Prof. Dr. Timoleon-Achilleas Vyzantiadis
Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Thessaloníki, Kentrikí Makedonía, Greece
'%3e%3cpath%20d='M22.1642%2019.0924C21.7317%2018.068%2021.1041%2017.1375%2020.3163%2016.3527C19.5309%2015.5656%2018.6006%2014.9381%2017.5766%2014.5048C17.5674%2014.5002%2017.5582%2014.4979%2017.5491%2014.4933C18.9774%2013.4616%2019.9059%2011.7811%2019.9059%209.88504C19.9059%206.74408%2017.3611%204.19922%2014.2201%204.19922C11.0792%204.19922%208.53429%206.74408%208.53429%209.88504C8.53429%2011.7811%209.46282%2013.4616%2010.8912%2014.4956C10.882%2014.5002%2010.8728%2014.5025%2010.8636%2014.5071C9.83652%2014.9404%208.91487%2015.5617%208.1239%2016.355C7.33685%2017.1404%206.70933%2018.0707%206.276%2019.0947C5.85031%2020.0972%205.62072%2021.172%205.59967%2022.2609C5.59905%2022.2853%205.60335%2022.3097%205.61229%2022.3325C5.62123%2022.3553%205.63465%2022.376%205.65174%2022.3935C5.66883%2022.4111%205.68926%2022.425%205.71182%2022.4345C5.73437%2022.444%205.7586%2022.4489%205.78308%2022.4489H7.15868C7.25956%2022.4489%207.3398%2022.3686%207.3421%2022.2701C7.38795%2020.5001%208.09868%2018.8425%209.35506%2017.5861C10.655%2016.2862%2012.3814%2015.5709%2014.2201%2015.5709C16.0588%2015.5709%2017.7852%2016.2862%2019.0852%2017.5861C20.3415%2018.8425%2021.0523%2020.5001%2021.0981%2022.2701C21.1004%2022.3709%2021.1807%2022.4489%2021.2815%2022.4489H22.6571C22.6816%2022.4489%2022.7058%2022.444%2022.7284%2022.4345C22.751%2022.425%2022.7714%2022.4111%2022.7885%2022.3935C22.8056%2022.376%2022.819%2022.3553%2022.8279%2022.3325C22.8369%2022.3097%2022.8412%2022.2853%2022.8406%2022.2609C22.8176%2021.165%2022.5907%2020.0989%2022.1642%2019.0924ZM14.2201%2013.8284C13.1678%2013.8284%2012.1773%2013.418%2011.4322%2012.6729C10.6871%2011.9278%2010.2767%2010.9374%2010.2767%209.88504C10.2767%208.83271%2010.6871%207.84227%2011.4322%207.09715C12.1773%206.35204%2013.1678%205.94165%2014.2201%205.94165C15.2724%205.94165%2016.2629%206.35204%2017.008%207.09715C17.7531%207.84227%2018.1635%208.83271%2018.1635%209.88504C18.1635%2010.9374%2017.7531%2011.9278%2017.008%2012.6729C16.2629%2013.418%2015.2724%2013.8284%2014.2201%2013.8284Z'%20fill='%238590A2'/%3e%3c/g%3e%3c/svg%3e)
Co-authors
Following
Followers
Research Focus & Metrics
Explore full metrics on Scilit
Academic Career Length
25Years (2002-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications
Journal Article
IVIoannis Ventoulis
Ioannis VentoulisTSTheopisti Sarmourli
Theopisti SarmourliPAPinelopi Konstantinos Amoiridou
Pinelopi Konstantinos AmoiridouPMPARASKEVI MANTZANA
PARASKEVI MANTZANAMEMaria Exindari
Maria ExindariTimoleon-Achilleas Vyzantiadis +1
Co-infections have an unknown impact on the morbidity and mortality of the new clinical syndrome called coronavirus disease 2019 (COVID-19). The syndrome is caused by the new pandemic coronavirus SARS-CoV-2 and it is probably connected with severe traces in the elements of the immune system. Apart from possible Aspergillus infections, particularly in patients with acute respiratory distress syndrome (ARDS), other fungal infections could occur, probably more easily, due to the immunological dysregulation and the critical condition of these patients. Probiotic preparations of Saccharomyces are broadly used for the prevention of antibiotic-associated complications, especially in the intensive care units (ICU). On the other hand, Saccharomyces organisms are reported as agents of invasive infection in immunocompromised or critically ill patients. We report two cases of bloodstream infection by Saccharomyces in two patients hospitalised in the ICU, due to severe COVID-19, after Saccharomyces supplementation.
22 December 2014 in Journal of Immunology Research
Journal Article
AKAikaterini Kyriakou
Aikaterini KyriakouAPAikaterini Patsatsi
Aikaterini Patsatsi
Timoleon-Achilleas VyzantiadisDSDimitrios Sotiriadis
Dimitrios Sotiriadis
A case-control study was performed to assess the serum levels of TNF-α, IL-12/23p40, and IL-17 in patients with plaque psoriasis, compare them with healthy controls, and correlate them with disease severity, as represented by Psoriasis Area Severity Index (PASI). 32 consecutively selected, untreated patients with active, chronic plaque psoriasis were recruited and compared to 32 age- and sex-matched healthy controls. Serum cytokine levels were determined by solid phase sandwich enzyme linked immunosorbent assay (R&D Systems Europe, Ltd.). The mean serum levels of TNF-αwere significantly higher in psoriatic patients compared to those of controls (Mann-Whitneytest;. However, the median serum levels of neither IL-12/23p40 nor IL-17 differ significantly between the 2 groups (Mann-Whitneytest;and, resp.). No significant correlations were found between PASI and any of the cytokine serum levels (Spearman’s rank test;. Despite the well-evidenced therapeutic efficacy of biologic agents targeting TNF-α, IL-12/23p40, and IL-17, serum levels of TNF-α, IL-12/23p40, and IL-17 do not seem to correlate with the severity of psoriatic skin disease in untreated patients, as represented by PASI. Further investigation may add more data on the pathogenetic cascade of psoriasis.
1 January 2012 in Thrombosis and Haemostasis
Journal Article
SVSofia Vakalopoulou
Sofia Vakalopoulou
ASAristidis Slavakis
Aristidis Slavakis
MCMaria Charizopoulou
Maria Charizopoulou
EKEirini Kazantzidou
Eirini Kazantzidou
TCTania Chrysopoulou
Tania Chrysopoulou
Panagiotis Anagnostis +4
Summary: Haemophilia A and B has been associated with increased prevalence of low bone mass (67–86%). The aim of this study was to estimate the prevalence of bone disease in haemophiliacs and its association with potential risk factors. Adult patients with haemophilia A and B followed-up in the Haemophilia Centre of Northern Greece were included. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry (DXA) in lumbar spine (LS), femoral neck (FN), total hip (TH) and great trochanter (GT). One-hundred four male patients (aged 45.8 ± 15.1 years) and 50 controls (aged 44.9 ± 12.8 years) were screened. Low BMD was diagnosed in 28 patients (26.9%) and 10 controls (20%) (p=0.0001). Patients had lower BMD in TH (p=0.007), FN (p=0.029) and GT (p=0.008) than controls, without differences in LS. BMD was positively associated with the severity of haemophilia, history of herpes virus C or human immunodeficiency virus and level of physical activity, and negatively with the level of arthropathy. In multiple-regression analysis, only the level of physical activity and 25-hydroxyvitamin D [25(OH)D] significantly predicted BMD. Half of the patients had vitamin D deficiency. In conclusion, our study showed increased prevalence of low BMD in haemophiliacs. The levels of physical activity and 25(OH)D independently predicted low BMD.
1 June 2011 in Antimicrobial Agents and Chemotherapy
Journal Article
MAMichael Arabatzis
Michael ArabatzisMKManousos Kambouris
Manousos Kambouris
MKMiltiades Kyprianou
Miltiades KyprianouACAikaterini Chrysaki
Aikaterini Chrysaki
MFMaria Foustoukou
Maria Foustoukou
AVAristea Velegraki
Aristea Velegraki
+13
In this study, the first such study in Greece, we used polyphasic identification combined with antifungal susceptibility study to analyze Aspergillus clinical isolates comprising 102 common and rare members of sections Fumigati, Flavi, Terrei, Nidulantes, Nigri, Circumdati, Versicolores, and Usti. High amphotericin B MICs (>2 μg/ml) were found for 17.6% of strains. Itraconazole, posaconazole, and voriconazole MICs of >4 μg/ml were shown in 1%, 5%, and 0% of the isolates, respectively. Anidulafungin, micafungin, and caspofungin minimum effective concentrations (MECs) of ≥2 μg/ml were correspondingly recorded for 4%, 9%, and 33%, respectively, of the strains.
19 February 2015 in Archives of Gynecology and Obstetrics
Journal Article
MKMichail Kalinderis
Michail Kalinderis
APAlexis Papanikolaou
Alexis Papanikolaou
Kallirhoe KalinderiTimoleon-Achilleas VyzantiadisAIAliki Ioakimidou
Aliki Ioakimidou
BTBasil C. Tarlatzis
Basil C. Tarlatzis
Journal Article
AMAnthi Marina Markantonatou
Anthi Marina MarkantonatouKSKonstantinos Samaras
Konstantinos SamarasTimoleon-Achilleas VyzantiadisMicrobes are found in the environment, possibly more often as biofilms than in planktonic forms. Biofilm formation has been described for several important fungal species. The presence of a dermatophytoma in a dermatophytic nail infection was the basis for the proposal that dermatophytes form biofilms as well. This could explain treatment failure and recurrent dermatophytic infections. Several investigators have performed in vitro and ex vivo experiments to study the formation of biofilms by dermatophytes and their properties. The nature of the biofilm structure itself contributes to fungal protection mechanisms against many harmful external agents, including antifungals. Thus, a different approach should be carried out regarding susceptibility testing and treatment. Concerning susceptibility testing, methods to evaluate either the inhibition of biofilm formation, or the ability to eradicate it, have been introduced. As for treatment, in addition to classical antifungal agents, some natural formulations, such as plant extracts or biosurfactants, and alternative approaches, such as photodynamic therapy, have been proposed. Studies that connect the results of the in vitro and ex vivo experimentation with clinical outcomes are required in order to verify the efficacy of these approaches in clinical practice.
About Me
Timoleon-Achilleas Vyzantiadis is a medical specialist in Medical Biopathology at the Medical School of the Aristotle University of Thessaloniki, Greece.
He is a professor of Medical Biopathology-Microbiology, director of the Department of Microbiology and the head of the Laboratory for the diagnosis and monitoring of fungal infections (Medical Mycology Reference Laboratory).
He has spent further postgraduate training-working periods and a sabbatical at the following institutions:
Mycology Unit, Department of Microbiology, Medical School of Athens,
British Mycology Reference Laboratory, Bristol, U.K.,
Centre for Medical Microbiology, University College of London and Department of Medical Microbiology, Royal Free Hospital, London, U.K.
He has attended and participated in more than 50 postgraduate seminars and courses (mostly connected to Laboratory Medicine). He has presented and/or participated with abstracts at more than 150 national and international medical congresses or scientific meetings and published more than hundred full publications in national or international scientific journals and books.
His memberships in medical-scientific societies include the Hellenic Society of Medical Mycology, ISHAM (International Society of Human and Animal Mycology), the British Society for Medical Mycology, the Medical Society of Thessaloniki and the Society of Medical Biopathology of Northern Greece.