Candidozyma auris, recently taxonomically reclassified, represents an emerging multidrug-resistant fungal pathogen that has evolved into a critical nosocomial and global public health threat. This organism exhibits a profound capacity for resilient biofilm formation on biotic and abiotic surfaces, leading to severe systemic infections with highly constrained therapeutic options. This report describes a rare, highly challenging case of a C. auris-associated prosthetic joint infection (PJI) in a diabetic patient, representing the 5th analogous documented case (and the 17th osteoarticular infection overall) in the medical literature. The clinical course was characterized by an initial failure to respond to standard echinocandin monotherapy, necessitating the escalation to a synergistic combination regimen. Although temporary microbiological and clinical clearance was achieved, the patient ultimately succumbed to multi-organ failure secondary to a subsequent Gram-negative septic outbreak. Fungal PJIs remain rare clinical entities associated with extreme morbidity and treatment failure. This systematic review emphasizes the crucial need for enhanced infection control strategies and specialized therapeutic protocols as C. auris infections continue to rise within everyday clinical environments.

Tuberculosis remains the world’s top fatal infectious disease, causing more than 1.5 million deaths globally annually, especially in low and/or middle-income countries. Greece, although still considered to be a low prevalence country according to the National and Global Report data, has experienced an epidemiological rise in the post covid era. A major limitation in the identification of the true epidemiological burden is the underreporting, especially of probable cases. The aim of this 4-year retrospective, epidemiological study was to record all newly diagnosed patients with active tuberculosis in a large, tertiary hospital of Northern Greece with their epidemiological and clinical characteristics. The temporal trend of newly diagnosed cases was identified and compared with the reports of the corresponding National Surveillance data. A total of 45 patients were identified with active tuberculosis in the years 2022-2025 with a mean symptom duration of 45 days prior to diagnosis. The patients were mostly adults (≥18 years, 74%), male (66%), of 39 years median age, and 67% natives, of Greek origin. In 38% of the patients the manifestations were exclusively extrapulmonary, more frequently so in the native population. Three strains (6,6%) were rifampicin resistant. This real-world epidemiological study provides a direct reflection of the presentation and prevalence of tuberculosis in the community, describes the clinical spectrum and the available diagnostic approaches, and identifies potential weaknesses of the Health Surveillance system.