Aim: Acute extremity ischemia (AEI) is a disease in which the arterial perfusion of the limb is suddenly reduced, mostly due to a thromboembolic condition. There is a need for an urgent evaluation and intervention, most commonly surgical embolectomy. Surgically removed thrombus materials can provide information about the disease and its process. Method: Patients who underwent embolectomy for acute extremity ischemia between November 2021 and March 2022 were retrospectively analyzed, and the obtained embolectomy materials were histopathologically evaluated. Results: We included 32 cases of patients who underwent embolectomy surgery for AEI. The histopathological evaluation of the materials taken from these cases determined that the thrombus age was compatible with the first 48 hours. Malignant epithelial tumor cells were detected in one case. In addition, we assessed and showed that re-intervention was significantly higher in cases with a high fibrin score with chronic peripheral artery disease. Conclusion: We believe that the histopathological evaluation of the materials removed from patients who underwent embolectomy surgery for acute extremity ischemia can aid in diagnosis, guide treatment, and provide valuable prognostic information.