Primary leiomyosarcoma of the bone is rare. Histologically, it resembles leiomyosarcoma of soft tissue. Given the rarity of this entity, its diagnosis should be made only after clinical studies and workup have excluded metastasis from other sites. Herein, we describe an additional case of primary bone leiomyosarcoma. We report a 32-year-old female patient, who presented with right knee pain and was found to have a right distal femur mass by imaging studies. Biopsy showed a neoplasm composed of fascicles of spindle cells, arranged in different patterns, with significant pleomorphism. The tumor cells were positive for smooth muscle actin, focally positive for desmin and H-caldesmon. No other masses in the body were detected by imaging studies. The diagnosis of leiomyosarcoma of the bone was rendered. Given the broad diagnostic differential of primary bone leiomyosarcoma, it is important to be aware of this rare bone tumor phenotype and of its histomorphologic and immunohistochemical features for an accurate diagnosis.

Primary laryngeal sarcomas are rare. Their nomenclature and classification are similar to soft tissue counterparts; however, there are notable differences between clinical presentation, behavior, treatment, and follow-up. There is sparse information regarding the clinical features, biologic behavior, and treatment modalities of laryngeal sarcomas. To increase our understanding about these tumors, we describe herein an additional series of four cases of different pathologic types of laryngeal sarcomas, including low-grade chondrosarcoma, leiomyosarcoma, well-differentiated liposarcoma, and undifferentiated pleomorphic sarcoma. Our main aim is to upsurge awareness about the morphologic variations of laryngeal sarcomas, to avoid potential pitfalls during histopathologic examination. It is essential to ensure that correct diagnosis, subclassification, and grading are achieved for proper guidance of treatment and clinical follow-up at multidisciplinary team meetings.

Artificial intelligence (AI) has pervaded many fields of medicine in the last few years on the wave of similar changes in other disciplines. Adoption of AI-driven technologies will progress in pathology in the years to come and will also transform our subspecialty of dermatopathology. From the adoption of AI in teaching to its use in clinical practice and in advancing our field through improved research capabilities, we expect a great deal of changes that will hopefully improve our assessment of tissue sections for several cutaneous pathologies. In this review, we offer an overview of where the use of these tools currently stands in dermatopathology and the potential directions that will transform the way we practice and do research. We cover AI’s role in diagnosing various skin conditions, such as melanocytic lesions and other cutaneous skin cancers, and inflammatory dermatoses. The review further covers AI’s contributions to workflow automation, like mitotic figure detection and counting, predictive analytics (e.g., melanoma prognosis), and educational tools (e.g., AI-driven simulators). It also addresses critical technical aspects, including data curation, algorithm development, and model validation. We aim to provide a comprehensive overview of how AI is transforming dermatopathology, from diagnosis and prognosis to education and clinical integration.

Background: Discoid lupus erythematosus (DLE) represents the most common variant of chronic cutaneous lupus erythematosus, a skin‐specific autoimmune disorder within the broader lupus erythematosus spectrum Clinically, DLE is characterized by erythematous, scaly plaques with areas of hyperpigmentation. These lesions predominantly occur on sun‐exposed areas, particularly the scalp and cheeks. Involvement of the genital skin is rare and poses a significant diagnostic challenge due to its clinical overlap with other inflammatory and infectious dermatoses. To date, only 14 cases involving genital skin have been documented in the literature, with most described in female patients and a particular tendency for the vulva to be affected. Case Presentation: We present the case of a 60‐year‐old female with a past medical history of systemic sclerosis and Raynaud's syndrome, who presented with well‐demarcated, erythematous, keratotic plaques with atrophy involving the inguinal creases and medial buttocks, associated with pruritus and recent onset of pain when sitting. The rash had been present for years. Clinical differential diagnoses included lichen sclerosus, lichen simplex chronicus, and psoriasis. Histopathologic examination revealed orthokeratosis and parakeratosis, epidermal hyperplasia, thickened basement membrane, dilated blood vessels, and perivascular inflammation. Plasmacytoid dendritic cells were present in the dermis and highlighted by CD123 immunohistochemical stain, supporting the diagnosis of DLE. Systemic evaluation was negative for systemic lupus erythematosus. The patient was started on treatment with topical corticosteroids. Conclusion: This case highlights the importance of including DLE in the differential diagnosis of chronic genital dermatoses and reinforces the value of histopathologic evaluation in such cases.