Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder affecting up to 10% of women of reproductive age, with significant physical and psychological consequences. This study aimed to investigate the prevalence of adult separation anxiety in women with PCOS. The secondary objective was to investigate the relationship between ASA (Adult Separation Anxiety) symptoms and the levels of depression, anxiety, stress, and intolerance of uncertainty. This cross-sectional study included 114 women with PCOS. Participants were administered the Sociodemographic Data Form, Adult Separation Anxiety Scale (ASA-27), Depression Anxiety Stress Scale (DASS-21) and Intolerance of Uncertainty Scale (IUS-12). Data were analyzed using SPSS 22.0 with Mann-Whitney U, chi-square tests, and Spearman correlations (significance set at p < 0.05). The findings revealed that 28.9% of women with PCOS exhibited separation anxiety symptoms above the cut-off score of 25. These symptoms were significantly correlated with elevated levels of stress, anxiety, depression, and intolerance of uncertainty. Moreover, individuals with separation anxiety above the cut-off score demonstrated notably higher levels of anxiety, depression, stress, and intolerance of uncertainty compared to those below the cut-off score. They also exhibited greater rates of clinical symptoms such as weight gain, acne, and infertility, as well as higher levels of testosterone, DHEAS, and LH/FSH ratio. Adult separation anxiety may be relatively common among women with PCOS and may be linked to both psychological distress and hormonal/metabolic characteristics.These findings suggest that considering ASA during psychological assessments of PCOS could be valuable and warrant further investigation through longitudinal research.

Objective: In this study, we aimed to investigate the role of peripheral blood parameters and the systemic inflammatory index (SII) in the diagnosis of hyperemesis gravidarum (HG) and whether they have a predictive value in determining the length of hospital stay and the risk of rehospitalization in HG cases. Materials and methods: In the retrospective study, pregnant women who were hospitalized due to HG (n = 112) and pregnant women who were completely healthy (n = 112) were matched for gestational age. Peripheral blood inflammation parameters of the entire study group were evaluated. The length of hospital stay and rehospitalization rate for HG cases were recorded. A total of 224 patients, 112 (50%) in the control group and 112 (50%) in the HG group were included in the study. There was a positive correlation between increased ketonuria and length of hospitalization, peripheric blood parameters, and SII. The degree of ketonuria was found to be statistically insignificant in determining the risk of rehospitalization (p = 0.927). About 28.57% (n = 32) of all HG cases were readmitted to the hospital. When the length of hospital stay was considered, SII was found to be statistically significant in hospitalizations lasting more than 2 days (p = 0.001), but not in rehospitalizations (p = 0.3). Conclusion: SII is significant in diagnosing and determining hospitalization of HG. It is sufficient to determine the length of hospital stay but not rehospitalization risk, which is an indicator of disease severity. Key words: hyperemesis gravidarum – hospitalization – inflammation markers – systemic inflammatory index