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Claudia I. Gamboa-Gómez
Unidad de Investigación Biomédica Instituto Mexicano del Seguro Social Durango Mexico

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Full article
Published: 24 February 2021 in Journal of Food Biochemistry
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The aim of this study was to evaluate the hypoglycemic and antioxidant potential of green tomato (Physalis ixocarpa Brot.) calyxes’ extracts. Three methods were used to obtain the extracts: maceration (M), ultrasound‐assisted (US), and infusion. Regarding in vitro hypoglycemic evaluation, glucose diffusion assay and enzymatic inhibitory action of α‐amylase and α‐glucosidase were performed. Whereas, for in vivo assessment an oral starch tolerance test (OSTT) was tested with aqueous extracts [infusion (40 mg/kg b. wt.), maceration (M) water (98 mg/kg b. wt.), and US water (82.24 mg/kg b. wt.)] on male Wistar rats. Additionally, in vitro antioxidant activity of P. ixocarpa calyxes’ was evaluated through inhibition of scavenging radical assay and lipid peroxidation. Extracts decreased the glucose diffusion in a range of 18%–56% compared with the negative control. Additionally, extracts inhibited α‐amylase (above 80%) and α‐glucosidase enzymes (above 90%). All groups treated with P. ixocarpa calyxes’ significantly reduced the glucose levels at 120 min (infusion = 13.3%, M Water = 12.7%, and US Water = 19.4%) in comparison with the negative control, and similar levels to acarbose at 120 min (13.1%). Finally, extracts showed IC50 values in a range of 2.5–6.6 µg/µl for radical scavenging, and 118–199 µg/µl for lipid oxidation. Our results show that P. ixocarpa calyxes’ extracts induce hypoglycemia and antioxidant effects in vitro and in vivo. Practical applications The green tomato is usually consumed in Mexico, the United States, and Central America. This fruit grows inside a calyx, which is considered an agro‐food waste. However, some regions of Latin America have a traditional medicine purpose for diabetes affections. To the best of our knowledge, there are no published data that supports its hypoglycemic action. The information provided will be useful to nutraceutical applications that allow value‐added products and sustainable green tomato production.

ACS Style

Fernando Guerrero‐Romero; Luis E. Simental‐Mendía; María Inés Guerra Rosas; Víctor Iván Sayago‐Monreal; Juliana Morales Castro; Claudia I. Gamboa‐Gómez. Hypoglycemic and antioxidant effects of green tomato ( Physalis ixocarpa Brot.) calyxes’ extracts. Journal of Food Biochemistry 2021, 45, e13678 .

AMA Style

Fernando Guerrero‐Romero, Luis E. Simental‐Mendía, María Inés Guerra Rosas, Víctor Iván Sayago‐Monreal, Juliana Morales Castro, Claudia I. Gamboa‐Gómez. Hypoglycemic and antioxidant effects of green tomato ( Physalis ixocarpa Brot.) calyxes’ extracts. Journal of Food Biochemistry. 2021; 45 (4):e13678.

Chicago/Turabian Style

Fernando Guerrero‐Romero; Luis E. Simental‐Mendía; María Inés Guerra Rosas; Víctor Iván Sayago‐Monreal; Juliana Morales Castro; Claudia I. Gamboa‐Gómez. 2021. "Hypoglycemic and antioxidant effects of green tomato ( Physalis ixocarpa Brot.) calyxes’ extracts." Journal of Food Biochemistry 45, no. 4: e13678.

Research article
Published: 08 February 2021 in Endocrine Research
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Background. Given the numerous gaps in our knowledge about the biological interactions of lipoprotein(a) [Lp(a)], we determined whether Lp(a) was associated with hyperinsulinemia in healthy normal-weight, prepubertal children. Methods. A total of 131 healthy normal-weight Mexican children aged 6 to 9 years at Tanner stage 1 who were born appropriate for gestational age were enrolled in a case–control study. Children with hyperinsulinemia were allocated into the case group (n = 32), and children with normal insulin levels were allocated into the control group (n = 99). Birth weight, age, and body mass index were matching criteria. Multivariate logistic regression analysis was used to compute the odds ratio (OR) between Lp(a) and both hyperinsulinemia and insulin resistance. Furthermore, a multivariate linear regression analysis was performed to evaluate the association between Lp(a) and both insulin levels and HOMA-IR. Both models were adjusted by sex, age, birth weight, and body mass index. Results. The median (25–75 percentile) serum levels of Lp(a) [20.0 (13.7–29.6) versus 14.6 (10.6–26.7) mg/dL, p = .003] and insulin [24.5 (6.0–30) versus 7.9 (4.3–9.0) µU/L, p < .0005] were higher in the case group than in the control group. The logistic regression analysis showed that Lp(a) was associated with hyperinsulinemia (OR 5.86; 95%CI 2.5–13.6, p < .0005) and insulin resistance (OR 2.01; 95%CI 1.1–9.9, p = .004). In addition, the linear regression analysis showed a significant association between serum Lp(a) and insulin levels (β 11.1; 95%CI 1.8–10.9, p < .0001) and the HOMA-IR index (β 2.606; 95%CI 2.3–2.9, p < .0005). Conclusion. Lp(a) was associated with hyperinsulinemia and insulin resistance in healthy normal-weight, prepubertal children.

ACS Style

Martha Rodríguez-Moran; Claudia I. Gamboa-Gómez; Lucia Preza-Rodríguez; Fernando Guerrero-Romero. Lipoprotein(a) and Hyperinsulinemia in Healthy Normal-weight, Prepubertal Mexican Children. Endocrine Research 2021, 1 -5.

AMA Style

Martha Rodríguez-Moran, Claudia I. Gamboa-Gómez, Lucia Preza-Rodríguez, Fernando Guerrero-Romero. Lipoprotein(a) and Hyperinsulinemia in Healthy Normal-weight, Prepubertal Mexican Children. Endocrine Research. 2021; ():1-5.

Chicago/Turabian Style

Martha Rodríguez-Moran; Claudia I. Gamboa-Gómez; Lucia Preza-Rodríguez; Fernando Guerrero-Romero. 2021. "Lipoprotein(a) and Hyperinsulinemia in Healthy Normal-weight, Prepubertal Mexican Children." Endocrine Research , no. : 1-5.

Full article
Published: 07 October 2020 in Journal of Food Biochemistry
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The aim of this study was to evaluate the hypoglycemic and antioxidant potential of konjac in vitro and in vivo. Glucose diffusion and enzymatic starch digestion of konjac were assayed using α‐amylase and α‐glucosidase. Oral glucose tolerance test (OGTT) and oral starch tolerance test (OSTT) were performed at dose of 102 mg/Kg of body weight (equivalent to 1 g/meal in humans). Additionally, the antioxidant activity of konjac was evaluated through inhibition of lipid peroxidation. The konjac decreased glucose diffusion by 36% and 19% compared with the negative and positive controls, respectively. Additionally, konjac inhibited α‐amylase and α‐glucosidase activities by 14% and 90%, respectively. After OSTT, group treated with konjac showed significant lower glucose levels compared with control group (p = .03). Finally, konjac reduced lipid peroxidation in human plasma (93%) compared with the negative control. Our results suggest that konjac exhibits hypoglycemic and antioxidant activities in vitro and in vivo. Practical applications Because the use of herbal products have emerged as an attractive therapeutic option for chronic diseases, konjac administration may be an adjuvant for the treatment of type 2 diabetes.

ACS Style

Claudia I. Gamboa‐Gómez; Fernando Guerrero‐Romero; Miguel A. Sánchez‐Meraz; Luis E. Simental‐Mendía. Hypoglycemic and antioxidant properties of konjac ( Amorphophallus konjac ) in vitro and in vivo. Journal of Food Biochemistry 2020, 44, e13503 .

AMA Style

Claudia I. Gamboa‐Gómez, Fernando Guerrero‐Romero, Miguel A. Sánchez‐Meraz, Luis E. Simental‐Mendía. Hypoglycemic and antioxidant properties of konjac ( Amorphophallus konjac ) in vitro and in vivo. Journal of Food Biochemistry. 2020; 44 (12):e13503.

Chicago/Turabian Style

Claudia I. Gamboa‐Gómez; Fernando Guerrero‐Romero; Miguel A. Sánchez‐Meraz; Luis E. Simental‐Mendía. 2020. "Hypoglycemic and antioxidant properties of konjac ( Amorphophallus konjac ) in vitro and in vivo." Journal of Food Biochemistry 44, no. 12: e13503.

Full article
Published: 21 July 2020 in Journal of Food Biochemistry
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We evaluate the hypoglycemic and antioxidant effects of five commercial turmeric (Curcuma longa ) supplements: (1) bulk samples, (2) turmeric root from India, (3) curcuma turmeric Pronat®, (4) turmeric & black pepper Swanson®, and (5) C3 complex® turmeric curcumin. Glucose diffusion and enzymatic starch digestion assays, using α‐amylase and α‐glucosidase, were performed. The antioxidant activity of turmeric supplements was measured through lipid peroxidation inhibition and the scavenging radical assay. A starch dose of 102 mg/Kg of body weight (equivalent to 1 g/day in humans) was used to perform the oral starch tolerance test (OSTT) in Wistar male rats. All turmeric supplements decreased glucose diffusion and α‐glucosidase enzyme activity, and inhibited lipid peroxidation. The rats that received bulk samples and CT showed significantly lower glucose levels than rats receiving acarbose and those of negative control group. Our results show that biological activities of turmeric supplements vary according to the commercial presentation. Practical applications The study results suggest that the hypoglycemic and antioxidant effects of five commercial turmeric supplements vary among them. The information provided would be useful to physicians and individuals using these supplements.

ACS Style

Fernando Guerrero‐Romero; Luis E. Simental‐Mendía; Gerardo Martínez‐Aguilar; Miguel A. Sánchez‐Meraz; Claudia I. Gamboa‐Gómez. Hypoglycemic and antioxidant effects of five commercial turmeric ( Curcuma longa ) supplements. Journal of Food Biochemistry 2020, 44, 1 .

AMA Style

Fernando Guerrero‐Romero, Luis E. Simental‐Mendía, Gerardo Martínez‐Aguilar, Miguel A. Sánchez‐Meraz, Claudia I. Gamboa‐Gómez. Hypoglycemic and antioxidant effects of five commercial turmeric ( Curcuma longa ) supplements. Journal of Food Biochemistry. 2020; 44 (9):1.

Chicago/Turabian Style

Fernando Guerrero‐Romero; Luis E. Simental‐Mendía; Gerardo Martínez‐Aguilar; Miguel A. Sánchez‐Meraz; Claudia I. Gamboa‐Gómez. 2020. "Hypoglycemic and antioxidant effects of five commercial turmeric ( Curcuma longa ) supplements." Journal of Food Biochemistry 44, no. 9: 1.

Original article
Published: 22 May 2019 in Journal of Food Processing and Preservation
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The effect of dehydrated apple‐based snack supplemented with Agave fructans on short‐chain fatty acids (SCFA) production in mice was evaluated. Animals were randomly divided into three groups (n = 8): Control group (CG), oligofructose (OG), and Agave fructans (AG). After 24 days of treatment (stage 1), AG and OG showed elevated levels of acetate (10 µmol/g for both treatments), propionate (2.4 µmol/g for both treatments), and butyrate (1.5 and 3.2 µmol/g for OG and AG, respectively) compared with the CG. After 42 days of treatment (stage 2), AG had higher concentrations of acetate (20.8 µmol/g), propionate (2.1 µmol/g), and butyrate (5.5 µmol/g); whereas, OG only exhibited higher levels of acetate (16.8 µmol/g) and butyrate (5.6 µmol/g) in comparison with the controls. Dehydrated apple‐based snack supplemented with Agave fructans exhibits a prebiotic effect increasing SCFA production in mice. Practical applications Dehydrated fruit‐based snacks are generally perceived by consumers as healthy products with acceptable sensory attributes. They have a prolonged shelf life and may be consumed directly or cut into small parts for use in confectionery and bakery. In addition, the products derived from fruits plus prebiotics can enhance the beneficial effect on health and increase their consumption. This study opens up some commercial potential and technical challenges of using prebiotic‐based supplements.

ACS Style

Silvia Marina González‐Herrera; Nuria E. Rocha‐Guzmán; Luis E. Simental‐Mendía; Raúl Rodríguez‐Herrera; Cristobal N. Aguilar; Olga Miriam Rutiaga Quiñones; Mercedes G. López; Claudia I. Gamboa‐Gómez. Dehydrated apple‐based snack supplemented with Agave fructans exerts prebiotic effect regulating the production of short‐chain fatty acid in mice. Journal of Food Processing and Preservation 2019, 43, e14026 .

AMA Style

Silvia Marina González‐Herrera, Nuria E. Rocha‐Guzmán, Luis E. Simental‐Mendía, Raúl Rodríguez‐Herrera, Cristobal N. Aguilar, Olga Miriam Rutiaga Quiñones, Mercedes G. López, Claudia I. Gamboa‐Gómez. Dehydrated apple‐based snack supplemented with Agave fructans exerts prebiotic effect regulating the production of short‐chain fatty acid in mice. Journal of Food Processing and Preservation. 2019; 43 (8):e14026.

Chicago/Turabian Style

Silvia Marina González‐Herrera; Nuria E. Rocha‐Guzmán; Luis E. Simental‐Mendía; Raúl Rodríguez‐Herrera; Cristobal N. Aguilar; Olga Miriam Rutiaga Quiñones; Mercedes G. López; Claudia I. Gamboa‐Gómez. 2019. "Dehydrated apple‐based snack supplemented with Agave fructans exerts prebiotic effect regulating the production of short‐chain fatty acid in mice." Journal of Food Processing and Preservation 43, no. 8: e14026.

Article
Published: 23 February 2019 in Food Science and Biotechnology
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The aim of this study was to evaluate the effect of agave fructans on short chain fatty acid (SCFA) production in mice (C57BL/6). Animals were randomly divided into three groups (n = 8): control group (CG), fructans from Agave tequilana group (FG) (55 g per day/kg of body weight), and oligrofructose group (OG) (55 g per day/kg of body weight). Treatments were administered oral via for 6 weeks. After 24 days of treatment (phase 1), both treated groups exhibited elevated levels of acetic (12%) and propionic (FG 66% and OG 38%) acids in comparison with the CG. After 42 days of treatment (phase 2), FG had higher concentrations of acetic (33%) and propionic (73%) acids than the CG; while OG exhibited higher levels of butyric (12%) and propionic (35%) acids compared with the CG. Fructans from Agave tequilana improve the production of SCFA in mice, suggesting a prebiotic activity.

ACS Style

Silvia M. González-Herrera; Luis E. Simental-Mendía; Mercedes G. López; Nuria E. Rocha-Guzmán; Olga M. Rutiaga-Quiñones; Raúl Rodríguez-Herrera; Claudia I. Gamboa-Gómez. Effect of agave fructans on the production of short chain fatty acid in mice. Food Science and Biotechnology 2019, 28, 1493 -1498.

AMA Style

Silvia M. González-Herrera, Luis E. Simental-Mendía, Mercedes G. López, Nuria E. Rocha-Guzmán, Olga M. Rutiaga-Quiñones, Raúl Rodríguez-Herrera, Claudia I. Gamboa-Gómez. Effect of agave fructans on the production of short chain fatty acid in mice. Food Science and Biotechnology. 2019; 28 (5):1493-1498.

Chicago/Turabian Style

Silvia M. González-Herrera; Luis E. Simental-Mendía; Mercedes G. López; Nuria E. Rocha-Guzmán; Olga M. Rutiaga-Quiñones; Raúl Rodríguez-Herrera; Claudia I. Gamboa-Gómez. 2019. "Effect of agave fructans on the production of short chain fatty acid in mice." Food Science and Biotechnology 28, no. 5: 1493-1498.

Journal article
Published: 01 November 2018 in Beverages
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The effect of high-intensity pulsed electric fields (HiPEF) has been reported on the microbial resistance of fruit juices and beverages. However, the influence of HiPEF on bioactive compounds in herbal infusions is still limited. The objective of the present work was to evaluate chemical stability of polyphenols of infusions from Buddleja scordioides or Salvilla under thermal processing (concentrates) followed by HiPEF treatments. Buddleja infusions were prepared at 1% w/v of salvilla, heated, filtered and concentrated in a thin falling film evaporator. Three different HiPEF treatments were applied to Buddleja scordioides concentrated beverages. The percentage of pulse rate was 25 and 90%; output temperature, 18.3 ± 1 °C; and the frequency range, 100, 300 and 400 Hz. The feed flow was 0.5 L/h. DPPH radical scavenging assay, inhibition of Nitric Oxide activity and analysis of phenolic acids and flavonoids by UPLC-ESI-MS/MS were determined. ANOVA one-way analysis and Tukey test (p < 0.05) were used to analyze results. Concentration process increases the amount of flavonols; however, the use of HiPEF produces a minor reduction on antioxidant capacity. The use of HiPEF at 1000 kJ/kg and 1100 kJ/kg displays a similar profile on phenolic acids between HiPEF-treated beverages and concentrates, showing that the use of HiPEF may be a promissory technology in the processing practices of herbal infusions.

ACS Style

Jesús Omar Díaz-Rivas; José Alberto Gallegos-Infante; Aurora Valdez-Fragoso; Nuria Elizabeth Rocha-Guzmán; Rubén Francisco González-Laredo; Alfredo Rodríguez-Ramírez; Claudia Ivette Gamboa-Gómez; Martha Rocío Moreno-Jiménez. Comparative Study of Phenolic Profile and Content in Infusions and Concentrated Infusions of Buddleja Scordioides Treated by High-Intensity Pulsed Electric Fields (HiPEF). Beverages 2018, 4, 81 .

AMA Style

Jesús Omar Díaz-Rivas, José Alberto Gallegos-Infante, Aurora Valdez-Fragoso, Nuria Elizabeth Rocha-Guzmán, Rubén Francisco González-Laredo, Alfredo Rodríguez-Ramírez, Claudia Ivette Gamboa-Gómez, Martha Rocío Moreno-Jiménez. Comparative Study of Phenolic Profile and Content in Infusions and Concentrated Infusions of Buddleja Scordioides Treated by High-Intensity Pulsed Electric Fields (HiPEF). Beverages. 2018; 4 (4):81.

Chicago/Turabian Style

Jesús Omar Díaz-Rivas; José Alberto Gallegos-Infante; Aurora Valdez-Fragoso; Nuria Elizabeth Rocha-Guzmán; Rubén Francisco González-Laredo; Alfredo Rodríguez-Ramírez; Claudia Ivette Gamboa-Gómez; Martha Rocío Moreno-Jiménez. 2018. "Comparative Study of Phenolic Profile and Content in Infusions and Concentrated Infusions of Buddleja Scordioides Treated by High-Intensity Pulsed Electric Fields (HiPEF)." Beverages 4, no. 4: 81.

Original research
Published: 04 September 2018 in Medicinal Chemistry Research
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The aim of the study was to evaluate the effect of Buddleja scordioides Kunth leaves infusion on lipid peroxidation in mice with ultraviolet (UV) light-induced oxidative stress. CD-1 mice were allocated into treatment and control groups (n = 8). Mice in the intervention group were treated with B. scordioides leaves infusion (500 µL equivalent to 0.6534 mg of lyophilized leave infusion/kg of body weight) while the controls received distilled water by gavage administration during 9 days. Both groups were UV irradiated (2.59320175 mW/cm2) 4 consecutive days: 3 h per day with rest periods of 4 min every hour. B. scordioides leaves infusion had high concentrations of hydroxybenzoic acids, flavonols, hydroxycinnamic acids, and flavone compounds. Mice previously treated with B. scordioides leaves infusion exhibited a significant reduction on malondialdehyde (MDA) concentrations in the liver (77%) but not in kidney and plasma in comparison with the control group. B. scordioides leaves infusion shows hepatoprotective activity via free radical scavenging in mice with UV light-induced oxidative stress.

ACS Style

Nuria E. Rocha-Guzmán; Luis E. Simental-Mendía; Laura J. Barragán-Zúñiga; Julio C. Ramírez-España; J. Alberto Gallegos-Infante; Claudia I. Lujan-Mendoza; Claudia I. Gamboa-Gómez. Effect of Buddleja scordioides K. leaves infusion on lipid peroxidation in mice with ultraviolet light-induced oxidative stress. Medicinal Chemistry Research 2018, 27, 2379 -2385.

AMA Style

Nuria E. Rocha-Guzmán, Luis E. Simental-Mendía, Laura J. Barragán-Zúñiga, Julio C. Ramírez-España, J. Alberto Gallegos-Infante, Claudia I. Lujan-Mendoza, Claudia I. Gamboa-Gómez. Effect of Buddleja scordioides K. leaves infusion on lipid peroxidation in mice with ultraviolet light-induced oxidative stress. Medicinal Chemistry Research. 2018; 27 (10):2379-2385.

Chicago/Turabian Style

Nuria E. Rocha-Guzmán; Luis E. Simental-Mendía; Laura J. Barragán-Zúñiga; Julio C. Ramírez-España; J. Alberto Gallegos-Infante; Claudia I. Lujan-Mendoza; Claudia I. Gamboa-Gómez. 2018. "Effect of Buddleja scordioides K. leaves infusion on lipid peroxidation in mice with ultraviolet light-induced oxidative stress." Medicinal Chemistry Research 27, no. 10: 2379-2385.