In this work, we investigate the spectral, information-theoretic, and thermodynamic properties of a fractal Schrödinger system with position-dependent mass subject to an effective semiconductor-like confinement. We employ a fractal momentum operator and a Von Roos Hamiltonian with BenDaniel–Duke ordering to obtain exact analytical solutions for the energy spectrum and wave functions. The interplay between the fractal parameter $\alpha$, the effective lattice scale $l_0$, and the harmonic confinement strength $\omega$ is explored. We perform a comprehensive analysis of the Shannon entropy, Fisher information, and Fisher–Shannon complexity in both coordinate and momentum spaces. Our results demonstrate that these parameters directly control the localization–delocalization transition and the informational architecture of the quantum states, while satisfying the entropic and Fisher uncertainty relations. Furthermore, we derive the exact partition function and the corresponding thermodynamic properties (free energy, internal energy, entropy, and specific heat) of the system. The analytical framework presented offers valuable insights into the spectral, information-theoretic, and thermodynamic behavior of quantum systems in fractal semiconductor-like environments.