Limited permeability through the stratum corneum (SC) is a major obstacle for numerous skin care products. One promising approach is to use lipid nanoparticles as they not only facilitate penetration across skin but also avoid the drawbacks of conventional skin formulations. This review focuses on solid lipid nanoparticles (SLNs), nanostructured lipid nanocarriers (NLCs), and nanoemulsions (NEs) developed for topical and transdermal delivery of active compounds. A special emphasis in this review is placed on composition, preparation, modifications, structure and characterization, mechanism of penetration, and recent application of these nanoparticles. The presented data demonstrate the potential of these nanoparticles for dermal and transdermal delivery.

This study revealed a new inhibitor of Ca²⁺/calmodulin-dependent protein kinase II (CaMKII), a crucial factor in cardiovascular disease and hypertension. The study focuses on the bioactivity compounds that combine adamantane/1,3,4-oxadiazole, potentially inhibiting CaMKIIδ. Various adamantyl-1,3,4-oxadiazole derivatives were synthesized and tested for their efficiency against CaMKIIδ kinase, with 6f being the most potent with an IC₅₀ value of 14.4 μM. Docking studies were carried out to determine the binding processes of these chemicals within the kinase’s active region. These discoveries are an important step toward the development of novel treatments for cardiovascular illnesses and hypertension, with the potential for more precise and efficient therapeutic interventions in the future.

Fibroblast growth-factor receptor (FGFR) is a potential target for cancer therapy. We synthesised a novel series of FGFR1 inhibitors bearing quinoline, quinoxalin and isoquinoline using a synthetic strategy employing a one pot reaction, yielding 2-hydroxy-1H-indene-1,3(2H)-dione. Structural elucidation via IR, NMR and HRMS analyses is complemented by a proposed mechanistic pathway. All newly-synthesised compounds were evaluated in vitro for their inhibitory activities against FGFR-1. The most potent derivatives were 9a, 9b, 9c and 7b with IC₅₀ = 5.7, 3.3, 4.1 and 3.1 μM, respectively, supported by molecular docking studies which probed the binding interactions of these compounds within the active site of the kinase.

: Benzimidazole, discovered in 1872, is a heterocyclic compound noted for its pharmacological activities. It and its derivatives can be synthesized through methods such as condensation reactions and using nano-based nanoparticles as catalysts. Recent environmentally friendly methods include microwaves, ultrasound, and photochemical reactions. its derivatives are known for their diverse medicinal applications : Benzimidazole and its derivatives are versatile compounds with a wide range of pharmacological activities. Their synthesis has evolved over time, incorporating various environmentally friendly methods such as microwave, ultrasound, and photochemical reactions. The continued exploration of these compounds and their synthesis methods holds great promise for the development of new and effective medicinal applications. : Here, we provide an overview of benzimidazole, highlighting its historical significance, various synthesis methods, and extensive range of pharmacological activities. It aims to emphasize the importance of benzimidazole and its derivatives in medicinal chemistry and their potential therapeutic applications. The review also notes the development of environmentally friendly synthesis techniques, reflecting advancements in the field.