Introduction: Heart failure (HF) is a major chronic condition associated with high morbidity, mortality, and reduced quality of life (QoL). Self-care behaviors based on Orem’s theory play a critical role in symptom management and in improving health-related QoL. Aim: This study aimed to examine the relationship between self-care and quality of life among patients with heart failure based on Orem’s Self-Care Theory.Method: Research design: A descriptive correlational research design was employed at the Heart Center of Al-Qurayyat General Hospital in Saudi Arabia. Sampling: A purposive sample included 100 adult HF patients classified as New York Heart Association (NYHA) Class II or III. Tool: Data was collected using a structured questionnaire: The questionnaire consisted of three main sections: Patients’ demographic and clinical data, the heart failure-specific health-related quality of life scale, and the European heart failure self-care behavior scale.Results: Nearly two-thirds of participants (64%) demonstrated good self-care, 26% moderate, and 10% poor self-care. The mean self-care score was 26.81 ± 9.69, indicating moderate adherence. The overall mean QoL score was 1.74 ± 0.85, indicating mild to moderate impairment. Self-care was significantly and positively correlated with all QoL domains—physical (r = 0.369, p < 0.01), emotional (r = 0.383, p < 0.01), social (r = 0.268, p < 0.01), and total QoL (r = 0.360, p < 0.01). Conclusion: Incorporating Orem’s Self-Care framework into nursing interventions could enhance patients’ self-care management, reduce disease burden, and improve overall well-being.

Smoking cessation is particularly challenging among patients with chronic diseases because nicotine dependence and established smoking behaviors may hinder