Numerous genetic pathways associated with glioblastoma development have been identified. In this study, we investigated the prognostic significance of IDH1 and ATRX mutations and WT-1 and p53 expression in glioblastomas and that of surgical methods, radiotherapy and chemotherapy. 83 patients with...

Background Recent studies suggest that large language models (LLMs) such as ChatGPT are useful tools for medical students or residents when preparing for examinations. These studies, especially those conducted with multiple-choice questions, emphasize that the level of knowledge and response consistency of the LLMs are generally acceptable; however, further optimization is needed in areas such as case discussion, interpretation, and language proficiency. Therefore, this study aimed to evaluate the performance of six distinct LLMs for Turkish and English neurosurgery multiple-choice questions and assess their accuracy and consistency in a specialized medical context. Methods A total of 599 multiple-choice questions drawn from Turkish Board examinations and an English neurosurgery question bank were presented to six LLMs (ChatGPT-o1pro, ChatGPT-4, AtlasGPT, Gemini, Copilot, and ChatGPT-3.5). Correctness rates were compared using the proportion z-test, and inter-model consistency was examined using Cohen’s kappa. Results ChatGPT-o1pro, ChatGPT-4, and AtlasGPT demonstrated relatively high accuracy for Single Best Answer–Recall of Knowledge (SBA-R), Single Best Answer–Interpretative Application of Knowledge (SBA-I), and True/False question types; however, performance notably decreased for questions with images, with some models leaving many unanswered items. Conclusion Our findings suggest that GPT-4-based models and AtlasGPT can handle specialized neurosurgery questions at a near-expert level for SBA-R, SBA-I, and True/False formats. Nevertheless, all models exhibit notable limitations in questions with images, indicating that these tools remain supplementary rather than definitive solutions for neurosurgical training and decision-making.