In this study, three pressure retarded osmosis (PRO) power plants are proposed to be built on the Red Sea–Dead Sea (RSDS) water conveyance project, to generate power from the salinity gradient between two water streams at different salt concentrations. The first two proposed plants are to be built after sea water reverse osmosis (SWRO) desalination plants, where Red Sea water and the rejected brine from SWRO plants are used as feed and draw solutions, respectively. In the third proposed plant, Red Sea water and Dead Sea water will be used. Results showed that the three proposed plants are technically feasible while the third plant is the only one that is economically feasible with a 134.5 MW capacity and a 0.056 $/KWh levelized cost of electricity (LCE). The power generated from the third PRO power plant accounts for about 24.7% of the power needed for the RSDS project that can be used to power SWRO-2 in order to reduce the electricity consumption by 49.3%. If the generated power from the proposed PRO plant is sold to the Jordanian national electricity grid at the current selling price in accordance with Jordanian prices of electricity, a saving of about 21.2% can be attained. It is found that using the power generated by the current proposed plants for desalination project purposes will significantly reduce the price of desalinated water produced from SWRO desalination plants.