Dr. Ritchie is focused on studying two major dentin noncollagenous proteins -- dentin sialoprotein (DSP) and physophporyn (PP) -- whose appearance is coupled to the conversion of uncalcified predentin to calcified dentin. The work encompassess following four DSP-PP related areas: (1) regulation and function of rat dentin sialoprotein and phosphophoryn, (2) tissue engineering to test whether DSP and PP proteins can serve as biomimetic molecules in promoting dentin regeneration, (3) DSP-PP gene expression in non-mineralized tissues such as bone, kidney and salivary glands during organogenesis, and (4) DSP-PP precursor processing studies.
Short Biography
Dr. Ritchie is focused on studying two major dentin noncollagenous proteins -- dentin sialoprotein (DSP) and physophporyn (PP) -- whose appearance is coupled to the conversion of uncalcified predentin to calcified dentin. The work encompassess following four DSP-PP related areas: (1) regulation and function of rat dentin sialoprotein and phosphophoryn, (2) tissue engineering to test whether DSP and PP proteins can serve as biomimetic molecules in promoting dentin regeneration, (3) DSP-PP gene expression in non-mineralized tissues such as bone, kidney and salivary glands during organogenesis, and (4) DSP-PP precursor processing studies.
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