Contemporary labor pathologies—burnout, quiet quitting, workaholism, and their global equivalents—are not marginal dysfunctions of an otherwise functional system but symptoms of a deeper anthropological failure. This article argues that the dominant framework for understanding work, grounded in the logic of interest and non-tuism, forecloses the sacrificial and participative dimensions of human action that make work genuinely humanizing. Drawing on critiques from economic theory (Bruni, Van Stichel), philosophical genealogy (Milbank, Cavanaugh, Giussani), and social phenomenology (López Quintás, Han), we identify a common root: the reduction of the worker to an immanent subject stripped of the mediating bonds of belonging. Against this diagnosis, we propose a rereading of sacrifice—moving beyond its archaic reading as a technology of control (Hubert and Mauss, Girard) toward the structure of an irrevocable gift—and articulate the category of participation in its critical–genealogical (Milbank, Cavanaugh) and relational–phenomenological (López Quintás) registers. Giussani’s notion of virginity as an existential attitude and Cavanaugh’s ecclesiology of intermediate bodies then allow us to argue that the soteriological dimension of work is only possible from within a prior experience of gratuity—a claim confirmed by the social teaching of John Paul II and Benedict XVI—and is not a nostalgic project but an economic necessity.