Most patients with unilateral diaphragm paralysis (UDP) have unexplained dyspnea, exercise limitations, and reduction in inspiratory muscle capacity. We aimed to evaluate the generation of pressure in each hemidiaphragm separately and its contribution to overall inspiratory strength. Twenty-seven patients, 9 in right paralysis group (RP) and 18 in left paralysis group (LP), with forced vital capacity (FVC) < 80% pred, and 20 healthy controls (CG), with forced expiratory volume in 1 s (FEV₁) > 80% pred and FVC > 80% pred, were evaluated for lung function, maximal inspiratory (MIP) and expiratory (MEP) pressure measurements, diaphragm ultrasound, and transdiaphragmatic pressure during magnetic phrenic nerve stimulation (Pdi_Tw). RP and LP had significant inspiratory muscle weakness compared to controls, detected by MIP (− 57.4 ± 16.9 for RP; − 67.1 ± 28.5 for LP and − 103.1 ± 30.4 cmH₂O for CG) and also by Pdi_TW (5.7 ± 4 for RP; 4.8 ± 2.3 for LP and 15.3 ± 5.7 cmH₂O for CG). The Pdi_Tw was reduced even when the non-paralyzed hemidiaphragm was stimulated, mainly due to the low contribution of gastric pressure (around 30%), regardless of whether the paralysis was in the right or left hemidiaphragm. On the other hand, in CG, esophagic and gastric pressures had similar contribution to the overall Pdi (around 50%). Comparing both paralyzed and non-paralyzed hemidiaphragms, the mobility during quiet and deep breathing, and thickness at functional residual capacity (FRC) and total lung capacity (TLC), were significantly reduced in paralyzed hemidiaphragm. In addition, thickness fraction was extremely diminished when contrasted with the non-paralyzed hemidiaphragm. In symptomatic patients with UDP, global inspiratory strength is reduced not only due to weakness in the paralyzed hemidiaphragm but also to impairment in the pressure generated by the non-paralyzed hemidiaphragm.

Introduction: Chronic respiratory conditions, such as COPD and ILD, frequently lead to exertional dyspnoea and a notable decline in quality of life. Study Design: We compared respiratory muscle strength, respiratory pressures, work of breathing (WOB), and dyspnoea during incremental exercise in COPD, ILD, and healthy controls (n=20 each). Results: Both diseases showed poor performance, with high values of transdiaphragmatic pressure (PDi) and WOB, but with different profiles. 1) In ILD, there was a higher increase in oesophageal pressure (PEs) and a lower gastric pressure (PGa), whereas in COPD, there was a significant increase in PGa. 2) In COPD, there was a greater increase in resistive and expiratory WOB, whereas in ILD, the elastic WOB was the most increased. 3) The neuromechanical inefficiency of ventilation was confirmed in both diseases (decrease in the Vt/PDi ratio). Conclusion: COPD and ILD had reduced exercise performance and high breathlessness in face to increased values of diaphragm strength. However, the mechanisms of muscle recruitments differ between both respiratory diseases.