To compare Human Papillomavirus (HPV) detection in first-void urine (FVU) and cervicovaginal samples and to analyze factors associated with cervicovaginal HPV infection among women in Tunja, Colombia. A cross-sectional study was conducted among 161 women aged 20–65 years residing in Tunja, Colombia. Samples and data were collected between September and November 2022 in a clinical laboratory. Cervicovaginal and FVU samples were obtained for HPV genotyping using the INNO-LiPA HPV Genotyping Extra II kit. Concordance, sensitivity, specificity, and associations with sociodemographic and gynecological variables were evaluated. Crude and adjusted odds ratios (OR) were estimated using logistic regression. HPV prevalence was 29.19% in cervicovaginal samples and 32.91% in urine samples. Genotypes 52 and 68 were the most frequent in both sample types. Concordance between tests was weak (kappa = 0.39). Sensitivity and specificity of urine-based detection were 61.70% and 78.94%, respectively. In the multivariable model, only pregnancy history remained independently associated with cervicovaginal HPV infection. HPV infection prevalence was moderate, with high-risk genotypes detected in both sample types. The history of pregnancy was the only independent factor associated with cervicovaginal HPV infection. HPV detection in urine showed limited diagnostic performance, highlighting the need to optimize urine screening strategies.

Introducción: La tuberculosis es una enfermedad crónica causada por el complejo Mycobacterium tuberculosis (M. tuberculosis), considerada una de las diez principales causas de muerte en el mundo. A pesar de los avances en diagnóstico, sigue representando un desafío, debido a la necesidad de una búsqueda activa de sintomáticos respiratorios. Objetivo: Determinar la prevalencia, factores asociados y sensibilidad a medicamentos antituberculosos en especies del complejo M. tuberculosis en pacientes sintomáticos respiratorios, durante el primer semestre de 2024. Metodología: Se realizó un estudio retrospectivo, analítico y transversal con una base de datos codificada de muestras clínicas procesadas en un laboratorio de Tunja. Se aplicó un muestreo por conveniencia, incluyendo muestras pulmonares y extrapulmonares remitidas desde distintos municipios de Boyacá. Se realizó un análisis bivariado mediante prueba Chi2 y modelo multivariado, con un intervalo de confianza (IC) del 95%. Resultados: El 64,1 % (n = 407) de los pacientes fueron hombres, con una edad promedio de 55 ± 21,6 años. La prevalencia del complejo M. tuberculosis fue del 6,3 % (n = 40) con un IC 95 % (4,41–8,19). No se evidenció resistencia a isoniazida, rifampicina o quinolonas. El riesgo de infección fue mayor en hombres (RP = 2,2; IC 95 %: 1,05–4,78) y en el grupo de 18–26 años (RP = 6,5 frente a ≥60 años; IC 95 %: 3,55–12,03). Conclusión: Se identificó una prevalencia de 6.3% para el complejo de M. tuberculosis sin mecanismos de resistencia dentro del periodo analizado.

The present study evaluated the association between morning serum cortisol levels and burnout syndrome among healthcare workers in the department of Boyacá, Colombia. An observational, analytical, cross-sectional, and quantitative study was conducted on 69 employees. Total serum cortisol was measured via chemiluminescence in fasting morning samples (reference: 110–692 nmol/L). Burnout was assessed using the Maslach Burnout Inventory–General Survey (MBI-GS). A total of 96.6% of participants fell within the normal range for serum cortisol. MBI-GS dimensions reported mean scores of: exhaustion 1.54 ± 1.17, cynicism 0.93 ± 0.89, and professional efficacy 5.60 ± 0.60. High exhaustion prevalence was 16.9%, high cynicism 6.8%, and low efficacy 3.4%. Profile classification showed 67.8% “engaged,” 13.6% “overextended/worn-out,” and 5.1% with “burnout.” No significant association was found between cortisol and burnout dimensions: exhaustion (r = 0.069, p = 0.605), cynicism (r = −0.135, p = 0.309), and professional efficacy (r = 0.044, p = 0.742). Mean cortisol comparisons between high and low dimension groups showed no statistically significant differences (p > 0.05). The study documented a low prevalence of established burnout and an absence of significant association between morning serum cortisol and MBI-GS dimensions, suggesting a relatively healthy work environment; however, the prevalence of high emotional exhaustion warrants preventive interventions. Multilevel organizational strategies like workload management, job stability, role clarity, and psychosocial support are recommended for worker mental health protection.