Liver diseases represent an annual 2 million deaths worldwide [1]. Regarding mortality, cirrhosis is responsible for more than 1 million deaths worldwide, and liver cancer is responsible for almost 800,000 deaths/year [2, 3]. Furthermore, chronic liver disease leads to a high burden of disability and increased health care utilization, and its estimate is likely to be conservative and underestimated [4, 5].Specifically, in Portugal, liver disease burden is still a major health problem [6, 7]. Liver diseases are the 7th cause of death, with an increase in chronic liver disease, as seen in Europe globally, mainly due to alcohol consumption and increasing cases of obesity and diabetes mellitus [7, 8].During the past 3 decades, liver disease research has delivered significant breakthroughs. Promoting continuous cooperation between researchers, stimulating synergies between different research domains and boosting more high-quality research studies will lead to an improvement in management of many high-concern liver diseases more effectively. At present, most studies published in hepatology, in Portugal, are overwhelmingly single-centre and retrospective studies, with inherent biases. Furthermore, some areas of hepatology, such as alcohol-related liver disease have fewer studies supported by the pharmaceutical companies, although they represent a very heavy burden from a public health perspective [9].Therefore, multicentre and prospective research projects will allow for data that are more accurate and the development of precise strategies for liver diseases. In Portugal, these studies have been very difficult to implement. Although there is a national patient registry platform, Liver.pt, that was successfully used to perform a Portuguese cohort study in primary biliary cholangitis [10], it has never used to its full potential due to lack of common projects or capacity to coordinate them.It is in this context that the programme “Hepatologia em Rede” was born. This initiative from the Portuguese Association for the Study of the Liver (APEF) has a mission to improve national research in hepatology, in basic and clinical fields, support competitive research projects and thus, to amplify the Portuguese scientific position in the global hepatology research community.The objectives of the network hepatology programme are:1.To enhance and develop national research in the area of hepatology, in basic and clinical science;2.To homogenize at a national level the scientific quality of the works produced;3.To stimulate scientific dialogue and promote cooperation, as well as establishment of partnerships between different national and international hepatology research units, enhancing synergies and networking research projects;4.To enlarge the scientific production and to promote the realization of research works with increasing quality and relevance;5.To disseminate in the educational and scientific communities, nationally and internationally, the research carried out in hepatology;6.To support the training of young researchers;7.To encourage the submission of projects to specific national and international funding programmes, helping to create the conditions for their feasibility;8.To centralize reference contacts in foreign institutions for research and specific scientific training;9.To disseminate its work programme and its results.Since its establishment in 2021, “Hepatologia em Rede” has already received several collaborative national cohort projects. One example is a cross-sectional study on the prevalence of Wilson’s disease in Portugal. This study will be merged with data from the Spanish cohort of Wilson’s disease to produce robust data on an understudied and rare liver disease. Collaboration is an essential principle for scientific advancement, and for this reason, we strongly encourage all national centres which regularly treat liver patients to adhere to this programme.José Presa, Helena Cortez-Pinto, Carlos Ferreira, Dalila Costa, Filipe Nery, Susana Gomes Rodrigues, Joana Espírito Santo, Mariana Cardoso, Mariana Machado, Mário Jorge Silva, Rui Caetano Oliveira, Sílvia Vilarinho.Not applicable.The authors have no conflicts of interest to declare.No funding was provided.All authors contributed equally to this manuscript.All data generated or analysed during this study are included in this article. Further enquiries can be directed to the corresponding author.

Psychiatric manifestations of sporadic Creutzfeldt-Jakob disease simulate depressive disorder with psychotic symptoms