BackgroundLiterature on the effects of second-generation H1-antihistamines on angiogenesis is limited.ObjectivesTo investigate the effects of cetirizine, desloratadine, and rupatadine (second-generation H1-antihistamines commonly used in dermatology clinics) on angiogenesis in an in vivo chick chorioallantoic membrane (CAM) model.MethodsThe study was approved by the local ethics committee on animal experimentation. Forty fertilized specific pathogen free eggs were incubated and kept under appropriate temperature and humidity control. Drug solutions were prepared in identical concentrations by dissolving powders in phosphate-buffered saline (PBS). On the third day of the incubation, a small window was opened on the CAM and 0.1 mL desloratadine (1.5 mu g/0.1 mL) in the first group, 0.1 mL cetirizine (1.5 mu g/0.1 mL) in the second group, 0.1 mL rupatadine in the third group (1.5 mu g/0.1 mL), and PBS (0.1 mL) in the fourth group were administered by injection. On the eighth day of incubation, the vascular structures of the CAMs were macroscopically examined and standard digital photographs were taken. The digital images were analyzed and data including mean vessel density, thickness, and number were compared between groups. p < 0.05 was considered statistically significant.ResultsVessel densities were similar in the desloratadine, cetirizine, and control groups, whereas they were significantly less in the rupatadine group (p = 0.01). Furthermore, the rupatadine group had significantly lower vessel thickness and number compared with the other groups (p < 0.05 for both).ConclusionsRupatadine showed anti-angiogenic effects in the chick CAM model, compared with desloratadine and cetirizine. The anti-angiogenic effect of rupatadine could be due to its platelet-activating factor (PAF) receptor inhibition. Thus, rupatadine could be a treatment agent in pathological processes in which angiogenesis is responsible. Further studies with larger series are needed to clarify this potential.

A 28-year-old woman presented with generalized hardening of the skin, joint immobility, shortness of breath and lower back pain since the age of 7 years.

Citation: Oraloğlu G, Duman N, Yaman B, Karaarslan I. Dermoscopic Features of Pilar Sheath Acanthoma. Dermatol Pract Concept. 2024;14(1):e2024070. DOI: https://doi.org/10.5826/dpc.1401a70 Accepted: August 21, 2023; Published: January 2024 Copyright: ©2024 Oraloğlu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (BY-NC-4.0), https://creativecommons.org/licenses/by-nc/4.0/, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original authors and source are credited. Funding: None. Competing interests: None. Authorship: All authors have contributed significantly to this publication. Corresponding author: Nilay Duman, Ege University, Faculty of Medicine, Department of Dermatology, Bornova, İzmir, Turkey. Tel: + 90 (232) 390 38 30 Phax: + 90 (232) 339 97 02 Email: nilyduman@gmail.com This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.