Hypoxia, as an important feature in tumor sites, greatly hinders the performance of photosensitizers, thus affecting the efficacy of photodynamic therapy (PDT). Therefore, designing and preparing new photosensitizer with high photosensitivity under hypoxic condition presents a great challenge that urgently needs to be solved. In this work, a new nano-MOF material using Mn(II) as the active center can catalytically decompose high concentrations of H₂O₂ in tumor cells to generate O₂, thereby improving the PDT efficacy in hypoxic tumors. The Mn-MOF also produces ¹O₂ under light irradiation, which finally induces cancer cell apoptosis. This work offers a new strategy for the design and discovery of effective photosensitizers for PDT.

A composite MOF-based sensor was designed and prepared for in situ fluorescence imaging of phosphate and pH, which provides a new way to effectively evaluate the diabetic complication-ketoacidosis in the early clinical stage.

A composite nanosensor based on Zr(IV)-MOFs and PNPP was developed, and was successfully applied for the in situ fluorescence imaging of phosphate and ALP levels in mice with parathyroid dysfunction. The current work provides new ideas for further development of the diagnosis of parathyroid diseases.

We describe a kind of Zr(iv)-based nano-MOF that is well suited for specific adsorption and selective fluorescence sensing of phosphate based on specific interactions between Zr(iv) and phosphate which provides a new approach for treatment of hyperphosphatemia.