Aim: There is much evidence of an association between cancer and irisin that is an adipokine. This study researched on the relationship between prostate cancer (PCa) and irisin levels, and whether irisin can be used as a biomarker in the diagnosis of PCa. Materials and Methods: For the study groups, 50 primary PCa patients and 30 healthy male subjects were included in the PCa and healthy control groups, respectively. All volunteers in the healthy control group were screened for prostate cancer and other malignancies and chronic diseases. Volunteers who were determine to be completely healthy were included for healthy control group. In the serum samples of the subjects were measured free PSA, total PSA and irisin levels. Irisin levels were compared separately in terms of the Gleason scores and T stage. In addition to intergroup comparisons, the ROC curve for the irisin was plotted and power analysis was performed. Results: Free and total PSA levels in the PCa group were significantly higher compared to the healthy control group (p<0.05). In addition, irisin levels in the PCa group were significantly lower than in the healthy control group (p0.05). When the cut-off value was taken as 8.1, the sensitivity and specificity of irisin for PCa were as 80.5% and 90%, respectively. Conclusion: The results of this study indicate that the levels of irisin in the PCa group are considerably reduced and irisin may be used as a biomarker as well as free and total PSA.

Mini-PCNL is one of the most effective surgical methods in the treatment of kidney stones in pediatric patients. In this study, we aimed to compare PCNL in the supine–prone position in pediatric patients (especially operation time, postop complications, hospital stay and stone-free rates).We conducted our study in a randomized and prospective manner. Patients with lower pole stones larger than 1 cm, stones larger than 1.5 cm in the pelvis, upper pole, midpole or multiple locations, and patients who did not respond to ESWL or whose family that preferred mini-PCNL to be the primary treatment were included in the study. Patients with any previous kidney stone surgery, patients with coagulation disorders and patients with retrorenal colon were excluded from the study. Between 2021 and 2023, a total of 144 patients underwent PCNL. 68 of these patients had supine PCNL and 76 prone PCNL. Postoperative Clavien grade1 complication occurred in a total of 7 patients in the prone position; Clavien grade1 complication occurred in 1 patient in the supine position. The mean operation time for prone PCNL was 119.88 ± 28.32 min, and the mean operative time for supine PCNL was 98.12 ± 14.97 the mean hospitalization time in prone PCNL was 3.56 ± 1.12 days, and 3.00 ± 0.85 days in supine PCNL. In conclusion, supine PCNL is a safe and effective method in the treatment of pediatric kidney stones and postoperative complications were observed to be less; the operation time and hospital stay were shorter in supine PCNL.

Objective: The aim of our study is to investigate the effect of average and maximum ureteral wall thicknesses measured by computed tomography before the operation on ureteroscopy results.Materials and Methods: This prospective study was conducted with 103 patients who underwent ureteroscopy for ureteral stones between July and December 2021. The maximum ureteral wall thickness in the region of the ureteral stone and the average of the ureteral wall thicknesses measured from the 3-6-9-12 lines were calculated by non-contrast computed tomography. The operation time, residual stone, double j insertion status, and intraoperative complication status were examined according to the average ureteral wall thickness and maximum wall thickness.Results: Of the 103 patients included in the study, 77 were male, and 26 were female. The mean age of the patients was 43.83±15.11 years. The mean stone length was 10.76±3.84 mm. The average ureteral wall thickness was 3.81±1.24 mm, while the maximum ureteral wall thickness was 4.9±1.8 mm. It was found that as the maximum, and average ureteral wall thickness increased, the operation time, residual stone, double insertion rate, and post-ureteroscopic lesion scale grade increased (p<0.05).Conclusion: Maximum and average ureteral wall thicknesses are predictive factors for ureteroscopy results.