Health literacy has been reported to have effects on health behavior change and health-related outcomes, but few studies have explored the association between health literacy and frailty. The aim of our study is to investigate the relationships between health literacy and frailty among community-dwelling seniors. This cross-sectional study enrolled 603 community-dwelling older adults (307 women) in residential areas, with a mean age of 70.9 ± 5.82 years. Health literacy was assessed using the Mandarin version of the European Health Literacy Survey Questionnaire. Physical frailty was defined by Fried frailty phenotype. Logistic regression was carried out to determine potential risk factors of frailty. In the multivariate logistic regression model, physical activity (Odds Ratio [OR] 1.47, 95% Confidence Interval [CI] 1.06–2.03) and health literacy (sufficient vs. excellent: OR 2.51, 95% CI 1.32–4.77) were associated with prefrailty and frailty. In subgroup analysis, pre-frailty and frailty were also negatively associated with health literacy in individuals with ‘insufficiently active’ (inadequate vs. excellent: OR 5.44, 95% CI 1.6–18.45) and ‘sufficiently/highly active’ physical activity levels (sufficient vs. excellent: OR 2.41, 95% CI 1.07–5.42). Therefore, in these community-dwelling elderly adults, health literacy was associated with pre-frailty and frailty regardless of age, gender, socio-economic status, and education level.

Metabolic syndrome typically includes Type 2 diabetes associated with hyperglycemia, central obesity, dyslipidemia and hypertension. It is highly related to oxidative stress, formation of advanced glycated end products (AGEs) and key enzymes, such as carbohydrate digesting enzymes like pancreatic α-amylase and intestinal α-glucosidase, pancreatic lipase and angiotensin I-converting enzyme (ACE). This study used an in vitro approach to assess the potential of four extracts of Siegesbeckia orientalis linne on key enzymes relevant to metabolic syndrome. In this research, S. orientailis was firstly extracted by ethanol. The ethanol extract (SE) was then partitioned sequentially with hexane, ethyl acetate and methanol, and these extracts were named SE-Hex, SE-EA and SE-MeOH, respectively. The experimental results showed that SE-EA had the highest total phenolic content (TPC, 76.9 ± 1.8 mg/g) and the total flavonoids content (TFC, 5.3 ± 0.3 mg/g). This extract exhibited the most significant antioxidant activities, including DPPH radical-scavenging capacity (IC₅₀ = 161.8 ± 2.4 μg/mL), ABTS radical-scavenging capacity (IC₅₀ = 13.9 ± 1.5 μg/mL) and reducing power. For anti-glycation activities, SE-EA showed the best results in the inhibition of AGEs, as well as inhibitory activities against α-glucosidase (IC₅₀ = 362.3 ± 9.2 μg/mL) and α-amylase (IC₅₀ = 119.0 ± 17.7 μg/mL). For anti-obesity activities, SE-EA indicated the highest suppression effect on pancreatic lipase (IC₅₀ = 3.67 ± 0.52 mg/mL). Finally, for anti-hypertension activity, SE-EA also demonstrated the strongest inhibitory activity on ACE (IC₅₀ = 626.6 ± 15.0 μg/mL). Close relationships were observed among the parameters of TPC, antioxidant activities, inhibitory activities on α-amylase, α-glucosidase, lipase and ACE (R > 0.9). Moderate correlations were found among the parameters of TFC, antioxidant activities, and suppression of dicarbonyl compounds formation (R = 0.5–0.9). Taken together these in vitro studies reveal the therapeutic potential of SE-EA extract in the prevention and treatment of metabolic disorders.

Background/Objectives: Diet and sleep are both important modifiable factors in healthy aging, yet little is known about whether attention to healthy eating behaviors is associated with objectively measured sleep. This study examined the association between self-reported attention to fruit and vegetable intake and actigraphy-measured sleep efficiency among women aged 45 years and older. Methods: This cross-sectional study included 143 women aged 45 years and older recruited from community centers. Participants wore a wrist-worn actigraphy device continuously for 7 days and completed daily sleep logs. Attention to fruit and vegetable intake was assessed using a single-item, four-category self-report measure. Hierarchical multiple linear regression was used to examine its independent association with sleep efficiency after adjustment for sociodemographic, health-related, and psychological covariates. Results: The mean age of the participants was 56.34 ± 7.67 years, and the mean sleep efficiency was 82.69 ± 8.60%. In the fully adjusted model, participants who reported “often” paying attention to fruit and vegetable intake had significantly higher sleep efficiency than those who reported doing so “almost every day” (β = 0.24, p = 0.013). Older age was independently associated with lower sleep efficiency (β = −0.31, p = 0.001). Conclusions: In this exploratory cross-sectional study, a single-item measure of self-reported attentiveness to fruit and vegetable intake showed a category-specific association with actigraphy-measured sleep efficiency. Longitudinal studies using more detailed dietary and behavioral measures are needed to clarify the direction and meaning of this association.