1. Department of Molecular Cell Physiology, BioCentrum Amsterdam, Faculty of Biology, Vrije Universiteit, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands</br>2. Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Science Park 904 1098 XH Amsterdam, The Netherlands</br>3. Integrative Systems Biology, Manchester Interdisciplinary Biocentre (MIB), University of Manchester, 131 Princess Street, Manchester M1 7DN, UK