This systematic review was conducted to compare the effectiveness of different accelerated partial breast irradiation (APBI) techniques for the treatment of breast cancer patients. Numerous (APBI) techniques are available for clinical practice. Systematic review of randomized controlled trials of APBI versus whole breast irradiation (WBI). The data from APBI studies were extracted for the analyses. Indirect comparisons were used to compare different APBI techniques. Ten studies fulfilled the inclusion criteria. A total of 4343 patients were included, most of them with tumor stage T1-T2 and N0. Regarding APBI techniques, six trials used external beam radiation therapy; one intraoperative electrons; one intraoperative low-energy photons; one brachytherapy; and one external beam radiation therapy or brachytherapy. The indirect comparisons related to 5-years local control and 5-years overall survival were not significantly different between APBI techniques. Based on indirect comparisons, no differences in clinical outcomes were observed among diverse APBI techniques in published clinical trials that formally compared WBI to APBI. However wide confidence intervals and high risk of inconsistency precluded a sound conclusion. Further head-to-head clinical trials comparing different APBI techniques are required to confirm our findings. Studies comparing different techniques using individual participant data and/or real-life data from population-based studies/registries could also provide more robust results.

Radio-guided occult lesion localization is a valid technique for the diagnosis of suspicious non-palpable lesions. Here we determine the feasibility of pre-operative localization of occult suspect non-palpable breast lesions using radio-guided occult lesion localization, as well as for identifying the sentinel lymph node. This is a descriptive study of data collected retrospectively. Pre-operative mapping of 34 breast lesions in 25 patients suspected of being malignant was performed using conventional imaging methods with a magnetic resonance imaging-guided radiopharmaceutical injection. The mean time required to perform the localization was 25 minutes. After resection of the lesions using a gamma probe, malignancy was confirmed in fifteen patients (60.0%), with nine invasive ductal carcinomas, two invasive lobular carcinomas, and four in situ ductal carcinomas The resection was confirmed by the complete removal of the radioactive material. The pathologic results and images were concordant in all but two cases, which were submitted for new magnetic resonance imaging examinations and surgery that confirmed the malignancies. Of the 15 patients with confirmed malignancies, 10 had sentinel lymph node resection. Of these, eight were negative for metastases, one had micro-metastases and one had confirmed metastases. Three patients had full axillary node dissection, with metastases found in only one. No side effects were observed with magnetic resonance-guided radiopharmaceutical injection. The sentinel node occult lesion localization technique is a simple, reproducible and effective alternative approach to occult lesions compared to other methods, such as mammotomy and the hook-wire localization technique, for mapping suspect breast lesions and identifying lymph node metastasis.

This article provides description about acute toxicity and early follow-up of one patient treated for breast cancer and Schnitzler syndrome. There are no previously reported cases exploring this interaction on medical literature. The expected radiodermitis to occur in the region treated with radiotherapy along with urticarial-like lesions might be challenging in view of the interaction between symptoms and therapeutic measures.

Introduction: Core needle biopsy (CNB) is the gold standard for histopathological diagnosis of breast masses. However, rare complications may occur after undergoing CNB, including hematoma and pseudoaneurysm (PA) of the breast. Cases presentation: Case 1: 66-year-old woman with a left breast mass who underwent a CNB without complications. Around eleven months later, she noticed a palpable and pulsatile mass in her left breast. She was diagnosed with a PA (1.6x1.3 cm) by means of a Doppler ultrasound (US) and a breast magnetic resonance imaging, which was surgically resected without any complication using local anesthesia. Case 2: 44-year-old woman with a left breast mass. After undergoing CNB, she developed ecchymosis and a palpable and pulsatile mass in her left breast. A Doppler US showed a 1.4x0.7 cm cystic lesion suggestive of a breast PA. The mass was surgically resected without complications using local anesthesia and sedation. Conclusion: Breast PA is an extremely rare complication of CNB, with only 17 cases reported in PubMed to date. However, breast PA must be highly suspected in the presence of warning signs such as bleeding, hematoma and a palpable and/or pulsatile breast mass after undergoing CNB. Introducción: La biopsia por punción con aguja gruesa (CNB por su sigla en inglés) es el estándar de oro para el diagnóstico histopatológico de las masas mamarias. No obstante, complicaciones raras como hematomas y pseudoaneurisma (PA) de la mama pueden ocurrir después de este procedimiento. Presentación de los casos: Caso 1: Mujer de 66 años con una masa mamaria izquierda y a la que se le realizó una CNB sin complicaciones. Aproximadamente once meses después, notó una masa pulsátil palpable en el seno izquierdo. Mediante ecografía Doppler y resonancia magnética de las mamas se diagnosticó un PA (1.6x1.3 cm). La masa fue extirpada quirúrgicamente sin complicaciones bajo anestesia local. Caso 2: Mujer de 44 años con una masa mamaria izquierda. Después de realizarse la CNB, la paciente desarrolló equimosis y una masa pulsátil palpable en su mama izquierda. Mediante una ecografía Doppler se observó una lesión cística de 1.4x0.7 cm sugestiva de PA mamario. La masa fue extirpada quirúrgicamente sin complicaciones bajo anestesia local y sedación. Conclusión: El PA mamario es una complicación extremadamente rara de la CNB; tan solo 17 casos han sido reportados en PubMed hasta la fecha. Sin embargo, esta entidad debe ser altamente sospechada en la presencia de signos de alarma como dolor, sangrado, hematoma y una masa mamaria palpable y/o pulsátil tras la realización de una CNB.