The aim of this study is to investigate the routine blood parameters of COVID-19 patients at the time of admission to the emergency department and their relationship with the severity of the disease and prognosis. A total of 500 patients, who were diagnosed with severe COVID-19 and hospitalized in the intensive care unit between 01.04.2020 and 01.02.2021 in the emergency department of a pandemic hospital, were retrospectively analyzed. Demographic, clinical, and laboratory data of the patients were obtained from the hospital registry system. Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) were calculated using neutrophil, lymphocyte, monocyte, and platelet counts. These patients were divided into two groups: survivors and deceased. All parameters obtained from routine blood analysis were statistically compared between these two groups. While 280 out of 500 patients survived, 220 died. Of all patients, the mean age was 67 years and 51.8% were males. There was a significant difference between the two groups in terms of age, gender, length of hospital stay, need for mechanical ventilation, white blood cell, neutrophil, lymphocyte, monocyte, eosinophil, platelet counts, CRP, ferritin, procalcitonin values, NLR, MLR, and PLR ( for all). While NLR alone and MLR + NEU and NLR + PLR + MLR combinations had the highest AUC values (0.930, 0.947, and 0.939, respectively), MLR and PLR alone showed the lowest AUC values (0.875 and 0.797, respectively). The sensitivity, specificity, positive predictive values (PPVs), and negative predictive values (NPVs) in the prediction of death according to the cutoff values of the parameters have been determined. A significant correlation was determined between age, NLR, MLR, and PLR and duration of hospital stay ( for all). Routine blood parameters and NLR, MLR, and PLR can assist emergency physicians to identify the severity and early prognosis of COVID-19 patients.

Aim: The study investigated heparin-binding protein (HBP) levels in patients with severe COVID-19 pneumonia and their relation to prognosis. Methods: A total of 134 patients with serious COVID-19 p...

Purpose: The present study aimed to investigate the relationship between prognosis and the red cell distribution width (RDW) and the RDW-albumin ratio (RAR) in patients with coronavirus diseases 2019 (COVID-19), since serum albumin and RDW levels may reflect inflammatory conditions. Patients and Methods: A total of 289 patients who had been diagnosed with severe COVID-19 in the emergency department were retrospectively analyzed. The RAR levels were calculated by dividing RDW-CV by albumin. Patient groups (survivors, dying patients, those who received mechanical ventilation (MV) support or not, and those who needed vasopressors or not) were compared with regard to RDW-SD, RDW-CV and the RAR levels. Results: RDW-SD, RDW-CV and the RAR levels were found to be statistically significantly higher in patients who died, and who received MV and vasopressor support, compared to those who survived and did not receive support (p< 0.001 for all). In addition, while the cut-off value of RAR was > 5.43, the sensitivity was 91.6%, the specificity was 93.7%, NPV was 93.1% and the AUC was 0.965 in predicting mortality (p< 0.001). Logistic regression analysis showed that RDW-SD and RAR were independent risk factors for mortality in patients with severe COVID-19. Conclusion: Elevated RDW and RAR levels at the time of admission may independently predict mortality and the need for vasopressor or MV support.

Viral infections of the respiratory tract are generally related to many factors such as excessive production of cytokines, inflammation, cellular death, redox imbalance or oxidative stress. The aim of this study was to determine the serum levels of thiol and IMA in patients with severe COVID-19 pneumonia to evaluate oxidative stress. This was a prospective, sectional cohort study conducted at a pandemics hospital between 01.01.2022 and 01.02.2022. A total of 153 patients who had been confirmed with severe COVID-19 pneumonia in the emergency unit were prospectively analyzed. The control group was formed by 50 healthy volunteers with similar age and no chronic disease history. Thiol and IMA levels were statistically compared both in the patient and the control groups, and within the patient groups (survived and non-survival). While 96 out of 153 patients had survived, 57 patients had non-survival. There was a statistically significant distinction between the survived and non-survival patients with regard to Thiol and IMA levels (p < 0.001). The thiol levels in the patient group were significantly lower compared to the control group, and the IMA levels were significantly higher (p < 0.001). The sensitivity, specificity and NPV were 70.2%, 86.5% and 83% when thiol cut-off value was ≤345.2 μmol/L (AUC: 0.886, p < 0.001). The sensitivity, specificity and NPV were 70.2%, 85.4% and 82.8% when the IMA cut-off was >302.9 ABSU (AUC: 0.875, p < 0.001). Our results demonstrate that thiol and IMA levels may be used as bioindicators for risk classification and mortality in patients with serious COVID-19 pneumonia.

Amaç: Karbonmonoksit (CO) zehirlenmesi dünya çapındaki ölümcül intihar veya kazara zehirlenmelerin en yaygın nedenlerinden birisidir. Tanısında spesifik bir biyobelirteç yoktur. Bu sebeple çalışmada CO zehirlenmesinde tam kan parametreleri’nin rolü araştırılmıştır.Gereç ve Yöntem: Çalışmada 1 Ocak 2014 – 1 Ocak 2016 tarihleri arasında acil serviste CO zehirlenmesi tanısı alan ve dışlama kriterlerini sağlayan toplam 442 hasta retrospektif olarak incelendi. Hasta grubunun demografik özellikleri ve tam kan sonuçlarına hastane kayıt sisteminden ulaşıldı. Kontrol grubu acil servise benzer şikâyetler ile başvuran 100 hastadan oluşturuldu. Her iki grubun lökosit (WBC), kırmızı hücre dağılım genişliği (RDW), platelet, lenfosit, nötrofil, nötrofil-lenfosit oranı (NLR) ve platelet-lenfosit oranı (PLR) değerleri istatistiksel olarak karşılaştırıldı. Bulgular: Hasta ve kontrol grubu yaş ve cinsiyet bakımından birbirleri ile benzerdi. Hasta grubunun WBC, RDW, Platelet, Lenfosit, Nötrofil, NLR ve PLR değerleri kontrol grubu ile kıyaslandığında anlamlı derece yüksek bulundu. Ancak hasta yatış süreleri ile Glaskow Koma Skalası (GKS), karboksihemoglobin (COHb), RDW, NLR ve PLR düzeyleri arasında anlamlı bir korelasyon bulunmamıştır.Sonuç: Çalışmamız RDW, NLR ve PLR düzeylerinin CO zehirlenmesi tanısını öngörmede kullanılabilir bir biyobelirteç olma potansiyeli olduğunu düşündürmüştür.

Amaç: Bu çalışmada, başvuru sırasında ölçülen hematolojik parametrelere dayalı indeklerin karbonmonoksit zehirlenmesinin (COZ) şiddetini tahmin etmedeki rolü araştırıldı. Gereç ve yöntem: 2018 ve 2022 tarihleri arasında bir Eğitim ve Araştırma hastanesi acil servisinde COZ tanısı konulan toplam 183 hasta retrospektif olarak incelendi. Hastaların klinik şiddetini belirlemek için COHb ve laktat düzeyleri kullanıldı. Hastalar hafif-orta karbon monoksit zehirlenmesi (hafif-orta COZ) ve ciddi karbon monoksit zehirlenmesi (ciddi COZ) olarak iki gruba ayrıldı. Sistemik immün inflamasyon indeksi (SII), sistemik inflamatuar cevap indeksi (SIRI) ve sistemik inflamasyon toplam indeksi (AISI), nötrofil/lenfosit oranı (NLR), platelet/lenfosit oranı (PLR) ve monosit/lenfosit oranı (MLR) bu iki hasta grubu arasında karşılaştırıldı. Bulgular: SII, SIRI, AISI, NLR, PLR ve MLR açısından her iki grup arasında önemli farklılık vardı (p1519.14 iken, sensitivite %67.9 ve spesifite %63.7 idi (AUC: 0.708, p4.955 iken, sensitivite %60 ve spesifite %78.5 olarak bulundu (AUC:0.746, p