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Eutectic solvents (ESs) are a relatively new class of solvents that have been arousing a lot of attention due to their easy preparation and great tunability of their thermophysical properties, which has been granting their application in a wide range of areas. The aim of this work is to present a new ES based on the mixture of an organic sodium salt, sodium hexanoate and dodecanoate, and a long alkyl chain carboxylic acid, octanoic, nonanoic, and decanoic acids, and to infer about the effect of introducing a sodium atom. The solid–liquid phase diagrams of these new sodium salt-based ES were determined to evaluate the liquid window where they can be confidently used as solvents. Other important properties of solvents have also been studied, and in particular, density and viscosity, at atmospheric pressure and in the temperature range between 293.15 and 353.15 K, were measured. In addition, the polarity of these new sodium salt-based deep eutectic solvents (DESs) was evaluated in terms of the Kamlet–Taft α, β, and π* and ETN parameters. The obtained results were compared with those of other commonly used hydrophilic and hydrophobic DESs and conclusions were taken.
Bruna Soares; Francisco Cunha; Inês Silva; Catarina Florindo; Luis C. Branco; Isabel M. Marrucho. Sodium Hexanoate and Dodecanoate Salt-Based Eutectic Solvents: Density, Viscosity, and Kamlet–Taft Parameters. Journal of Chemical & Engineering Data 2021, 1 .
AMA StyleBruna Soares, Francisco Cunha, Inês Silva, Catarina Florindo, Luis C. Branco, Isabel M. Marrucho. Sodium Hexanoate and Dodecanoate Salt-Based Eutectic Solvents: Density, Viscosity, and Kamlet–Taft Parameters. Journal of Chemical & Engineering Data. 2021; ():1.
Chicago/Turabian StyleBruna Soares; Francisco Cunha; Inês Silva; Catarina Florindo; Luis C. Branco; Isabel M. Marrucho. 2021. "Sodium Hexanoate and Dodecanoate Salt-Based Eutectic Solvents: Density, Viscosity, and Kamlet–Taft Parameters." Journal of Chemical & Engineering Data , no. : 1.
Antiseptics and disinfectants are extensively used for a variety of topical and hard-surface applications. A wide variety of biocides as active chemical agents is found in these products, including alcohols, phenols, iodine, and chlorine. Many of these active agents demonstrate broad-spectrum antimicrobial activity; however, the mode of action of these agents is not well-documented. This review is focused on several examples of ionic systems based on ionic surfactants and ionic liquids as well as nanomaterials and nanoparticles acting as antiseptics and disinfectants for surfaces. It is important to note that many of these biocides may be used singly or in combination in a variety of products, which vary considerably in activity against microorganisms. Antimicrobial activity can be influenced by several factors such as formulation effects, presence of an organic load, synergy, temperature, dilution, and test method. The most promissory compounds based on ionic systems and nanomaterials published in mainly the last decade is chronologically reported in this review.
Francisco Faísca; Luis Filipe; Zeljko Petrovski; Miguel Santos; Sandra Gago; Luís Branco. Ionic Systems and Nanomaterials as Antiseptic and Disinfectant Agents for Surface Applications: A Review. Surfaces 2021, 4, 169 -190.
AMA StyleFrancisco Faísca, Luis Filipe, Zeljko Petrovski, Miguel Santos, Sandra Gago, Luís Branco. Ionic Systems and Nanomaterials as Antiseptic and Disinfectant Agents for Surface Applications: A Review. Surfaces. 2021; 4 (2):169-190.
Chicago/Turabian StyleFrancisco Faísca; Luis Filipe; Zeljko Petrovski; Miguel Santos; Sandra Gago; Luís Branco. 2021. "Ionic Systems and Nanomaterials as Antiseptic and Disinfectant Agents for Surface Applications: A Review." Surfaces 4, no. 2: 169-190.
Several organic salts based on the combination of two different choline derivative cations and MnCl3−, GdCl4− and TbCl4− as anions were immobilized in mesoporous silica nanoparticles (MSNs) by a two-step synthetic method.
Andreia Forte; Sandra Gago; Manuela Lopes Ribeiro Carrott; Peter J. M. Carrott; Celso Alves; Fernando Teodoro; Rui Pedrosa; Isabel M. Marrucho; Luis C. Branco. Mesoporous silica nanoparticles with manganese and lanthanide salts: synthesis, characterization and cytotoxicity studies. Dalton Transactions 2021, 50, 8588 -8599.
AMA StyleAndreia Forte, Sandra Gago, Manuela Lopes Ribeiro Carrott, Peter J. M. Carrott, Celso Alves, Fernando Teodoro, Rui Pedrosa, Isabel M. Marrucho, Luis C. Branco. Mesoporous silica nanoparticles with manganese and lanthanide salts: synthesis, characterization and cytotoxicity studies. Dalton Transactions. 2021; 50 (24):8588-8599.
Chicago/Turabian StyleAndreia Forte; Sandra Gago; Manuela Lopes Ribeiro Carrott; Peter J. M. Carrott; Celso Alves; Fernando Teodoro; Rui Pedrosa; Isabel M. Marrucho; Luis C. Branco. 2021. "Mesoporous silica nanoparticles with manganese and lanthanide salts: synthesis, characterization and cytotoxicity studies." Dalton Transactions 50, no. 24: 8588-8599.
Antifungal susceptibility assays and molecular dynamics simulation studies reveal a novel cetylpyridinium amphotericin B ionic liquid formulation with dual functionality: antifungal and antibacterial activities.
Diego O. Hartmann; Karina Shimizu; Maika Rothkegel; Marija Petkovic; Ricardo Ferraz; Željko Petrovski; Luís C. Branco; José N. Canongia Lopes; Cristina Silva Pereira. Tailoring amphotericin B as an ionic liquid: an upfront strategy to potentiate the biological activity of antifungal drugs. RSC Advances 2021, 11, 14441 -14452.
AMA StyleDiego O. Hartmann, Karina Shimizu, Maika Rothkegel, Marija Petkovic, Ricardo Ferraz, Željko Petrovski, Luís C. Branco, José N. Canongia Lopes, Cristina Silva Pereira. Tailoring amphotericin B as an ionic liquid: an upfront strategy to potentiate the biological activity of antifungal drugs. RSC Advances. 2021; 11 (24):14441-14452.
Chicago/Turabian StyleDiego O. Hartmann; Karina Shimizu; Maika Rothkegel; Marija Petkovic; Ricardo Ferraz; Željko Petrovski; Luís C. Branco; José N. Canongia Lopes; Cristina Silva Pereira. 2021. "Tailoring amphotericin B as an ionic liquid: an upfront strategy to potentiate the biological activity of antifungal drugs." RSC Advances 11, no. 24: 14441-14452.
Different alkali deep eutectic solvents (DES), such as LiI:nEG, NaI:nEG, and KI:nEG, have been tested as electrolytes for dye sensitized solar cells (DSSCs). These DSSCs were prepared using pure DES or, alternatively, DES combined with different amounts of iodine (I2). The most important parameters, such as open circuit voltage (VOC), short circuit current density (JSC), fill factor (FF), and the overall conversion efficiency (η), were evaluated. Some DES seem to be promising candidates for DSSC applications, since they present higher VOC (up to 140 mV), similar FF values but less current density values, when compared with a reference electrolyte in the same experimental conditions. Additionally, electrochemical impedance spectroscopy (EIS) has been performed to elucidate the charge transfer and transport processes that occur in DSSCs. The values of different resistance (Ω·cm2) phenomena and recombination/relaxation time (s) for each process have been calculated. The best-performance was obtained for DES-based electrolyte, KI:EG (containing 0.5 mol% I2) showing an efficiency of 2.3%. The efficiency of this DES-based electrolyte is comparable to other literature systems, but the device stability is higher (only after seven months the performance of the device drop to 60%).
Hugo Cruz; Ana Pinto; Noémi Jordão; Luísa Neves; Luís Branco. Alkali Iodide Deep Eutectic Solvents as Alternative Electrolytes for Dye Sensitized Solar Cells. Sustainable Chemistry 2021, 2, 222 -236.
AMA StyleHugo Cruz, Ana Pinto, Noémi Jordão, Luísa Neves, Luís Branco. Alkali Iodide Deep Eutectic Solvents as Alternative Electrolytes for Dye Sensitized Solar Cells. Sustainable Chemistry. 2021; 2 (2):222-236.
Chicago/Turabian StyleHugo Cruz; Ana Pinto; Noémi Jordão; Luísa Neves; Luís Branco. 2021. "Alkali Iodide Deep Eutectic Solvents as Alternative Electrolytes for Dye Sensitized Solar Cells." Sustainable Chemistry 2, no. 2: 222-236.
The growing concern with environmental issues and the rapid development of new engines accentuated the need for more efficient and green lubricants. Ionic liquids (ILs) have emerged as promising alternatives to the conventional lubricants due to their interesting properties. However, the manufacturing costs of ILs are usually high, making their application as neat lubricants impracticable. A viable solution to overcome this drawback is the application of ILs as additives to commonly used base oils. Another very attractive alternative is related to the deep eutectic solvents (DES), which have similar properties to ILs but are much cheaper and simple to prepare. This paper aims at reviewing the most relevant research done in the field of lubrication using IL additives and DES in the last 10 years (from 2011 to 2020).
Mariana T. Donato; Rogério Colaço; Luís C. Branco; Benilde Saramago. A review on alternative lubricants: Ionic liquids as additives and deep eutectic solvents. Journal of Molecular Liquids 2021, 333, 116004 .
AMA StyleMariana T. Donato, Rogério Colaço, Luís C. Branco, Benilde Saramago. A review on alternative lubricants: Ionic liquids as additives and deep eutectic solvents. Journal of Molecular Liquids. 2021; 333 ():116004.
Chicago/Turabian StyleMariana T. Donato; Rogério Colaço; Luís C. Branco; Benilde Saramago. 2021. "A review on alternative lubricants: Ionic liquids as additives and deep eutectic solvents." Journal of Molecular Liquids 333, no. : 116004.
The ever-increasing interest in keeping a young appearance and healthy skin has leveraged the skincare industry. This, coupled together with the increased concern regarding the safety of synthetic products, has boosted the demand for new and safer natural ingredients. Accordingly, the aim of this study was to evaluate the dermatological potential of the brown seaweed Carpomitra costata. The antioxidant, anti-enzymatic, antimicrobial, photoprotective and anti-inflammatory properties of five C. costata fractions (F1–F5) were evaluated. The ethyl acetate fraction (F3) demonstrated the most promising results, with the best ability to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals (EC50 of 140.1 µg/mL) and the capacity to reduce reactive oxygen species (ROS) production promoted by UVA and UVB radiation in 3T3 cells, revealing its antioxidant and photoprotective potential. This fraction also exhibited the highest anti-enzymatic capacity, inhibiting the activities of collagenase, elastase and tyrosinase (IC50 of 7.2, 4.8 and 85.9 µg/mL, respectively). Moreover, F3 showed anti-inflammatory potential, reducing TNF-α and IL-6 release induced by LPS treatment in RAW 264.7 cells. These bioactivities may be related to the presence of phenolic compounds, such as phlorotannins, as demonstrated by NMR analysis. The results highlight the potential of C. costata as a source of bioactive ingredients for further dermatological applications.
Patrícia Susano; Joana Silva; Celso Alves; Alice Martins; Helena Gaspar; Susete Pinteus; Teresa Mouga; Márcia Goettert; Željko Petrovski; Luís Branco; Rui Pedrosa. Unravelling the Dermatological Potential of the Brown Seaweed Carpomitra costata. Marine Drugs 2021, 19, 135 .
AMA StylePatrícia Susano, Joana Silva, Celso Alves, Alice Martins, Helena Gaspar, Susete Pinteus, Teresa Mouga, Márcia Goettert, Željko Petrovski, Luís Branco, Rui Pedrosa. Unravelling the Dermatological Potential of the Brown Seaweed Carpomitra costata. Marine Drugs. 2021; 19 (3):135.
Chicago/Turabian StylePatrícia Susano; Joana Silva; Celso Alves; Alice Martins; Helena Gaspar; Susete Pinteus; Teresa Mouga; Márcia Goettert; Željko Petrovski; Luís Branco; Rui Pedrosa. 2021. "Unravelling the Dermatological Potential of the Brown Seaweed Carpomitra costata." Marine Drugs 19, no. 3: 135.
Mesoporous silica nanoparticles (MSNs) are very promising nanomaterials for treating bacterial infections when combined with pharmaceutical drugs. Herein, we report the preparation of two nanomaterials based on the immobilization of ciprofloxacin in mesoporous silica nanoparticles, either as the counter-ion of the choline derivative cation (MSN-[Ch][Cip]) or via anchoring on the surface of amino-group modified MSNs via an amide bond (MSN-Cip). Both nanomaterials were characterized by TEM, FTIR and solution 1H NMR spectroscopies, elemental analysis, XRD and N2 adsorption at 77 K in order to provide the desired structures. No cytotoxicity from the prepared mesoporous nanoparticles on 3T3 murine fibroblasts was observed. The antimicrobial activity of the nanomaterials was determined against Gram-positive (Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Klebsiella pneumoniae) bacteria and the results were promising against S. aureus. In the case of B. subtilis, both nanomaterials exhibited higher antimicrobial activity than the precursor [Ch][Cip], and in the case of K. pneumoniae they exhibited higher activity than neutral ciprofloxacin.
Blanca De Juan Mora; Luís Filipe; Andreia Forte; Miguel Santos; Celso Alves; Fernando Teodoro; Rui Pedrosa; Manuela Ribeiro Carrott; Luís Branco; Sandra Gago. Boosting Antimicrobial Activity of Ciprofloxacin by Functionalization of Mesoporous Silica Nanoparticles. Pharmaceutics 2021, 13, 218 .
AMA StyleBlanca De Juan Mora, Luís Filipe, Andreia Forte, Miguel Santos, Celso Alves, Fernando Teodoro, Rui Pedrosa, Manuela Ribeiro Carrott, Luís Branco, Sandra Gago. Boosting Antimicrobial Activity of Ciprofloxacin by Functionalization of Mesoporous Silica Nanoparticles. Pharmaceutics. 2021; 13 (2):218.
Chicago/Turabian StyleBlanca De Juan Mora; Luís Filipe; Andreia Forte; Miguel Santos; Celso Alves; Fernando Teodoro; Rui Pedrosa; Manuela Ribeiro Carrott; Luís Branco; Sandra Gago. 2021. "Boosting Antimicrobial Activity of Ciprofloxacin by Functionalization of Mesoporous Silica Nanoparticles." Pharmaceutics 13, no. 2: 218.
Background Intense and continuous physical training in sports is related with psychological and physiological stress, affecting the health and well-being of athletes. The development of non-invasive sampling methodologies is essential to consider sweat as a potential biological fluid for stress biomarker assessment. In the current work, the identification in sweat samples of potential molecules that may be used as stress biomarkers was pursued. Methods A sweat pool sample from football players after a 90-min intense training game was studied. Results An analysis method using liquid chromatography with detection by tandem mass spectrometry (LC-MSMS) to attain a screening profile of sweat composition is presented. The major focus was on neurotransmitters (e.g. monoamines and metabolites) and other biological molecules related with physical training, such as precursors of biogenic amines (phenylaniline, tyrosine, etc.). Conclusions This study allowed the identification of small biomolecules, neurotransmitters and other related molecules in sweat that are potentially associated with stress conditions. The developed methodology intends to contribute to the assessment and study of physical and psychological stress biomarkers related with intense sports using non-invasive methods.
Maria João Nunes; Cristina M. Cordas; José J. G. Moura; João Paulo Noronha; Luís Cobra Branco. Screening of Potential Stress Biomarkers in Sweat Associated with Sports Training. Sports Medicine - Open 2021, 7, 1 -9.
AMA StyleMaria João Nunes, Cristina M. Cordas, José J. G. Moura, João Paulo Noronha, Luís Cobra Branco. Screening of Potential Stress Biomarkers in Sweat Associated with Sports Training. Sports Medicine - Open. 2021; 7 (1):1-9.
Chicago/Turabian StyleMaria João Nunes; Cristina M. Cordas; José J. G. Moura; João Paulo Noronha; Luís Cobra Branco. 2021. "Screening of Potential Stress Biomarkers in Sweat Associated with Sports Training." Sports Medicine - Open 7, no. 1: 1-9.
Ionic oxidoperoxido-molybdenum(VI) complexes of the type [Cat][MoO(O2)2(pic)], with pic = N,O-chelated picolinate ligand and Cat = monocation, were prepared in high yields (82–95%) from the precursor complex [H3O][MoO(O2)2(pic)] via [H]+ cation exchange for 1-ethyl-3-methylimidazolium [EMIM]+, 1-butyl-3-methylimidazolium [BMIM]+, 1-octyl-3-methylimidazolium [OMIM]+, N-cetylpyridinium [C16Py]+, and N-methyl-N,N,N-trioctylammonium [Aliquat]+. The structure and purity of the ionic compounds were assessed by 1H and 13C NMR, FT-IR, and elemental analysis (C, H, N), and the electrochemical properties were studied by differential pulse voltammetry (DPV) and cyclic voltammetry (CV). The [Cat][MoO(O2)2(pic)] compounds showed promising catalytic epoxidation activity based on the model reaction of cis-cyclooctene with tert-butyl hydroperoxide as oxidant. The type of cation influenced the physical state of the compound and the catalytic performance.
Željko Petrovski; Margarida M. Antunes; Ana Soraia Mendo; Luís Cabrita; Isabel S. Gonçalves; Anabela A. Valente; Luís C. Branco. Ionic Liquids Based on Oxidoperoxido-Molybdenum(VI) Complexes with a Chelating Picolinate Ligand for Catalytic Epoxidation. Reactions 2020, 1, 147 -161.
AMA StyleŽeljko Petrovski, Margarida M. Antunes, Ana Soraia Mendo, Luís Cabrita, Isabel S. Gonçalves, Anabela A. Valente, Luís C. Branco. Ionic Liquids Based on Oxidoperoxido-Molybdenum(VI) Complexes with a Chelating Picolinate Ligand for Catalytic Epoxidation. Reactions. 2020; 1 (2):147-161.
Chicago/Turabian StyleŽeljko Petrovski; Margarida M. Antunes; Ana Soraia Mendo; Luís Cabrita; Isabel S. Gonçalves; Anabela A. Valente; Luís C. Branco. 2020. "Ionic Liquids Based on Oxidoperoxido-Molybdenum(VI) Complexes with a Chelating Picolinate Ligand for Catalytic Epoxidation." Reactions 1, no. 2: 147-161.
The majority of antibiotics display low oral bioavailability due to reduced solubility in water and/or inefficient permeability across biological membranes. Their efficiency is further limited by the frequent presence of polymorphic structures with different pharmaceutical activities. In this communication, we present our latest results on the development of organic salts and ionic liquids from fluoroquinolones (FQ-OSILs) as highly efficient ionic formulations of this family of antimicrobials. Ciprofloxacin and norfloxacin were used as anions and as cations, by combination with biocompatible organic counter-ions. In vitro bioavailability studies showed that all prepared FQ-OSILs presented higher solubility in water than the original drugs. All compounds were found to be isomorphic and with tailorable antimicrobial activity according to the cation–anion combination against Staphylococcus aureus, Bacillus subtilis and Klebsiella pneumoniae strains.
Diogo Madeira; Celso Alves; Joana Silva; Catarina Florindo; Alexandra Costa; Željko Petrovski; Isabel Marrucho; Rui Pedrosa; Miguel Santos; Luís Branco. Fluoroquinolone-Based Organic Salts and Ionic Liquids as Highly Bioavailable Broad-Spectrum Antimicrobials. Proceedings 2020, 78, 3 .
AMA StyleDiogo Madeira, Celso Alves, Joana Silva, Catarina Florindo, Alexandra Costa, Željko Petrovski, Isabel Marrucho, Rui Pedrosa, Miguel Santos, Luís Branco. Fluoroquinolone-Based Organic Salts and Ionic Liquids as Highly Bioavailable Broad-Spectrum Antimicrobials. Proceedings. 2020; 78 (1):3.
Chicago/Turabian StyleDiogo Madeira; Celso Alves; Joana Silva; Catarina Florindo; Alexandra Costa; Željko Petrovski; Isabel Marrucho; Rui Pedrosa; Miguel Santos; Luís Branco. 2020. "Fluoroquinolone-Based Organic Salts and Ionic Liquids as Highly Bioavailable Broad-Spectrum Antimicrobials." Proceedings 78, no. 1: 3.
Quaternary ammonium salts bearing different alkyl chains and hydroxyl groups were synthesized and tested for the first time as co-catalysts in the cycloaddition reaction between CO2 and propylene oxide. Their synergetic catalytic effect together with the known tetranuclear zinc(II) complex [Zn4(μ3-OH)2 (1κO:2κO-HL)4(κO-HL)2(H2O)4] (1), H2L = 3-(2-carboxyphenyl-hydrazone)pentane-2,4-dione, was investigated at 60 °C and 4 MPa. Results obtained highlight the importance of exploring the hydrogen bonding effect via functionalization with hydroxyl groups but show that the length of the alkyl chains of the ammonium cation is a more relevant factor affecting the reaction kinetic for the system studied.
Ana B. Paninho; Andreia Forte; Malgorzata E. Zakrzewska; Kamran T. Mahmudov; Armando J.L. Pombeiro; M. Fátima C. Guedes da Silva; Manuel Nunes da Ponte; Luís C. Branco; Ana V.M. Nunes. Catalytic effect of different hydroxyl-functionalised ionic liquids together with Zn(II) complex in the synthesis of cyclic carbonates from CO2. Molecular Catalysis 2020, 499, 111292 .
AMA StyleAna B. Paninho, Andreia Forte, Malgorzata E. Zakrzewska, Kamran T. Mahmudov, Armando J.L. Pombeiro, M. Fátima C. Guedes da Silva, Manuel Nunes da Ponte, Luís C. Branco, Ana V.M. Nunes. Catalytic effect of different hydroxyl-functionalised ionic liquids together with Zn(II) complex in the synthesis of cyclic carbonates from CO2. Molecular Catalysis. 2020; 499 ():111292.
Chicago/Turabian StyleAna B. Paninho; Andreia Forte; Malgorzata E. Zakrzewska; Kamran T. Mahmudov; Armando J.L. Pombeiro; M. Fátima C. Guedes da Silva; Manuel Nunes da Ponte; Luís C. Branco; Ana V.M. Nunes. 2020. "Catalytic effect of different hydroxyl-functionalised ionic liquids together with Zn(II) complex in the synthesis of cyclic carbonates from CO2." Molecular Catalysis 499, no. : 111292.
Since their discovery, deep eutectic solvents (DES) have been explored in multiple applications. However, the complete physicochemical characterization is still nonexistent for many of the proposed and used DES. In particular, vapor pressure, which is a crucial property for the application of DES as solvents, is very rarely available. In this work, the measurement of the total and partial pressures of two sulfolane-based DES, tetrabutylammonium bromide:sulfolane and tetrabutylphosphonium bromide:sulfolane, in several proportions, from 40 to 100 °C and atmospheric pressure, was performed using headspace gas chromatography mass spectrometry, HS-GC-MS. A large decrease on the total pressure was recorded which, together with the finding that total pressures showed negative deviations from Raoult's law, is indicative of the favorable, strong interactions between the two components within the DES. Additionally, the study of vapor pressure change with DES molar composition was carried out, and surprisingly, the existence of inflection points in the pressure curve was observed. Experimental results were modeled using the PC-SAFT equation of state, and in addition, MD simulations were performed to provide a molecular understanding of the pressure data. Considering the different results and insights obtained from the used strategies, it can be concluded that both DES systems have especially strong interactions between salt and sulfolane, at high sulfolane content, due to the different structural rearrangement of the liquid state.
Filipa Lima; Carin H. J. T. Dietz; Armando J. D. Silvestre; Luis C. Branco; José Canongia Lopes; Fausto Gallucci; Karina Shimizu; Christoph Held; Isabel M. Marrucho. Vapor Pressure Assessment of Sulfolane-Based Eutectic Solvents: Experimental, PC-SAFT, and Molecular Dynamics. The Journal of Physical Chemistry B 2020, 124, 10386 -10397.
AMA StyleFilipa Lima, Carin H. J. T. Dietz, Armando J. D. Silvestre, Luis C. Branco, José Canongia Lopes, Fausto Gallucci, Karina Shimizu, Christoph Held, Isabel M. Marrucho. Vapor Pressure Assessment of Sulfolane-Based Eutectic Solvents: Experimental, PC-SAFT, and Molecular Dynamics. The Journal of Physical Chemistry B. 2020; 124 (46):10386-10397.
Chicago/Turabian StyleFilipa Lima; Carin H. J. T. Dietz; Armando J. D. Silvestre; Luis C. Branco; José Canongia Lopes; Fausto Gallucci; Karina Shimizu; Christoph Held; Isabel M. Marrucho. 2020. "Vapor Pressure Assessment of Sulfolane-Based Eutectic Solvents: Experimental, PC-SAFT, and Molecular Dynamics." The Journal of Physical Chemistry B 124, no. 46: 10386-10397.
We report on the application of novel small-molecule highly crystalline pentacyclic diamides possessing significant OTFT and OLED potential.
Carolina S. Marques; Hugo Cruz; Simon E. Lawrence; Sandra Gago; João P. Prates Ramalho; Jorge Morgado; Luís C. Branco; Anthony J. Burke. Ambipolar pentacyclic diamides with interesting electrochemical and optoelectronic properties. Chemical Communications 2020, 56, 14893 -14896.
AMA StyleCarolina S. Marques, Hugo Cruz, Simon E. Lawrence, Sandra Gago, João P. Prates Ramalho, Jorge Morgado, Luís C. Branco, Anthony J. Burke. Ambipolar pentacyclic diamides with interesting electrochemical and optoelectronic properties. Chemical Communications. 2020; 56 (94):14893-14896.
Chicago/Turabian StyleCarolina S. Marques; Hugo Cruz; Simon E. Lawrence; Sandra Gago; João P. Prates Ramalho; Jorge Morgado; Luís C. Branco; Anthony J. Burke. 2020. "Ambipolar pentacyclic diamides with interesting electrochemical and optoelectronic properties." Chemical Communications 56, no. 94: 14893-14896.
Tuberculosis is one of the ten causes of morbidity and mortality worldwide caused by Mycobacterium tuberculosis complex. Some of the anti-tuberculosis drugs used in clinic studies, despite being effective for the treatment of tuberculosis, present serious adverse effects as well as poor bioavailability, stability, and drug-resistance problems. Thus, it is important to develop approaches that could provide shorter drug regimens, preventing drug resistance, toxicity of the antibiotics, and improve their bioavailability. Herein, we reported the use of organic salts based on the isoniazid drug, which can act as an organic cation combined with suitable organic anions such as alkylsulfonate-based (mesylate, R or S-Camphorsulfonate), carboxylate-based (glycolate, vanylate) and sacharinate. The synthesis, characterization, and cytotoxicity studies comparing with the original isoniazid drug have been performed. The possibility to explore dicationic salts seems promising in order to improve original bioavailability, and promote the elimination of polymorphic forms as well as higher stability, which are relevant characteristics that the pharmaceutical industry pursues.
Filipa Santos; Luís C. Branco; Ana Rita C. Duarte. Organic Salts Based on Isoniazid Drug: Synthesis, Bioavailability and Cytotoxicity Studies. Pharmaceutics 2020, 12, 952 .
AMA StyleFilipa Santos, Luís C. Branco, Ana Rita C. Duarte. Organic Salts Based on Isoniazid Drug: Synthesis, Bioavailability and Cytotoxicity Studies. Pharmaceutics. 2020; 12 (10):952.
Chicago/Turabian StyleFilipa Santos; Luís C. Branco; Ana Rita C. Duarte. 2020. "Organic Salts Based on Isoniazid Drug: Synthesis, Bioavailability and Cytotoxicity Studies." Pharmaceutics 12, no. 10: 952.
Over the last few decades, Ionic Liquids (ILs) and Deep Eutectic Solvents (DES) have been studied academically throughout many fields of chemical and biological research, including pharmaceutical sciences, due to their highly tunable physical, chemical and physicochemical properties
Miguel M. Santos; Luís C. Branco. Ionic Liquids and Deep Eutectic Solvents for Application in Pharmaceutics. Pharmaceutics 2020, 12, 909 .
AMA StyleMiguel M. Santos, Luís C. Branco. Ionic Liquids and Deep Eutectic Solvents for Application in Pharmaceutics. Pharmaceutics. 2020; 12 (10):909.
Chicago/Turabian StyleMiguel M. Santos; Luís C. Branco. 2020. "Ionic Liquids and Deep Eutectic Solvents for Application in Pharmaceutics." Pharmaceutics 12, no. 10: 909.
As the development of novel antibiotics has been at a halt for several decades, chemically enhancing existing drugs is a very promising approach to drug development. Herein, we report the preparation of twelve organic salts and ionic liquids (OSILs) from ciprofloxacin and norfloxacin as anions with enhanced antimicrobial activity. Each one of the fluoroquinolones (FQs) was combined with six different organic hydroxide cations in 93–100% yield through a buffer-assisted neutralization methodology. Six of those were isomorphous salts while the remaining six were ionic liquids, with four of them being room temperature ionic liquids. The prepared compounds were not toxic to healthy cell lines and displayed between 47- and 1416-fold more solubility in water at 25 and 37 °C than the original drugs, with the exception of the ones containing the cetylpyridinium cation. In general, the antimicrobial activity against Klebsiella pneumoniae was particularly enhanced for the ciprofloxacin-based OSILs, with up to ca. 20-fold decreases of the inhibitory concentrations in relation to the parent drug, while activity against Staphylococcus aureus and the commensal Bacillus subtilis strain was often reduced. Depending on the cation–drug combination, broad-spectrum or strain-specific antibiotic salts were achieved, potentially leading to the future development of highly bioavailable and safe antimicrobial ionic formulations.
Miguel Santos; Celso Alves; Joana Silva; Catarina Florindo; Alexandra Costa; Željko Petrovski; Isabel Marrucho; Rui Pedrosa; Luís Branco. Antimicrobial Activities of Highly Bioavailable Organic Salts and Ionic Liquids from Fluoroquinolones. Pharmaceutics 2020, 12, 694 .
AMA StyleMiguel Santos, Celso Alves, Joana Silva, Catarina Florindo, Alexandra Costa, Željko Petrovski, Isabel Marrucho, Rui Pedrosa, Luís Branco. Antimicrobial Activities of Highly Bioavailable Organic Salts and Ionic Liquids from Fluoroquinolones. Pharmaceutics. 2020; 12 (8):694.
Chicago/Turabian StyleMiguel Santos; Celso Alves; Joana Silva; Catarina Florindo; Alexandra Costa; Željko Petrovski; Isabel Marrucho; Rui Pedrosa; Luís Branco. 2020. "Antimicrobial Activities of Highly Bioavailable Organic Salts and Ionic Liquids from Fluoroquinolones." Pharmaceutics 12, no. 8: 694.
Skin aging is a biological process influenced by intrinsic and extrinsic factors. The last ones, mainly exposure to UV radiation, increases reactive oxygen species (ROS) production leading to a loss of extracellular matrix, also enhanced by enzymatic degradation of matrix supporting molecules. Thus, and with the growing demand for eco-friendly skin products, natural compounds extracted from brown seaweeds revealed to be good candidates due to their broad range of bioactivities, especially as antioxidants. The aim of this study was to assess the dermo-cosmetic potential of different fractions obtained from the brown seaweed Fucus spiralis. For this purpose, in vitro antioxidant (Total Phenolic Content (TPC), 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, Ferric Reducing Antioxidant Power (FRAP), Oxygen Radical Absorbance Capacity (ORAC)), anti-enzymatic (collagenase, elastase and hyaluronidase), antimicrobial, anti-inflammatory (NO production) and photoprotective (ROS production) capacities were evaluated. Although nearly all fractions evidenced antioxidant effects, fraction F10 demonstrated the highest antioxidant ability (EC50 of 38.5 µg/mL, DPPH assay), and exhibited a strong effect as an inhibitor of collagenase (0.037 µg/mL) and elastase (3.0 µg/mL). Moreover, this fraction was also the most potent on reducing ROS production promoted by H2O2 (IC50 of 41.3 µg/mL) and by UVB (IC50 of 31.3 µg/mL). These bioactivities can be attributed to its high content of phlorotannins, as evaluated by LC-MS analysis, reinforcing the potential of F. spiralis for further dermatological applications.
Rafaela Freitas; Alice Martins; Joana Silva; Celso Alves; Susete Pinteus; Joana Alves; Fernando Teodoro; Helena Ribeiro; Lídia Gonçalves; Željko Petrovski; Luís Branco; Rui Pedrosa. Highlighting the Biological Potential of the Brown Seaweed Fucus spiralis for Skin Applications. Antioxidants 2020, 9, 611 .
AMA StyleRafaela Freitas, Alice Martins, Joana Silva, Celso Alves, Susete Pinteus, Joana Alves, Fernando Teodoro, Helena Ribeiro, Lídia Gonçalves, Željko Petrovski, Luís Branco, Rui Pedrosa. Highlighting the Biological Potential of the Brown Seaweed Fucus spiralis for Skin Applications. Antioxidants. 2020; 9 (7):611.
Chicago/Turabian StyleRafaela Freitas; Alice Martins; Joana Silva; Celso Alves; Susete Pinteus; Joana Alves; Fernando Teodoro; Helena Ribeiro; Lídia Gonçalves; Željko Petrovski; Luís Branco; Rui Pedrosa. 2020. "Highlighting the Biological Potential of the Brown Seaweed Fucus spiralis for Skin Applications." Antioxidants 9, no. 7: 611.
Deep eutectic solvents (DES) composed of lithium, sodium, or potassium iodide salts in suitable combination with ethylene glycol (EG), glycerol (Gly), or polyethylene glycol (PEG) have been developed. All prepared DES were characterized by thermal analysis (DSC and TGA) and its complex conductivity (σ*) and impedance (Z*) frequency were evaluated through dielectric relaxation spectroscopy (DRS). Two- and three-electrode electrochemical studies of all DES have been performed. All DES avoid crystallization, exhibiting conductivity values in a range from 10–4 to 10–2 S cm–1 at room temperature and electrochemical windows higher than 1 V (on the order of 3–4 V), fulfilling the usual suitability criteria for utilization in electrochromic devices (ECD). The most promissory DES as electrolytes were tested for ECD. Being suitable candidates for further application in batteries.
Hugo Cruz; Noemi Jordao; Ana Lucia Pinto; Madalena Dionisio; Luisa A. Neves; Luis C. Branco. Alkaline Iodide-Based Deep Eutectic Solvents for Electrochemical Applications. ACS Sustainable Chemistry & Engineering 2020, 1 .
AMA StyleHugo Cruz, Noemi Jordao, Ana Lucia Pinto, Madalena Dionisio, Luisa A. Neves, Luis C. Branco. Alkaline Iodide-Based Deep Eutectic Solvents for Electrochemical Applications. ACS Sustainable Chemistry & Engineering. 2020; ():1.
Chicago/Turabian StyleHugo Cruz; Noemi Jordao; Ana Lucia Pinto; Madalena Dionisio; Luisa A. Neves; Luis C. Branco. 2020. "Alkaline Iodide-Based Deep Eutectic Solvents for Electrochemical Applications." ACS Sustainable Chemistry & Engineering , no. : 1.
Anthocyanins recycling and transformations into novel compounds have been of great interest of the scientific community to improve the circular economy and enhance their technological applications. The enzymatic acylation of anthocyanins into lipophilic derivatives by conjugation with fatty acids emerged as one of the approaches; however, the literature describes only the use of organic solvents and conventional heating. In this work, the production of cyanidin-3-glucoside-octanoic acid conjugate combining ionic liquids (ILs), microwave (MW) irradiation, and Candida antarctica lipase B as a biocatalyst was attempted for the first time. Overall, the use of MW irradiation could reduce drastically the reaction time, allowing the formation of an acylated product with similar concentrations to the conventional method. On the other hand, the study of the lipophilic conjugate synthesis using different ILs showed that their composition is crucial to achieve the desired enzymatic reaction, and in this case, the combination of an imidazolium derivative as the cation with the triflate as the anion was suitable for the production of this derivative. These promising results achieved through the combination of greener alternatives to those reported in the literature are a starting point for further developments to produce this kind of anthocyanin derivatives exploring such sustainable and ecofriendly conditions.
Marta Guimarães; Nuno Mateus; Victor De Freitas; Luis C. Branco; Luis Miguel Cruz. Microwave-Assisted Synthesis and Ionic Liquids: Green and Sustainable Alternatives toward Enzymatic Lipophilization of Anthocyanin Monoglucosides. Journal of Agricultural and Food Chemistry 2020, 68, 1 .
AMA StyleMarta Guimarães, Nuno Mateus, Victor De Freitas, Luis C. Branco, Luis Miguel Cruz. Microwave-Assisted Synthesis and Ionic Liquids: Green and Sustainable Alternatives toward Enzymatic Lipophilization of Anthocyanin Monoglucosides. Journal of Agricultural and Food Chemistry. 2020; 68 (28):1.
Chicago/Turabian StyleMarta Guimarães; Nuno Mateus; Victor De Freitas; Luis C. Branco; Luis Miguel Cruz. 2020. "Microwave-Assisted Synthesis and Ionic Liquids: Green and Sustainable Alternatives toward Enzymatic Lipophilization of Anthocyanin Monoglucosides." Journal of Agricultural and Food Chemistry 68, no. 28: 1.