In the last two decades, there have been remarkable advances in the diagnosis and treatment of lung cancer, resulting in improved quality of life and increased survival. Despite that, lung cancer remains the leading cause of cancer death worldwide. The diagnosis, staging and management of lung cancer are dictated by guidelines that constitute a clear path for patients. However, the emotional and psychological challenges faced by patients with lung cancer may be overlooked and can affect the well-being of these patients. This can also negatively impact the patient adherence to therapy and the ultimate patient outcomes. In this article, we address the emotional and psychological manifestations in patients who are diagnosed with lung cancer. We highlight the importance of recognizing these symptoms early to ensure they are managed alongside the stressful and challenging lung cancer therapy, with the goal of improving the patients’ quality of life and general outcome.