Objective: Spontaneous abortion is the most common complication of early pregnancy, affecting up to 20% of recognized pregnancies. Kisspeptin is predominantly released by placental syncytiotrophoblasts, and regulates their placental invasion into the uterine matrices. We aimed to establish an association of serum kisspeptin levels with pregnancy outcomes during the early gestational stage of the first trimester. Method: In this prospective study, 90 pregnant women in their 7 to 8 6/7 gestational weeks were classified into three groups: (i) The control group, consisting of healthy pregnant women (n=30), (ii) the threatened abortion group (n=30), and (iii) the spontaneous abortion group (n=30). The maternal serum samples were analyzed for complete blood count parameters and kisspeptin levels. Results: There was no statistical difference regarding body mass index (BMI) and gestational age (p=0.370). Regarding detailed obstetric notations, including gravida, parity, abortion, and living children, socioeconomic levels, and employment rates, all study groups were comparable (p>0.05, for all). No significant association was found regarding the biochemical parameters of complete blood count, including neutrophil, lymphocyte, and platelet concentrations, as well as neutrophil-to-lymphocyte ratios (NLR) and platelet-to-lymphocyte ratios (PLR) (p>0.05, for all). The median serum kisspeptin levels of the study groups did not differ between the groups (p=0.153). Correlation analysis revealed no significant relationship between serum kisspeptin levels and other study parameters in any study groups (p>0.05, for all) Conclusions: We found no statistically significant relationship between serum kisspeptin concentrations and pregnancy outcomes in the early gestational stage of the first trimester, and serum kisspeptin concentrations did not seem to be a reliable marker to distinguish abortion status from viable pregnancy

This study aimed to evaluate and compare perinatal outcomes, neonatal intensive care unit (NICU) admission rates, and neonatal immunization rates between Syrian immigrant and Turkish citizen pregnant women. A retrospective cohort analysis was conducted using hospital records of Syrian and Turkish citizen pregnant women who received care at a tertiary referral center between June 2020 and June 2025. Demographic characteristics, perinatal outcomes, and neonatal vaccination rates were collected and analyzed. A total of 10,560 pregnant women were included in the study. The participants were divided into two groups based on nationality: 10,407 were of Turkish origin and 158 were of Syrian origin. The mean age of all participants was 31.48 ± 5.54 years. The mean gestational age at delivery was 38 weeks, and the average birth weight was 3191.92 ± 591.11 g. The mean age of Turkish pregnant women was 31.48 ± 5.52 years, while the mean age of Syrian pregnant women was 31.67 ± 6.47 years. The mean gestational age at delivery was 38 weeks for Turkish women and 39 weeks for Syrian women. The mean birth weight of newborns born to Turkish women was 3190 ± 591.25 g, whereas the mean birth weight of newborns born to Syrian women was 3267 ± 581.64 g. The mean duration of hospital stay post-delivery was 40.16 ± 10.77 h. The incidence of multiple pregnancies was 1.4%. Cesarean section was the most common mode of delivery, with a rate of 67%. The mean length of hospital stay for Turkish pregnant women was 40.19 ± 10.76 h, whereas it was 37.92 ± 11.39 h for Syrian pregnant women. The rate of multiple pregnancies was 1.5% among Turkish women and 1.3% among Syrian women. The overall cesarean section rate was 67.2% in Turkish women and 56.3% in Syrian women. Among newborns born to Turkish mothers, the rate of hepatitis B vaccination was 86.3%, and the rate of vitamin K administration was 89.3%. In newborns born to Syrian mothers, the hepatitis B vaccination rate was 82.9%, and the rate of vitamin K administration was 88%. Hepatitis B vaccine was administered to 86% of all newborns, and vitamin K injection was given to 89% of them. Secondary-level NICU admission was observed more often among neonates of Syrian immigrant mothers (38.6%) compared to Turkish citizens (32.8%). Perinatal outcomes were comparable between Syrian immigrant and Turkish citizen pregnant women. Although neonates born to immigrant mothers did not require advanced intensive care more frequently, the need for secondary-level NICU admission was higher.

Objective: This study aimed to evaluate the diagnostic utility of the albumin/lymphocyte ratio (ALR) and mean platelet volume/lymphocyte ratio (MPVLR) novel inflammatory markers not previously studied in hyperemesis gravidarum (HG) as potential biomarkers in patients diagnosed with HG. Patients and Methods: A total of 68 first‐trimester pregnant women with clinically diagnosed HG and 78 healthy pregnant controls were included. Systemic inflammatory markers including neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), albumin/fibrinogen ratio (AFR), fibrinogen/lymphocyte ratio (FLR), magnesium/lymphocyte ratio (MgLR), ALR, MPVLR, and systemic immune‐inflammation index (SII) were calculated and compared between the two groups. Results: Lymphocyte counts and ketonuria levels were significantly higher in the HG group. Conversely, ALR and MPVLR values were significantly lower in the HG group. MPVLR was identified as a potential diagnostic marker for HG with a cutoff value of 4.569, yielding a sensitivity of 54.4% and specificity of 44.9%. ALR demonstrated a cutoff value of 22.853 with a sensitivity of 61.8% and specificity of 38.5%. Conclusions: In contrast to the previous literature, PLR and NLR levels were not elevated in HG patients. However, ALR and MPVLR previously unexamined in this population were significantly lower, suggesting a potential role in HG pathophysiology. The findings underscore the complexity and dynamic nature of inflammatory responses in HG, warranting further investigation.

Bu çalışma ile annede saptanan enfeksiyonların, çocuğa geçiş riskinin değerlendirilmesi, ülkemizde tam olarak durumu bilinmeyen konjenital toksoplazmoz hakkında temel bir veri sağlanması amacıyla moleküler ve serolojik yöntemlerin bir arada kullanılması amaçlanmıştır. XX Üniversitesi XX Eğitim ve Araştırma Hastanesi’nde normal vajinal yolla veya sezaryenle doğum yapan 18-45 yaş arası 76 gebenin venöz kan örneği ile plasentanın maternal yüzünden doku örneği ve umblikal korddan kan örneği alındı. Gebeler rutin tetkikler sırasında istenilen ELISA anti- Toxoplasma gondii IgM/IgG sonuçlarına göre hasta ve kontrol olarak iki gruba ayrıldı. Hastane Bilgi Sisteminden gebelerin yaş, gebelik sayısı, doğum sayısı ile bebeğin cinsiyeti doğum ağırlığı, apgar skoru bilgileri toplandı. Anne venöz kan örneği ve umblikal korddan alınan kan örneklerinden elde edilen serumlar T. gondii spesifik antikorlarının tespiti ve konfirmasyonu için altın standart olan Sabin-Feldman boya testi ile yeniden değerlendirildi. Plasentada T. gondii DNA varlığını saptamak için nested-PCR yönteminden yararlanıldı. Anti-T. gondii IgM/IgG değerleri pozitif olan 25 gebenin sadece 4 (%16)’ünde anti-T. gondii IgM pozitifliği vardı. 20 (%80) gebede anti-T. gondii IgG, 1 (%4) gebede ise anti-T. gondii IgM ve anti-T. gondii IgG birlikte pozitifti. Hasta grubundaki 25 gebenin yaş ortalaması 30,3 iken kontrol grubundaki 51 gebenin ise 28,3 idi. Hasta ve kontrol grubu için değerler sırasıyla aşağıdaki gibi bulundu: Gebelik hafta ortalaması: 39,1’e 38,8; Multigrad: %80’e %73; Erkek bebek oranı: %60’a %44; Doğum ağırlığı ortalaması: 3211,4 gr’a 3236,8 gr; Apgar skoru ortalaması 7,9’a 7,9. Sonuçlar arasında istatistiksel olarak anlamlı bir fark bulunamadı. Anti-T. gondii IgM/IgG negatif olan 51 örneğin anne venöz ve umblikal kord serumlarının hiçbirisinde SFDT ile (%0) pozitiflik saptanmadı. Anti-T. gondii IgM/IgG pozitif 25 örneğin 13 (%52)’ünün hem anne hem de umblikal kord serumları SFDT ile negatif olarak değerlendirildi. SFDT’ye göre ELISA IgG+IgM duyarlılığı: %100; özgüllüğü: %79,7, negatif prediktif değeri: %100, pozitif prediktif değeri: %48 bulundu. İncelenen 76 (%0) plasenta örneğinin hiçbirisinde T. gondii’ye ait DNA bantları gözlenmedi. Çalışmamızdaki maternal kanların yarısından fazlası referans SFDT ile pozitif olarak teyit edilememiştir. Plasentaların hiçbirisinde T. gondii DNA’sı saptanamamışsa da kısıtlı sayıdaki örnekle yürütülen bu pilot araştırma kapsamında XX ilinde anneden bebeğe toksoplazma geçiş riskinin düşük olduğunun söylenmesi mümkün değildir. Yöntemin oturtulması açısından büyük deneyim kazandıran bu çalışmanın özellikle anti-T. gondii IgM pozitif örnek sayısı arttırılarak ve farklı bölgelerden daha çok örnek toplanarak tekrarlanması planlanmaktadır.

Antimuscarinic therapy is a first-line pharmacological treatment for overactive bladder (OAB), but individual response is highly variable. This study aimed

Access to quality and reliable information sources during pregnancy, which is a special period, is important for both maternal and fetal health. The reliability and quality of the information obtained from video platforms such as YouTube are important. This study was designed to evaluate the quality and reliability of YouTube videos on thyroid disorders which are common during pregnancy. A total of 248 videos found on YouTube with the keywords 'thyroid disorders during pregnancy,' 'pregnancy and thyroid disorders' and 'pregnancy and thyroid gland' were recorded. After applying criteria, the remaining 68 videos were evaluated. General characteristics of the videos, modified DISCERN scoring and Global Quality Scale (GQS) scoring were performed. The videos were divided into two groups based on their sources: Obstetricians and Gynecologists, and Internal Medicine/Endocrinology physicians. A 10-parameter scoring system including necessary information about thyroid disease during pregnancy was used. As a result of the analysis of 68 videos evaluated in the study; it was observed that the information on diagnosis and treatment in the videos prepared by Internal Medicine/Endocrinology physicians regarding of thyroid diseases in pregnancy was better than the videos prepared by Obstetrics and Gynecology physicians (p<0.05). When videos were evaluated in terms of quality and reliability, both groups were found to have similar quality and reliability. When all videos were analyzed, 41% were classified of high quality, 41% were of medium quality, and 18% were of low quality. The quality and reliability of YouTube videos on thyroid diseases during pregnancy were found to be high. However, the video content needs to be more comprehensive.