This study aimed to compare “non-treated” versus “levotriiodothyronine (LT3)-treated” protocols of short-term hypothyroidism induction prior to radioactive iodine (RAI) ablation therapy in differentiated thyroid cancer (DTC). A total of 120 DTC patients who had thyroxine withdrawal either via 4-week hypothyroidism induction (non-treated group, n=60) or 2-week administration and then 2-week withdrawal of LT3 (LT3-treated group, n=60) to induce hypothyroid state prior to RAI ablation after initial surgery were included. Complications related to hypothyroidism-induction, Beck Depression Inventory (BDI), Hospital Anxiety-Depression Scale (HADS), and SF-36 health-related quality of life (HRQoL) scores were recorded. In the non-treated group, transition from euthyroid to hypothyroid state was associated with significant increase in the likelihood of moderate-to-severe depression on BDI (p<0.001), presence of depression on HADS-D (p<0.001), presence of anxiety on HADS-A (6.7% during euthyroid state vs. 33.3% during hypothyroid state, p<0.001), and major syndrome on BPRS (0.0 vs. 10.0%, p=0.001) as well as significant decrease in all SF-36 HRQoL domain scores (p<0.001 for each). In conclusion, our findings indicate the likelihood of L3-treatment to enable a more favorable transition period from euthyroid to hypothyroid state without experiencing a deterioration in depression, anxiety, or HRQoL.

The objective of this study was to examine the effects of orlistat use on metabolic control and weight loss in diabetic and nondiabetic patients.

Aims: The utilization of levotriiodothyronine (LT3) during hypothyroidism induction remains relatively unexplored in patients with differentiated thyroid carcinoma (DTC). This study aimed to compare laboratory findings for ‘non-treated’ versus ‘LT3 treated’ protocols of short-term hypothyroidism induction in patients with DTC. Methods: A total of 130 patients with DTC who had thyroxine withdrawal to induce hypothyroid state prior to RAI ablation after initial surgery were included in this retrospective study. Patients were divided into two groups based on characteristics of thyroxine withdrawal period including those followed without treatment during the entire hypothyroidism induction period (non-treated group, n=67) and those followed with administration and then discontinuation of LT3 for the last 2 weeks of induction (LT3-treated group, n=63). Results: Not-treated vs. LT3-treated patients had significantly lower post-induction platelet counts (p=0.001) and smaller increase in platelet counts from baseline (p=0.005), higher increase from baseline total cholesterol (p=0.025), greater decrease in Ca from baseline (p=0.032), greater increase from baseline creatinine (p=0.041) and higher post-induction TSH (p=0.021). Conclusion: In conclusion, ‘LT3 treatment strategy’ seems to have several advantages over ‘no treatment strategy’ during short-term hypothyroidism induction in terms of reducing the risk of laboratory abnormalities such as milder raise in serum creatinine, calcium and total cholesterol levels, while ensuring the effective stimulation of endogenous TSH levels sufficient for radioiodine therapy.

Endokrin sistem; vücudumuzun en büyük mesajlaşma sistemi olup hücre ve organlar arası koordinasyonu sağlamaktadır. Endokrinoloji hakkındaki ilk çalışmalar Çin'de M.Ö. 200 yıllarında insan idrarından gelen seks ve hipofiz hormonlarını izole edilmesiyle başlamış ve bunlar tıbbi amaçlarla kullanmışlardır. Ülkemiz için endokrinoloji biliminin tarihi Osmanlı İmparatorluğu dönemine dayanmaktadır. Endokrinoloji ve metabolizma hastalıkları bilimi cumhuriyetin kuruluşu ile birlikte büyük bir ivme kazanmış ve günümüzdeki çağdaş halini almıştır. Tedavisi olmayan ölümcül bir hastalık olarak kabul edilen diabetes mellitusu, ölümcül olmaktan çıkaran mucize ilaç insülinin keşfedilmesi uzun yıllar bilim adamlarını uğraştırmış ve yeni bir ilacın keşfedilmesi konusunda yeri doldurulamayacak önemli deneyim ve bilgiler ortaya çıkmıştır.

Temel Besin Öğeleri Handan DUMAN Sıvı Dengesi Kamil KONUR Beslenmenin Değerlendirilmesi Şükriye Hüma TAŞÇI Sağlıklı Bireylerde Beslenme Bayram KIZILKAYA Geriatrik Hastada Beslenme Şükriye Hüma TAŞÇI Obezitede Beslenme Meliha Melin UYGUR Diyabetik Hastalarda Beslenme Damla TÜFEKÇİ Dislipidemide Beslenme Bayram KIZILKAYA Romatolojik Hastalıklarda Beslenme Osman CÜRE Kronik Böbrek Yetmezliği Hastalarında Beslenme Özge TEKDEMİR Ekrem KARA Kardiyolojide Beslenme Hüseyin DURAK Akciğer Hastalıklarında Beslenme Songül ÖZYURT Kronik Karaciğer Hastalıklarında Beslenme Halil ATASOY Malabsorbsiyonlu Hastada Beslenme Serdar DURAK Süheyla RAHMAN Kanser Hastalarında Beslenme Kadir İLKKILIÇ Kritik Hastalarda Beslenme Güleren YARTAŞ DUMANLI Yatan Hastalarda Enteral Beslenme Hatice BEYAZAL POLAT Yatan Hastalarda Sıvı Tedavisi Kamil KONUR Parenteral Beslenme Hatice BEYAZAL POLAT