Background: After renal trauma, surgical treatment is vital, but sometimes there may be loss of function due to fibrosis. This study aimed to evaluate the effect of autologous omentum flaps on injured renal tissues in a rat model. Methods: A total of 30 Wistar albino rats were included and randomly divided equally into a control group and four intervention groups. Iatrogenic renal injuries were repaired using a surgical technique (primary repair 1 group and primary repair 2 group) or transposition of the autologous omentum (omentum repair 1 group and omentum repair 2 group). Blood samples were taken preoperatively and on the 1st and 7th postoperative days in all groups and on the 18th postoperative day in the control and two intervention groups. All rats were sacrificed on the 7th or 18th day postoperatively, and their right kidneys were taken for histopathological evaluation. Results: The mean urea level significantly decreased from day 1 to day 7 and from day 1 to day 18 in the omentum repair 2 group (P = 0.005 and P = 0.004, respectively). There were no other significant changes in urea or creatinine levels within the intervention groups (P > 0.05). There was no significant correlation between the urea and creatinine levels and the histological scores (P > 0.05). The primary repair 1 and 2 groups had significantly higher median granulation and inflammation scores in the kidney specimen than the control and omentum repair groups (P < 0.05). The omentum repair 2 group had significantly lower median granulation and inflammation scores in the surrounding tissues than the primary repair 2 group (P < 0.05). The completion score for the healing process in the kidney specimen was significantly higher in the omentum repair groups than in the primary repair groups (P < 0.05). The omentum repair 2 group had significantly lower median granulation and inflammation scores in the surrounding tissues than the primary repair 2 group (P < 0.05). Granulation degree in the kidney specimen was strongly and positively correlated with the inflammation degree (r = 0.824, P < 0.001) and foreign body reaction in the kidney specimen (r = 0.872, P < 0.001) and a strong and negative correlation with the healing process completion score in the kidney (r = − 0.627, P = 0.001). Inflammation degree in the kidney specimen was strongly and positively correlated with the foreign body reaction in the kidney specimen (r = 0.731, P = 0.001) and strongly and negatively correlated with the healing process completion score in the kidney specimen (r = − 0.608, P = 0.002). Conclusion: Autologous omentum tissue for kidney injury repair attenuated inflammation and granulation. Additionally, the use of omental tissue to facilitate healing of kidney injury may theoretically lead to a more effective healing process and reduced fibrosis and tissue and function loss.

Purpose. To compare the effect of local and systemic injection of resveratrol (RSV) on open cutaneous wound healing. Materials and Methods. Open cutaneous wounds were created in adult Sprague–Dawley rats. Group 1 (n = 6) was given intraperitoneal RSV (0.5 mg/kg) once daily for 14 days. Group 2 (n = 6) was given local subcutaneous RSV (0.5 mg/kg) on the wound once daily for 14 days. Group 3 (n = 6) did not receive any pharmacologic agent. Biopsy specimens were obtained on postoperative days (PODs) 7, 14, and 21 and were examined histologically. Wound closure time was recorded. All rats were sacrificed on POD 30 for tensile strength analysis. Results. The histological scores for collagen deposition, chronic inflammation, and granulation were higher in the systemic and local RSV treatment groups than in the control group. Neovascularization scores significantly increased on PODs 14 and 21 in the local RSV treatment group compared with those in the systemic RSV and control groups. Systemic and local RSV administrations significantly enhanced wound healing and increased the tensile strength of the skin in rats. Conclusion. Local subcutaneous application of RSV may have a better therapeutic effect than the systemic application of RSV in terms of neovascularization to promote wound healing.

The study aimed to evaluate the efficiency of pomegranate (Punica granatum) seed oil in wound healing in excised rats. Sixteen female young Wistar Albino Rats weighing approximately 300 to 320 g were randomly divided into 2 groups as the treatment (=pomegranate seed oil group) and control groups in this experiment. Six different wounds 1 cm apart from the midline and each other were formed with a 6 mm punch biopsy instrument. Three wounds were left open (open wound group) whereas 3 wounds were sutured with 4/0 vicryl (closed wound group). Punica granatum seed oil treatment was administered topically to the treatment group, both to open and closed wounds, once a day for 14 days. Parameters for healing were evaluated. Histopathologic examination was performed for the investigation of inflammation, neovascularization, granulation, and fibroblast generation in addition to serologic (enzyme-linked immunosorbent assay) evaluation of rat malondialchehyche, rat glutathione peroxidase, and rat superoxide dismutase. PeriScan PIM 3 System Laser Doppler Blood Perfusion Imager was used for the calculation of blood perfusion. There was a statistically significant difference between inflammation and neovascularization levels and group type on the 14th day in open wounds(P < .05). On the 21st day, the granulation tissue level in the closed wound group was found to be higher in the pomegranate group (P = 0.000).The results showed that PSE oil is partially effective, although it is not effective in every parameter examined, in the treatment of excised wounds in rats and may be suitable for clinical treatment in humans but large controlled studies are needed.

Postoperative recovery process following laparoscopic cholecystectomy depends on many factors such as pain, fatigue and exhaustion. The objective of this study was to investigate whether the administration of dexamethasone, a glucocorticoid, has positive effects of postoperative patient comfort in patients who underwent laparoscopic cholecystectomy in our clinic. Patients who presented to the general surgery clinic of our hospital and scheduled for laparoscopic cholecystectomy due to cholelithiasis were included in this study. Patients in Group 1 received dexamethasone 90 minutes before the skin incision, while patients in Group 2 were given placebo (normal saline). Pain scores, presence of nausea and vomiting in the postoperative period were compared between the study and control groups. No statistically significant difference was observed between the groups in terms of incisional pain at rest and in motion and visceral pain at rest at postoperative 6th, 12th and 24th hours. Although there was a difference between the groups in terms of visceral pain in motion at the postoperative 12th and 24th hours, this was not statistically significant (p > 0.05). Although the need for additional analgesics and antiemetic drugs was lower in the study group compared to the control group, the difference between the groups was not statistically significant (p > 0.05). We can expect better results with the use of multimodal analgesic and anti-emetic combination instead of a single agent in studies to be performed about the prevention of postoperative pain, nausea and vomiting.

Introduction Laparoscopic surgery is a preferred method based on its many benefits. However, increasing abdominal pressure by CO2 insufflation during the implementation of this technique poses challenges. Aim To determine the degree of renal and liver injury that occurs in...

Aim: Diabetic foot infections are responsible from the 2/3 of the lower extremity amputations. The cost of diabetic foot ulcers is significantly high for the society. The aim of the present study was to select the best treatment module by performing the staging of the foot problems in diabetic patients, and decrease the rate of amputation which is a traumatic procedure that decrease the quality of life, and the mental health of the patient. Methods: Fourty-nine patients diagnosed as having diabetic foot who presented to the General Surgery Clinic of xxxxxxx were included in the study. Results: Thirty patients (61.2%) out of 49 were men, and 19 (38.8%) were mean. The mean age was 61.4 years (ranging, 39-80 years). All patients were diagnosed with type 2 diabetes. The evaluation in accordance with the Wagner classification showed that 4 (8.25%) patients were in Group 1, 19 (38,7%) were in Group 2, 13 patients (26.5%) were in Group 3, 9 (18.3%) were in Group 4, and 4 (8.5%) patients were in Group 5. No significant difference was detected between the Wagner classification, and amputations with the age, sex, fasting blood glucose, urea, creatinine levels. Conclusion: Diabetic foot infections are significant health problems which resulted with economic, and social burden because the complications are severe, and resulted with amputation and even with mortality. Therefore, the prevention of the occurrence of diabetic foot is important for the social and economic perspective.The identification of the risk factors of the disease, and educating the patients who are under risk are required. Amputation rates may be decreased with the initiation of the adequate treatment in proper time with the attentive approach of the physicians who are informed of the risk factors. The treatment of the diabetic foot infections may be accomplished, and the amputation rates may be decreased with a multidisciplinary approach.