Yashapl S. Chhonker’s research focuses on the preclinical pharmacokinetics of novel small molecules (bio-availability, dose proportionality, gender variation, inter-species scaling). His research helps to identify small molecules to move forward in drug development based on metabolic stability, metabolite dentification, formation of reactive metabolites, and drug transport and permeability across biological barriers. Yashapl S. Chhonker evaluates metabolic pathways utilizing metabolomics to help to guide drug sequencing in a variety of disease states. In addition, he applies mathematical modeling of pharmacokinetic and pharmacodynamic data to evaluate drug concentration and response. These mathematical models are used for the simulation of drug dosing to optimize dose and dosage regimens.