Telework has expanded rapidly, and understanding the behaviors employees enact under it has become correspondingly important. This study develops an integrative conceptual framework specifying the multidimensional nature of telework behavior. A systematic literature review following PRISMA identified 114 review articles, which were analyzed using constructivist grounded theory. Six behavioral dimensions were identified, covering performance, communication, environmental, task, policy, and well-being conduct. Antecedents were grouped into individual factors, job characteristics, organizational norms, technological factors, and work environment factors. Outcomes were grouped into job satisfaction, productivity, turnover, health and well-being, work–life balance, and social isolation. Three contextual moderators were identified, namely telework modality, telework preference, and cultural and national context. Fourteen propositions link these categories and are advanced as testable claims rather than established findings, since they are derived from published review evidence and have not been empirically tested. The framework proposes telework behavior as the construct through which the conditions of remote work are translated into employee and organizational outcomes, and it specifies a content domain from which measures of the construct can be developed. It also indicates where organizations can direct policy, training, and intervention.