The goal of the study is to compare the most popular protocols available in IoT (Internet of Things) nodes and how they perform across multiple samples in controlled conditions. The focus is on local telemetry transmission, in which the ESP32-C6 and ESP32-S3 boards communicate with two other devices—a router and a laptop—over the 2.4 GHz band. For the experiment, three standard nominal transmission sizes of 16, 64, and 256 bytes were pre-set. Each size was trialed for 30 samples for each protocol. All transmissions achieved a 100% success rate and were received by the end device. Both latency and success rate were used as the main performance indicators. The end results were that CoAP had the lowest mean latency of 47.0 ms, followed by MQTT with 63.0 ms and HTTP with a mean overall latency of 1419.0 ms. A comparative test with the ESP32-S3 revealed that while the overall protocol ranking remained identical, the gap eventually narrowed. The more powerful ESP32-S3 processed HTTP significantly faster (mean latency of 449.0 ms) but yielded slower latencies for the lightweight CoAP and MQTT protocols compared to the C6. The results indicate an order of magnitude faster performance of CoAP and MQTT than HTTP in the test setup. The study offers a simple and reproducible setup and benchmarking, allowing it to serve as a practical reference point when selecting the right protocol for a given use case.