Dr. Bin Wu
Ocean College, Zhejiang University, Hangzhou 310058, China
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Academic Career Length
17Years (2010-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications1 August 2015 in Fish & Shellfish Immunology
Journal Article
NANajeeb Akhter
Najeeb AkhterBin WuAMAamir Mahmood Memon
Aamir Mahmood MemonMMMuhammad Mohsin
Muhammad Mohsin1 July 2021 in Fish & Shellfish Immunology
Journal Article
UBUsman Dawood Butt
Usman Dawood ButtNLNa Lin
Na Lin
NANajeeb Akhter
Najeeb Akhter
TSTooba Siddiqui
Tooba SiddiquiSLSihui Li
Sihui Li
Bin WuJournal Article
SSsayed Asmat Ali shah
sayed Asmat Ali shahNANajeeb Akhter
Najeeb AkhterBABibi Nazia Auckloo
Bibi Nazia AucklooIKISHRAT KHAN
ISHRAT KHANYLYanbin Lu
Yanbin Lu
Yue-Wei Guo +2
Nowadays, various drugs on the market are becoming more and more resistant to numerous diseases, thus declining their efficacy for treatment purposes in human beings. Antibiotic resistance is one among the top listed threat around the world which eventually urged the discovery of new potent drugs followed by an increase in the number of deaths caused by cancer due to chemotherapy resistance as well. Accordingly, marine cyanobacteria, being the oldest prokaryotic microorganisms belonging to a monophyletic group, have proven themselves as being able to generate pharmaceutically important natural products. They have long been known to produce distinct and structurally complex secondary metabolites including peptides, polyketides, alkaloids, lipids, and terpenes with potent biological properties and applications. As such, this review will focus on recently published novel compounds isolated from marine cyanobacteria along with their potential bioactivities such as antibacterial, antifungal, anticancer, anti-tuberculosis, immunosuppressive and anti-inflammatory capacities. Moreover, various structural classes, as well as their technological uses will also be discussed.
Journal Article
Bin WuJWJutta Wiese
Jutta WieseALAntje Labes
Antje LabesAKAnnemarie Kramer
Annemarie KramerRSRolf Schmaljohann
Rolf SchmaljohannJIJohannes Imhoff
Johannes ImhoffAn unusual polyketide with a new carbon skeleton, lindgomycin (1), and the recently described ascosetin (2) were extracted from mycelia and culture broth of different Lindgomycetaceae strains, which were isolated from a sponge of the Kiel Fjord in the Baltic Sea (Germany) and from the Antarctic. Their structures were established by spectroscopic means. In the new polyketide, two distinct domains, a bicyclic hydrocarbon and a tetramic acid, are connected by a bridging carbonyl. The tetramic acid substructure of compound 1 was proved to possess a unique 5-benzylpyrrolidine-2,4-dione unit. The combination of 5-benzylpyrrolidine-2,4-dione of compound 1 in its tetramic acid half and 3-methylbut-3-enoic acid pendant in its decalin half allow the assignment of a new carbon skeleton. The new compound 1 and ascosetin showed antibiotic activities with IC50 value of 5.1 (±0.2) µM and 3.2 (±0.4) μM, respectively, against methicillin-resistant Staphylococcus aureus.
Journal Article
Bin WuVOVanessa Oesker
Vanessa OeskerJWJutta Wiese
Jutta WieseRSRolf Schmaljohann
Rolf SchmaljohannJIJohannes Imhoff
Johannes ImhoffTwo unusual pyridones, trichodin A (1) and trichodin B (2), together with the known compound, pyridoxatin (3), were extracted from mycelia and culture broth of the marine fungus, Trichoderma sp. strain MF106 isolated from the Greenland Seas. The structures of the new compounds were characterized as an intramolecular cyclization of a pyridine basic backbone with a phenyl group. The structure and relative configuration of the new compounds were established by spectroscopic means. The new compound 1 and the known compound 3 showed antibiotic activities against the clinically relevant microorganism, Staphylococcus epidermidis, with IC50 values of 24 μM and 4 μM, respectively.
Journal Article
Bin WuVOVanessa Oesker
Vanessa OeskerJWJutta Wiese
Jutta WieseSMSusann Malien
Susann MalienRSRolf Schmaljohann
Rolf SchmaljohannJIJohannes Imhoff
Johannes ImhoffA novel spirocyclic drimane coupled by two drimane fragment building blocks 2 and a new drimane 1 were identified in mycelia and culture broth of Stachybotrys sp. MF347. Their structures were established by spectroscopic means. This is the first example of spirocyclic drimane coupled by a spirodihydrobenzofuranlactam unit and a spirodihydroisobenzofuran unit; and the connecting position being N-C instead of an N and N connecting unit. Strain MF347 produced also the known spirocyclic drimanes stachybocin A (12) and stachybocin B (11) featured by two sesquiterpene-spirobenzofuran structural units connected by a lysine residue; the known spirocyclic drimanes chartarlactam O (5); chartarlactam K (6); F1839A (7); stachybotrylactam (8); stachybotramide (9); and 2α-acetoxystachybotrylactam acetate (10); as well as ilicicolin B (13), a known sesquiterpene. The relative configuration of two known spirobenzofuranlactams (3 and 4) was determined. All compounds were subjected to biological activity tests. The spirocyclic drimane 2, 11, and 12, as well as the sesquiterpene 13, exhibited antibacterial activity against the clinically relevant methicillin-resistant Staphylococcus aureus (MRSA).
About Me
Bin Wu was born in Zhejiang (China). He obtained his Ph.D. in the field of organic chemistry in 2007 at the Department of Chemistry, Zhejiang University (Hangzhou, China). Subsequently, he was relocated to the Pharmaceutical College, Zhejiang University, where he pursued research in the field of Medicinal Chemistry as a post-doc research fellow, assistant professor and associate professor. In 2011, he moved his lab to the Ocean College, Zhejiang University, where he was promoted as a full professor. He is now engaged in a range of projects related to the discovery of new natural products from marine environments. Projects vary from stress-driven discovery of bioactive natural products from extreme marine environment hydrothermal vents and the evaluation of microbial diversity of unique marine habitats to the development of new ways of culture and molecular methods to access cryptic natural product biosynthetic pathways, the development of new approaches to purify and characterize polysaccharides, and the characterization of toxin to the research of metabolomics.
Five most representative publications in last five years
1. Li, XY; Awakawa, T; Mori, T; Ling, MQ; Hu, D; Wu, B; Abe, I. Heterodimeric Non-heme Iron Enzymes in Fungal Meroterpenoid Biosynthesis. The Journal of the American Chemical Society (JACS). 2021, 143(50): 21425–21432