Clays, historically employed in traditional medical practices, have recently gained prominence within contemporary biomedical science, especially in the context of wound healing, due to advancements in nanotechnology and materials science. This review article investigates the physicochemical characteristics, biological processes, and therapeutic functions of clay materials—including bentonite, halloysite nanotubes, palygorskite, sepiolite, and synthetic clays like Laponite—in diverse wound-healing applications. These materials play a crucial role in the wound-healing process, including stopping bleeding, controlling inflammation, protecting against infection, and rebuilding tissue. They work through both passive and active methods. The layered or fibrous structure of these materials allows for efficient drug loading, controlled release, and mechanical support when used in hydrogels, films, and advanced drug delivery systems. Preclinical and initial clinical investigations have substantiated the biocompatibility, antimicrobial properties, and regenerative capabilities of these systems, although they have also revealed several challenges concerning toxicity, regulatory categorization, and standardization. Consequently, clay-based systems present a potentially valuable multifunctional platform for advancing next-generation wound-treatment therapies, necessitating additional translational and clinical research.