City networks refer to the connections of physical or virtual flows among cities at different spatial scales, including population migration networks, economic networks, information networks and innovation networks. This concept has gradually evolved into an important paradigm for understanding the regional spatial structures. Based on Baidu Index data within the Yangtze River Economic Belt (YREB) in China, this paper constructs an information network and investigates its connection patterns. Using social network analysis, the structural differentiation of the information network is further investigated at both the overall and subregional scales. The results show that the connection patterns of the information network exhibit an obvious hierarchical structure, with the complexity of the spatial pattern gradually increasing from the upstream to the downstream regions. Furthermore, the structural assessment results suggest that the information network is characterized by high agglomeration, high mobility, high hierarchy and low disassortativity. These findings indicate that the information network in the YREB is dominated by several highly developed core city clusters. However, the inherently closed structure resulting from these characteristics may not be sufficiently counterbalanced by low disassortativity. Under sudden disturbances, such a structural configuration may exhibit limited adaptability, delayed response capacity, and slow reorganization and learning processes, thereby weakening structural resilience. This study provides a deeper understanding of intercity relationships within the YREB and offers policy implications for enhancing structural resilience across the Yangtze River Basin.