluation of the physician-patient relationship is very important in determining priorities in medical practice and medicine. For this purpose, in this study the psychiatrist’s communication with psychotic patients as a sensitive group was evaluated. A questionnaire was administered to 210 patients in a psychiatric clinic of Inonu University Hospital in Turkey to determine how the examination is performed in the facility for outpatients in the psychosis unit. According to the study conducted, it was observed that the evaluation score of the psychiatrist’s communication with psychotic patients increased positively with increasing consultation duration. Our work is particularly noteworthy because it deals with a sensitive area, such as a group of psychiatric patients. The scores were obtained based on data from the evaluation of the questionnaires, which showed that the communication between the psychiatrist and the psychotic patient was conducted in a sensitive and careful manner, and without ethical problems.