This study investigates the seismic response of reinforced concrete buildings designed according to the current Italian building code. Number of stories, site hazard, presence and distribution of masonry infill panels, and type of lateral resisting system are the key investigated parameters. The main issues related to design and modeling are discussed. Two Limit States are considered, namely Global Collapse and Usability-Preventing Damage. The main aim of the study is a comparison between the seismic response of the buildings, investigated through nonlinear static and dynamic analyses. Irregularity in the distribution of infill panels and site hazard emerge as the most influential parameters.