Patient-centered communication has emerged as a fundamental component of effective psychotherapy, significantly influencing the therapeutic process and outcomes. This narrative review examined 53 studies selected from PsycINFO, PubMed, and CINAHL databases published between 2010– 2024, focusing on empirical and theoretical work on patient-centered communication in psychotherapy. A significant portion of this review is dedicated to analyzing the effects of patient-centered communication on therapeutic outcomes. The evidence consistently demonstrates that this approach enhances the therapeutic alliance, improves treatment adherence and engagement, increases patient satisfaction, and leads to better overall mental health outcomes. The review also examines how patient-centered communication is applied across different therapeutic modalities, including cognitive-behavioral therapy, psychodynamic approaches, and group therapy settings. Cultural considerations in patient-centered communication are thoroughly explored, highlighting the importance of adapting communication styles for diverse populations and addressing language barriers and cultural differences. The review discusses the impact of culturally sensitive patient-centered communication on therapeutic outcomes for minority groups, emphasizing its potential to reduce disparities in mental health care. This narrative review also provides valuable insights for mental health professionals, researchers, and policymakers, underscoring the importance of patient-centered communication in advancing the field of psychotherapy and improving mental health care delivery.

The integration of artificial intelligence (AI) chatbots in adolescent mental health care represents a transformative shift in how digital interventions address psychological well-being among young populations. This comprehensive review synthesizes evidence examining the multifaceted impact of chatbot technology on adolescent mental health development. A systematic search was conducted across PubMed, PsycINFO, Web of Science, and Scopus databases using terms related to chatbots, conversational agents, adolescents, and mental health. Following PRISMA guidelines, 80 studies published between 2020 and 2025 were included after screening 1247 initial records and excluding duplicates and irrelevant articles. Through systematic analysis, we explore the complex relationships between chatbot usage and emotional health, social development, cognitive functioning, and behavioral patterns among adolescents aged 10– 24 years. The review reveals that chatbots demonstrate moderate effectiveness in reducing psychological distress (g = − 0.46 to − 0.10) and show promise in addressing barriers to mental health care access, particularly stigma-related concerns. However, emerging evidence also highlights potential risks including dependency, social withdrawal, and privacy concerns. The findings suggest that while chatbots offer valuable supplementary mental health support, careful consideration of ethical implications, cultural adaptations, and long-term developmental effects is essential for responsible implementation.

The diagnostic‐to‐treatment interval (DTI) of papillary thyroid carcinoma (PTC) has long been regarded as an inactive administrative period. We expected to find that DTI is a window of high metabolic activity where apolipoprotein dysregulation may lead to harm. A four‐phase integrated design was used. Phase 1 analysed transcriptomic and clinical data from TCGA‐THCA ( n = 209) to find DTI‐associated molecular alterations, and used a maximally selected rank statistic to set the optimal time window. Phase 2 verified the lipoprotein signature in three independent GEO cohorts (GSE29265/GSE33630/GSE60542). Phase 3 used XGBoost regression in conjunction with SHAP (SHapley Additive exPlanations) to explore gene–gene interactions and predictive structures. Phase 4 used two‐sample Mendelian randomization to determine whether genetically determined levels of the 233 metabolic biomarkers were associated with PTC. A 77‐day threshold optimally stratified postoperative complete response rates (91.5% for DTI ≤ 77 days vs. 79.0% for DTI > 77 days; p = 0.035). Differential expression analysis found 77 genes that were significantly associated with prolonged DTI, and the enriched pathways included PPAR signalling, fat digestion and apolipoprotein particle dynamics. Linear regression showed that longer DTI was associated with higher expression of APOA1 and APOC1. XGBoost–SHAP analysis showed that APOA1 and APOC1 were the top predictive features, and their interaction explained most of the non‐additive variance. Cross‐cohort validation showed that APOC1 and LPL were consistently upregulated and VLDLR was downregulated in all GEO datasets. Disease‐state predictive model building found that the LPL–APOC1 axis effectively distinguished tumour from normal tissue. In two‐sample MR analysis of 233 metabolic traits, genetically predicted VLDL and triglyceride‐rich lipoprotein traits showed a predominantly risk‐increasing direction of effect, and HDL cholesterol exhibited a protective effect, which was consistent with the transcriptomic results; however, no individual exposure remained significant after multiple testing correction in either outcome dataset, so the genetic analysis provided support for and extended the hypothesis rather than confirming it. Based on the above analysis, the pre‐operative period of PTC may be metabolically active rather than quiescent; however, this has not been confirmed in future studies. Dysregulation of the APOC1‐associated VLDL pathway is a reproducible cross‐cohort transcriptomic signature in PTC; although genetic analysis has been conducted directionally, strong causal evidence has not been obtained. Therefore, at the same time, we will shift from time‐limited to metabolically targeted preoperative risk assessment.

Women of reproductive age diagnosed with thyroid cancer face a distinctive psychological burden arising from the concurrent demands of disease management and primary caregiving, yet the mechanisms linking parenting stress to diminished well-being in this group remain poorly characterized. The present study applied a stress-buffering framework to examine whether psychological distress (anxiety and depressive symptoms) statistically mediated the association between parenting stress and well-being, and whether social support attenuates these pathways. We recruited a convenience sample of 400 consecutive eligible mothers between July and December 2025 at a tertiary cancer center in China. All were of reproductive age (18–49 years), had cytologically confirmed papillary thyroid carcinoma and at least one child aged ≤12 years, and completed the survey during their initial hospitalization, before surgery. Validated instruments assessed parenting stress, anxiety and depression, social support, and well-being; analyses included bivariate correlations, mediation, and moderated mediation models. Well-being correlated inversely with parenting stress (r = −0.447, p < 0.01) and anxiety and depression (r = −0.573, p < 0.01), and positively with social support (r = 0.515, p < 0.01). Psychological distress partially mediated the parenting stress–well-being association, with the indirect effect constituting 44.32% of the total effect (−0.210, 95% CI: −0.321 to −0.125). Parenting stress was positively associated with HADS scores (β = 0.322, p < 0.001), though this association was weaker at higher levels of social support (interaction β = −0.106, p = 0.006). Both parenting stress (β = −0.148, p = 0.001) and HADS scores (β = −0.367, p < 0.001) were independently associated with lower well-being, while social support moderated the parenting stress–well-being association (interaction β = 0.098, p = 0.003). In conclusion, parenting stress and psychological distress were jointly associated with diminished well-being in this population, but social support emerged as a modifiable protective correlate. Psychosocial interventions targeting stress reduction, emotional regulation, and support mobilization may thus hold particular promise for improving outcomes among young women with thyroid cancer.