Although machine learning (ML) has shown promise across disciplines, out-of-sample generalizability is concerning. This is currently addressed by sharing multi-site data, but such centralization is challenging/infeasible to scale due to various limitations. Federated ML (FL) provides an alternative paradigm for accurate and generalizable ML, by only sharing numerical model updates. Here we present the largest FL study to-date, involving data from 71 sites across 6 continents, to generate an automatic tumor boundary detector for the rare disease of glioblastoma, reporting the largest such dataset in the literature (n = 6, 314). We demonstrate a 33% delineation improvement for the surgically targetable tumor, and 23% for the complete tumor extent, over a publicly trained model. We anticipate our study to: 1) enable more healthcare studies informed by large diverse data, ensuring meaningful results for rare diseases and underrepresented populations, 2) facilitate further analyses for glioblastoma by releasing our consensus model, and 3) demonstrate the FL effectiveness at such scale and task-complexity as a paradigm shift for multi-site collaborations, alleviating the need for data-sharing.

A steady rise has been observed in the percentage of elderly people who want and are still able to contribute to society. Therefore, early retirement or exit from the labour market, due to health-related issues, poses a significant problem. Nowadays, thanks to technological advances and various data from different populations, the risk factors investigation and health issues screening are moving towards automation. In the context of this work, a worker-centric, IoT enabled unobtrusive users health, well-being and functional ability monitoring framework, empowered with AI tools, is proposed. Diabetes is a high-prevalence chronic condition with harmful consequences for the quality of life and high mortality rate for people worldwide, in both developed and developing countries. Hence, its severe impact on humans' life, e.g., personal, social, working, can be considerably reduced if early detection is possible, but most research works in this field fail to provide a more personalized approach both in the modeling and prediction process. In this direction, our designed system concerns diabetes risk prediction in which specific components of the Knowledge Discovery in Database (KDD) process are applied, evaluated and incorporated. Specifically, dataset creation, features selection and classification, using different Supervised Machine Learning (ML) models are considered. The ensemble WeightedVotingLRRFs ML model is proposed to improve the prediction of diabetes, scoring an Area Under the ROC Curve (AUC) of 0.884. Concerning the weighted voting, the optimal weights are estimated by their corresponding Sensitivity and AUC of the ML model based on a bi-objective genetic algorithm. Also, a comparative study is presented among the Finnish Diabetes Risk Score (FINDRISC) and Leicester risk score systems and several ML models, using inductive and transductive learning. The experiments were conducted using data extracted from the English Longitudinal Study of Ageing (ELSA) database.

Conventional biomechanical modelling approaches involve the solution of large systems of equations that encode the complex mathematical representation of human motion and skeletal structure. To improve stability and computational speed, being a common bottleneck in current approaches, we apply machine learning to train surrogate models and to predict in near real-time, previously calculated medial and lateral knee contact forces (KCFs) of 54 young and elderly participants during treadmill walking in a speed range of 3 to 7 km/h. Predictions are obtained by fusing optical motion capture and musculoskeletal modeling-derived kinematic and force variables, into regression models using artificial neural networks (ANNs) and support vector regression (SVR). Training schemes included either data from all subjects (LeaveTrialsOut) or only from a portion of them (LeaveSubjectsOut), in combination with inclusion of ground reaction forces (GRFs) in the dataset or not. Results identify ANNs as the best-performing predictor of KCFs, both in terms of Pearson R (0.89–0.98 for LeaveTrialsOut and 0.45–0.85 for LeaveSubjectsOut) and percentage normalized root mean square error (0.67–2.35 for LeaveTrialsOut and 1.6–5.39 for LeaveSubjectsOut). When GRFs were omitted from the dataset, no substantial decrease in prediction power of both models was observed. Our findings showcase the strength of ANNs to predict simultaneously multi-component KCF during walking at different speeds—even in the absence of GRFs—particularly applicable in real-time applications that make use of knee loading conditions to guide and treat patients.

This paper proposes an innovative gait identification and authentication method based on the use of novel 2-D and 3-D features. Depth-related data are assigned to the binary image silhouette sequences using two new transforms: the 3-D radial silhouette distribution transform and the 3-D geodesic silhouette distribution transform. Furthermore, the use of a genetic algorithm is presented for fusing information from different feature extractors. Specifically, three new feature extraction techniques are proposed: the two of them are based on the generalized radon transform, namely the radial integration transform and the circular integration transform, and the third is based on the weighted Krawtchouk moments. Extensive experiments carried out on USF ldquoGait Challengerdquo and proprietary HUMABIO gait database demonstrate the validity of the proposed scheme.

Computational competitions are the standard for benchmarking medical image analysis algorithms, but they typically use small curated test datasets acquired at a few centers, leaving a gap to the reality of diverse multicentric patient data. To this end, the Federated Tumor Segmentation (FeTS) Challenge represents the paradigm for real-world algorithmic performance evaluation. The FeTS challenge is a competition to benchmark (i) federated learning aggregation algorithms and (ii) state-of-the-art segmentation algorithms, across multiple international sites. Weight aggregation and client selection techniques were compared using a multicentric brain tumor dataset in realistic federated learning simulations, yielding benefits for adaptive weight aggregation, and efficiency gains through client sampling. Quantitative performance evaluation of state-of-the-art segmentation algorithms on data distributed internationally across 32 institutions yielded good generalization on average, albeit the worst-case performance revealed data-specific modes of failure. Similar multi-site setups can help validate the real-world utility of healthcare AI algorithms in the future.

This paper presents work conducted toward the biosignals-based automatic recognition of boredom, induced during video-game playing. For this purpose, common biosignal feature extraction methods were exploited and their capability to identify boredom was assessed. Moreover, for the first time, Legendre and Krawtchouk moments, as well as novel moment variations, were extracted as biosignal features and their potential toward automatic affect recognition was examined using the specific application scenario. The present analysis was conducted with ECG and GSR data collected from 19 different subjects, while boredom was naturally induced during the repetitive playing of a 3D video game. Conventional biosignal features as well as moment-based ones were found to be effective for the automatic recognition of boredom by achieving classification accuracies around 85 percent. Then, the joint use of moments and moment variations with conventional features was found to significantly improve classification accuracy by producing a maximum correct classification ratio of 94.17 percent.