In recent years, the increasing number of patients with spinal cord injuries, strokes, and lower limb disabilities has led to the gradual development of rehabilitation-assisted exoskeleton robots. A critical aspect of these robots is their ability to accurately sense human movement intentions to achieve smooth and natural control. This paper describes research carried out on predicting the motion angles of human lower limb joints. Based on the design of a signal acquisition system for physiological muscle signals and inertial measurement unit (IMU) data, a hybrid neural network prediction model (QRTCN-BiLSTM) and a single neural network prediction model (QRBiLSTM) were constructed using quantile regression, temporal convolution network (TCN) and bidirectional long short-term memory network (BiLSTM), respectively. At the same time, 7-channel surface electromyographic signals (sEMG) and 12-channel IMU data from hip and knee joints were collected and input into the QRBiLSTM and QRTCN-BiLSTM models to unfold the training and analyze the comparison. The results show that the QRTCN-BiLSTM model can more accurately infer human movement intention and provide a more reliable and accurate prediction tool for human–robot interaction research in rehabilitation robotics.