Hybrid nanocomposites offer promising alternatives for the treatment of various diseases by enabling multifunctional therapeutic strategies. In this work, a hybrid nanocomposite based on hollow bimetallic nanoparticles (HBNPs) coated with poly(N-isopropylacrylamide) (PNIPAM) was designed as a stimuli-responsive platform for controlled drug delivery and photothermal therapy. This system exploits the strong near-infrared absorption of HBNPs and the thermoresponsive behavior of PNIPAM, which undergoes reversible swelling-contraction transitions that regulate drug release. The successful synthesis of the nanocomposite with combined chemotherapeutic and photothermal functionality was demonstrated. The nanocomposite exhibited stable and reproducible photothermal performance, generating sufficient temperature increases to induce cell death via hyperthermia. In addition, the platform showed low intrinsic cytotoxicity and favorable properties as a drug carrier for doxorubicin. Drug release displayed clear pH dependence reaching cumulative values of 84% of its load at pH 5.5 and 76% at physiological pH (7.4) after 24 h. Furthermore, NIR laser irradiation enhanced drug release up to 90% within the same period. In all cases, doxorubicin encapsulation improved therapeutic efficacy, which was further amplified when combined with laser irradiation. Overall, these results demonstrate the potential of the nanocomposite as an effective dual-modality platform for controlled, stimuli-responsive chemo-photothermal therapy.