Functional nanofibers have good porosity to exchange oxygen and appropriate surface hydrophilicity to promote cell adhesion and proliferation, which has attracted extensive attention in the medical research field in the treatment of skin repair diseases. Puerarin is a kind of isoflavones extracted from the roots of the leguminous plant pueraria lobata or kudzu vine. Because of its strong antioxidant, free radical scavenging and anti-tumor effects, puerarin has made some preliminary exploration in the research field of skin diseases in recent years. This paper summarizes the research progress of skin wound repair, puerarin treatment of skin diseases and nanotechnology in skin wound repair, with a view to providing new therapeutic ideas for the research and development of puerarin skin wound repair.

Cardiovascular diseases are common in aging populations and are closely associated with multiple factors. However, the cumulative effects of green-space ex

To address issues of pesticide resistance and environmental pollution in chemical control of ginseng black spot (caused by Alternaria panax) and unstable efficacy of traditional biological control, this study developed chitosan nanoparticles (CSNPs) co-loaded with antimicrobial berberine (BR) and immune-activating salicylic acid (SA), referred to as BR/SA@CSNPs based on the Traditional Chinese Medicine theory of "eliminating pathogens and reinforcing vital qi" (Qu Xie Fu Zheng), aiming to simultaneously suppress pathogens and activate plant resistance. BR/SA@CSNPs were prepared via optimized ionic cross-linking, with physicochemical properties and stability characterized. Efficacy was evaluated through in vitro antifungal activity (EC ₅₀ ) and ginseng antioxidant enzyme activity assays. Optimized BR/SA@CSNPs exhibited uniform particle size (162.4 ± 2.5 nm), good dispersity (PDI = 0.149 ± 0.041), environmental stability, and pH-responsive release. In vitro assays demonstrated significant pathogen inhibition (EC ₅₀ = 55.28 μg/mL), mycelial membrane disruption, and induction of oxidative damage. In vivo tests showed that BR/SA@CSNPs induced ginseng to activated antioxidant enzymes and suppressed lipid peroxidation. BR/SA@CSNPs successfully integrated the "eliminating pathogens and reinforcing vital qi" theory: BR directly suppressed pathogens (eliminating pathogens), SA activated SAR to enhance resistance (reinforcing vital qi), and the multifunctional CS carrier provided synergistic effects, offering a novel strategy for efficient and green nano-pesticide control of ginseng black spot.

Introduction: Telomere shortening is a hallmark of aging and age-related diseases, yet evidence linking it to pulmonary diseases remains limited. Methods: We included 4,994 participants aged ≥50 years from the 2008 HRS wave with available telomere measurement data. Pulmonary disease status was defined using the 2008 HRS self-reported physician-diagnosed chronic lung disease item, which includes conditions such as chronic bronchitis or emphysema and excludes asthma. Multivariable logistic regression models were used to examine the association between telomere length and the odds of prevalent chronic lung disease. Stratified analyses, restricted cubic spline (RCS) regression, and sensitivity analyses were conducted. Results: Each interquartile range (IQR) increase in telomere length was associated with a 14.3% lower odds of prevalent pulmonary disease (adjusted OR = 0.857, 95% CI: 0.774–0.945, P = 0.002). Participants in the longest telomere quartile (Q4) exhibited 38.0% lower odds compared to those in the shortest quartile (Q1). However, after excluding participants exposed to parental smoking during childhood, the association was attenuated and was no longer statistically significant (OR = 0.901, 95% CI: 0.736–1.091, P = 0.297). Discussion: Telomere shortening may be biologically related to pulmonary disease-related processes via cellular senescence and chronic inflammation. Shorter telomere length was associated with higher odds of prevalent self-reported chronic lung disease in the full sample; however, this association became non-significant after excluding participants exposed to parental smoking during childhood, indicating that the full-sample association should not be interpreted as independent of early-life tobacco exposure. Longitudinal studies are needed to clarify temporality.