Crop rotation is a key practice for improving soil health, reducing chemical inputs, and ensuring sustainable agricultural productivity. This review synthesizes research from major agricultural regions worldwide, including North America, Europe, South America, South Asia, and Africa, with additional case studies from China to illustrate regional applications. This study presents a streamlined framework that integrates climate adaptability, crop combinations, yield-enhancing mechanisms, technological support, and regional optimization. By analyzing plant–soil–microbe interactions—including improvements in soil physical structure, nutrient cycling, microbial processes, and suppression of pests and diseases—we elucidate how rotation systems enhance the yield of subsequent crops. Precision agriculture technologies, such as variable-rate fertilization and remote sensing, have been shown to improve resource use efficiency and reduce labor input in certain cropping systems. Diversified crop rotations can substantially offset direct greenhouse gas emissions through enhanced soil carbon sequestration. The design of region-specific recommended rotation patterns should follow the principles of resource matching, stable yield and efficiency enhancement, and sustainability. This framework provides a practical reference for designing region-specific rotation systems and advancing sustainable agricultural development.