Jarosław Jóźwiak

Dr. Jarosław Jóźwiak

Psychiatry, ALMA Therapy Centre, Warsaw, Mazowieckie, Poland
orcid

Research Focus & Metrics

Academic Career Length

30Years (1997-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 January 2008 in The Lancet Oncology
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Journal Article
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Jarosław JóźwiakJarosław Jóźwiak
Jarosław Jóźwiak
Sergiusz JóźwiakSergiusz Jóźwiak
Sergiusz Jóźwiak
PWPawel K. Wlodarski
Pawel K. Wlodarski

1 February 2006 in Journal of Reproductive Immunology
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Journal Article
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USUrszula Stopińska-Głuszak
Urszula Stopińska-Głuszak
JWJacek Waligóra
Jacek Waligóra
TGTomasz Grzela
Tomasz Grzela
MGMichał Głuszak
Michał Głuszak
Jarosław JóźwiakJarosław Jóźwiak
Jarosław Jóźwiak
JMJacek Malejczyk
Jacek Malejczyk

26 October 2005 in International Journal of Cancer
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Jarosław JóźwiakJarosław Jóźwiak
Jarosław Jóźwiak

1 January 2005 in NeuroMolecular Medicine
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Jarosław JóźwiakJarosław Jóźwiak
Jarosław Jóźwiak
Sergiusz JóźwiakSergiusz Jóźwiak
Sergiusz Jóźwiak
TGTomasz Grzela
Tomasz Grzela
MLMaciej Lazarczyk
Maciej Lazarczyk

1 March 2009 in Pediatric and Developmental Pathology
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KKKatarzyna Kotulska-Jóźwiak
Katarzyna Kotulska-Jóźwiak
MLMagdalena Larysz-Brysz
Magdalena Larysz-Brysz
WGWieslława Grajkowska
Wieslława Grajkowska
Jarosław JóźwiakJarosław Jóźwiak
Jarosław Jóźwiak
PWPawel K. Wlodarski
Pawel K. Wlodarski
Sergiusz JóźwiakSergiusz Jóźwiak
Sergiusz Jóźwiak
Cardiac rhabdomyoma (CR) is the most common heart tumor in children and is usually associated with tuberous sclerosis complex (TSC). Tuberous sclerosis complex is a genetic disorder caused by a mutation in either of 2 genes (TSC1 or TSC2) and characterized by the formation of hamartomas in multiple organs. The 2 TSC proteins, hamartin and tuberin, antagonize the mammalian target of rapamycin (mTOR) signaling pathway, thus regulating cell growth and proliferation. Recently, some trials treating TSC with the mTOR inhibitor rapamycin have been published; however, the impact of such treatment on heart tumors is not known. The aim of the present paper was to study the molecular pathobiology of CRs. Six CR samples were studied. The expression of S6K1, pErk, Erk, Akt, pAkt, 4E-BP1, hamartin, tuberin, mTOR, bcl-2, Bax, and Ki-67 was examined using immunohistochemistry and Western blot methods. Increased expression of Bax, mTOR, pS6K, pErk, and 4E-BP1 was found in all CR samples. Hamartin and tuberin expression was decreased in tumors versus normal heart tissues. This is the first study showing mTOR pathway dysregulation and an increased expression of proapoptotic Bax protein in CRs associated with TSC.

2 December 2005 in Medicinal Research Reviews
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Jarosław JóźwiakJarosław Jóźwiak
Jarosław Jóźwiak
Sergiusz JóźwiakSergiusz Jóźwiak
Sergiusz Jóźwiak
MOMonika Oldak
Monika Oldak