Background: Alcohol-related liver cirrhosis imposes a substantial clinical, functional, and psychosocial burden, significantly affecting patients' health-related quality of life (HRQoL). The aim of this study was to evaluate the relationship between disease severity, functional status, and HRQoL in patients with alcohol-related liver cirrhosis. Methods: This cross-sectional observational study included 144 adult patients with alcohol-related liver cirrhosis. Clinical, demographic, and laboratory data were collected, while HRQoL was assessed using the Short Form Liver Disease Quality of Life (SF-LDQOL) questionnaire. Disease severity was evaluated according to the Child–Pugh classification. Statistical analysis included descriptive statistics, Spearman correlation, the Kruskal–Wallis test, and multivariable logistic regression. Results: Most patients were classified as Child–Pugh A (75.7%), followed by Child–Pugh B (17.4%) and Child–Pugh C (6.9%). HRQoL was predominantly rated as fair or poor. Greater liver-related symptom burden and limitations in daily activities were significantly associated with poorer HRQoL. Patients with more advanced liver disease reported significantly lower HRQoL scores (p = 0.02), although impaired HRQoL was also observed in a substantial proportion of patients with compensated cirrhosis. In the multivariable analysis, social isolation remained independently associated with impaired overall HRQoL after adjustment for demographic and clinical characteristics. Conclusions: Health-related quality of life in patients with alcohol-related liver cirrhosis is influenced not only by disease severity but also by functional and psychosocial factors. Integrating patient-reported outcome measures with conventional clinical assessment may provide a more comprehensive evaluation of disease burden and support individualized multidisciplinary patient management.

Background: Liver cirrhosis imposes a substantial clinical, functional, and psychosocial burden, significantly affecting patients’ health-related quality of life (HRQoL). The aim of this study was to evaluate the relationship between disease severity, functional status, and HRQoL in patients with liver cirrhosis. Methods: This cross-sectional observational study included 144 adult patients with liver cirrhosis of diverse etiologies. Clinical, demographic, and laboratory data were collected, while HRQoL was assessed using the Short Form Liver Disease Quality of Life (SF-LDQOL) questionnaire. Disease severity was evaluated according to the Child–Pugh classification. Statistical analysis included descriptive statistics, Spearman correlation, the Kruskal–Wallis test, and Firth penalized multivariable logistic regression. Results: Most patients were classified as Child–Pugh A (75.7%), followed by Child–Pugh B (17.4%) and Child–Pugh C (6.9%). Overall quality of life was predominantly rated as fair or poor. Greater liver-related symptom burden and limitations in daily activities were significantly associated with poorer patient-reported quality-of-life outcomes. Overall quality of life differed significantly across Child–Pugh classes (p < 0.001), with poorer ratings in Child–Pugh B and C than in Child–Pugh A, although impaired quality of life was also observed among patients with compensated cirrhosis. In the forced-entry multivariable clinical model, Child–Pugh B was significantly associated with higher odds of impaired overall quality of life compared with Child–Pugh A (adjusted OR 33.32, 95% CI 1.90–582.94, p = 0.016), whereas age, sex, and etiology were not independently associated with the outcome. Conclusions: Health-related quality of life in patients with liver cirrhosis is associated with disease severity as well as with functional and psychosocial aspects of the patient-reported disease experience. Integrating patient-reported outcome measures with conventional clinical assessment may provide a more comprehensive evaluation of disease burden and support individualized multidisciplinary patient management.