Introduction Ashwagandha, a traditional Indian plant, is gaining increasive attention from scientists worldwide due to its potential health benefits, especially in the context of its antibacterial and anticancer properties. Aim of the study The aim of this review was to discuss recent findings regarding the impact of Withania Somnifera on antibacterial effect and its potential applications in anticancer therapy. Materials and methods: The paper was created based on the Pubmed and Google Scholar database. The literature was reviewed using the keywards: ,,Ashwagandha”, ,,Withania Somnifera”, ,,antibacterial ”, ,,anticancer”, ,,side effects”, ,,breats cancer”. Results Studies have confirmed Withania Somnifera, exhibits significant anticacterial and anticancer effects. It inhibits the growth of both Gram-negative and Gram-positive bacteria. Futhermore, it demonstrates anticancer activity, especially in breast cancer, by stimulating apoptosis, induction of cytotoxic effects on cancerous cells and increasing cell sensitivity to radiation. Conclusion Despite promising results, futher research on the benefits of Ashwagandha, particulary in the long term, is essential. There is growing need of more research of the potencial benefits of Ashwagandha in the treatment of various disorders including cancer and bacterial infections and to develop more effective therapeutic strategies. The need for large randomized studies comparing long term clinical effectiveness is emphasized

Introduction The urachal anomaly is a developmental defect, a remnant of fetal life consisting of a patent connection between the dome of the urinary bladder and the umbilicus. It can take various forms. Most commonly it occurs in males, very rarely in adults. The main symptoms associated with this condition are: foul-smelling discharge from the umbilicus, abdominal pain, hematuria, or recurrent urinary tract infections. Imaging plays a crucial role in the diagnosis of the persistent urachus. Aim of the studyThe aim of the study is to sentize doctors’ attention that patent urachus is the rare but possible diagnosis of acute abdomen pain in adults population and bring the proceedings.Materials and methods: An analysis of papers avaliable on Pubmed and Google Scholar was performed. The following key words: urachal anomalies, adults, abdomen pain, urachal remnants, urachal carcinoma were used.Results:Lately, thanks to modern precise imaging diagnostics, more valuable studies have been conducted, allowing to characterize residual ureteral remnants, which are most often asymptomatic in population of adults. However the manifestation of symptoms is mostly associated with infection of the mentioned area or a tumor transformation. There are at least two case reports which report that infection of urachal remnants could manifestate after intensive physical activity. It is worth in-depth interviewing. Studies indicate the necessity of surgical removal of persistent urachal anomalies, as they carry the risk of rapid growth and unfavorable prognosis of cancerous spread.

Introduction In recent years, there has been tremendous development in medicine, including diabetology. A significant portion of these achievements pertains to pharmacological treatment. However, one should not overlook the advancement of devices necessary for monitoring glucose levels, such as glucometers or CGM and FGM systems. In this paper, I want to focus on how the use of glucose monitoring systems affects the course of diabetes. Aim of the study The aim of this study was to determine the impact of glucose monitoring systems (CGM and FGM) on parameters of metabolic control in diabetes. Materials and methods The article was created based on the PubMed and Scholar databases. The literature was analyzed using the following keywords: Continuous glucose monitor, CGM, flash glucose monitoring, FGM, type 1 diabetes, type 2 diabetes, diabetes mellitus, Metrics of Glycemic. Results Research has confirmed that the use of continuous glucose monitoring systems lowers HbA1c in patients with both type 1 and type 2 diabetes regardless of age and treatment modality. Furthermore, the use of CGM and FGM reduces the number of hypoglycemic episodes and increases time in range (TIR). Conclusions Thanks to the results obtained from numerous studies, it can be assumed that the use of continuous glucose monitoring systems is not only an adjunct to diabetes therapy but also an important component of it. With this technology combined with modern medications, we can achieve better glycemic control and, consequently, improve the quality of life of patients with diabetes.

Introduction: Asthma is a common inflammatory disease of airway affecting both adults and children. In a large number of cases asthma remains poorly controlled. There is a need to find an additional therapeutic demeanour alleviating symptoms and lowering the risk complications in a long-term. Recently, increasing number of studies has been examining dietary supplements in regards to their anti-inflammatory, immunomodulatory, anti-remodelling properties and their use in asthmatic patients. Aim of the Study: The aim of the study was to collect and analyse current literature regarding influence of different dietary supplements on the course of asthma in both adults and children. Methods and Materials: Extensive research was conducted using PubMed and Google Scholar, with the primary focus on literature from the past 5 years. Firstly, potential dietary supplements affecting course of asthma were collected. The names of the substances were juxtaposed with term “Asthma” to gather data regarding their effect on occurrence and control of asthma and potential mechanisms responsible for it. Additionally, references from selected articles were included in the analysis. Results: Dietary supplements show promising results in decreasing asthma symptoms and lowering inflammation of airway. However, our study revealed that in current state of knowledge there is a deficit of studies performed on humans, especially large-scale, prospective studies that assess the efficacy of different doses of dietary supplements. Thus, further research of dietary supplements in asthma is needed, especially large-scale randomised controlled trials.

Introduction Major depressive disorder (MDD) is one of the most common psychiatric disorders, with its prevalence on the rise. The use of mindfulness-based interventions (MBIs), primarily including mindfulness-based cognitive therapy (MBCT) and mindfulness-based stress reduction (MBSR), in MDD is scientifically justified. But will every population subgroup benefit from such an approach? Aim of the study The aim of our study is to analyze, based on the latest scientific findings, the effects of MBIs within specific subgroups of patients suffering from depression, including adolescents, elderly patients, cancer patients, individuals experiencing postnatal and perinatal depression, and patients with chronic pain. Additionally, we sought to summarize the current knowledge regarding the structural and functional effects of MBIs on the human brain. Materials and methods We conducted a comprehensive search of scientific databases including PubMed and Google Scholar to identify relevant articles focusing on MBIs and their effects on treating depression within various subgroups. Additionally, we performed a review of literature available on PubMed and Google Scholar to summarize the current knowledge regarding the impact of MBIs on the human brain. Conclusions Across various subgroups MBIs show promise in reducing depressive symptoms, indicating their potential as adjunctive treatments or preventive measures. While longer intervention durations are associated with larger effects, further research is needed to establish a solid evidence base, particularly in older populations and cancer patients with different cancer types.

In recent years, interest in probiotics in publications has been steadily increasing. This is associated with the discovery of the relationship between disruptions in the gut microbiome and dysfunction of the immune system, and consequently, the development of various diseases and allergies. The composition of the natural gut microbiota in newborns can undergo changes, and as a result, we can influence it both prenatally and postnatally. According to available research, factors influencing it include the timing and method of delivery, maternal antibiotic use during pregnancy and breastfeeding, as well as antibiotic use in newborns after birth, and the method of feeding the child. It is suspected that disturbances in the composition of gut microbiota from the earliest stages of life contribute to the development of disorders such as functional gastrointestinal disorders (diarrhea, constipation, irritable bowel syndrome), inflammatory bowel diseases, allergies, atopic dermatitis, neurodevelopmental disorders (autism spectrum disorders), and increased risk of obesity in later years of the child's life. When significant dysbiosis occurs, stimulating the growth of protective and nutritive autochthonous bacteria on the intestinal epithelium is difficult to achieve in any other way than using appropriately selected probiotic strains. However, it is important to remember to choose probiotics with a well-researched quantitative and qualitative composition, and to select them depending on the underlying disease, as well as the age and other conditions of the patient.