Crop residue plays a vital role in maintaining soil health, reducing erosion, enhancing water retention, and contributing to carbon sequestration in agricultural systems. Accurate estimation of crop residue biomass is essential for understanding its distribution patterns, advancing sustainable agricultural practices and improving land management. This study integrates high-resolution UAV multispectral imagery, advanced feature selection methods, and machine learning models to develop a scalable framework for crop residue biomass prediction. An ensemble model, combining predictions from CatBoost, Support Vector Regression, Random Forest, and K-Nearest Neighbor, was created and compared to these individual models to evaluate its performance for predicting crop residue biomass. A variety of predictor variables, including spectral indices, topographic features, textural features, and raw bands, were used in these models. To improve modeling efficiency and accuracy, four feature selection techniques—Recursive Feature Elimination, Pearson correlation, Least Absolute Shrinkage and Selection Operator regression—were tested and compared to identify the most relevant predictor features. Results show that red band and variance from the blue band emerged as consistently selected top predictors across methods. Additionally, the results highlighted the importance of integrating topographic and textural features alongside spectral features to enhance crop residue biomass estimation accuracy. The ensemble approach, combined with Recursive Feature Elimination-selected features, produced the most accurate crop residue biomass predictions (R 2 = 0.425, RMSE = 243.465 g/ha). This study demonstrates the potential of ensemble models with optimized feature selection to enhance crop residue monitoring for precision agriculture and sustainable land management.