Modern aircraft fuel tank explosion protection relies critically on inerting efficiency. This study presents and investigates a novel scrubbing deoxygenation strategy utilizing mixed inert gas (MIG) generated by oxygen-consuming inerting systems for high-vapor-pressure RP5 aviation fuel. A high-fidelity computational fluid dynamics (CFD) numerical framework was established using the Eulerian–Eulerian two-fluid model coupled with Higbie’s penetration theory, with experimental validation ensuring computational accuracy (maximum errors for ullage oxygen concentration and dissolved oxygen in fuel controlled within 4.11% and 5.23%, respectively). The research systematically elucidates the influence mechanisms of bubble diameter, MIG temperature, and superficial gas velocity on mass transfer characteristics (oxygen mass transfer coefficient and volumetric mass transfer coefficient). Key findings reveal that reducing bubble diameter achieves localized polarization of mass transfer intensity in the central plume region through an “area-velocity” synergistic effect, with the oxygen volumetric mass transfer coefficient at 1.0 mm diameter increasing by 51.3% compared to 2.5 mm. The performance enhancement from superficial gas velocity primarily stems from the “area multiplication effect” triggered by surging gas holdup. Notably, MIG temperature exhibits a unique three-stage reversal characteristic of “kinetically dominated early stage, thermodynamically controlled late stage” on deoxygenation performance. These results provide critical physical foundations for the forward design of next-generation multifunctional onboard inerting systems.